1000 resultados para 1995_01240858 MOC-10
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Monthly newsletter for the Iowa Department of Public Health
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The Fiscal Division newsletter, published weekly during session and periodically during the interim.
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The Fiscal Division newsletter, published weekly during session and periodically during the interim.
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OBJECTIVES: Representative prevalence data of transmitted drug-resistant HIV-1 are essential to establish accurate guidelines addressing resistance testing and first-line treatments. METHODS: Systematic resistance testing was carried out in individuals in Switzerland with documented HIV-1 seroconversion during 1996-2005 and available samples with RNA > 1000 copies/ml obtained within 1 year of estimated seroconversion. Resistance interpretation used the Stanford list of mutations for surveillance of transmitted drug resistance and the French National Agency for AIDS Research algorithm. RESULTS: Viral sequences from 822 individuals were available. Risk groups were men having sex with men (42%), heterosexual contacts (32%) and intravenous drug users (20%); 30% were infected with non-B subtype viruses. Overall, prevalence of transmitted resistance was 7.7% [95% confidence interval (CI), 5.9-9.5] for any drug, 5.5% (95% CI, 3.9-7.1) for nucleoside reverse transcriptase inhibitors, 1.9% (95% CI, 1.0-2.8) for non-nucleoside reverse transcriptase inhibitors and 2.7% (95% CI, 1.6-3.8) for protease inhibitors. Dual- or triple-class resistance was observed in 2% (95% CI, 0.8-2.5). No significant trend in prevalence of transmitted resistance was observed over years. There were no differences according to ethnicity, risk groups or gender, but prevalence of transmitted resistance was highest among individuals infected with subtype B virus. CONCLUSIONS: The transmission rate of drug-resistant HIV-1 has been stable since 1996, with very rare transmission of dual- or triple-class resistance. These data suggest that transmission of drug resistance in the setting of easy access to antiretroviral treatment can remain stable and be kept at a low level.
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A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management
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A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management
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A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management
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A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management
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A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management
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Monthly newsletter of State Library
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Monthly newsletter for the Iowa Department of Public Health