Fibroblast Growth Factor 23 Is an Independent and Specific Predictor of Mortality in Patients With Heart Failure and Reduced Ejection Fraction

BACKGROUND Strategies to improve risk prediction are of major importance in patients with heart failure (HF). Fibroblast growth factor 23 (FGF-23) is an endocrine regulator of phosphate and vitamin D homeostasis associated with an increased cardiovascular risk. We aimed to assess the prognostic effect of FGF-23 on mortality in HF patients with a particular focus on differences between patients with HF with preserved ejection fraction and patients with HF with reduced ejection fraction (HFrEF). METHODS AND RESULTS FGF-23 levels were measured in 980 patients with HF enrolled in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study including 511 patients with HFrEF and 469 patients with HF with preserved ejection fraction and a median follow-up time of 8.6 years. FGF-23 was additionally measured in a second cohort comprising 320 patients with advanced HFrEF. FGF-23 was independently associated with mortality with an adjusted hazard ratio per 1-SD increase of 1.30 (95% confidence interval, 1.14-1.48; P<0.001) in patients with HFrEF, whereas no such association was found in patients with HF with preserved ejection fraction (for interaction, P=0.043). External validation confirmed the significant association with mortality with an adjusted hazard ratio per 1 SD of 1.23 (95% confidence interval, 1.02-1.60; P=0.027). FGF-23 demonstrated an increased discriminatory power for mortality in addition to N-terminal pro-B-type natriuretic peptide (C-statistic: 0.59 versus 0.63) and an improvement in net reclassification index (39.6%; P<0.001). CONCLUSIONS FGF-23 is independently associated with an increased risk of mortality in patients with HFrEF but not in those with HF with preserved ejection fraction, suggesting a different pathophysiologic role for both entities.

Selective sampling during catastrophic disruption: Mapping the location of reaccumulated fragments in the original parent body

In this paper, we simulate numerically the catastrophic disruption of a large asteroid as a result of a collision with a smaller projectile and the subsequent reaccumulation of fragments as a result of their mutual gravitational attractions. We then investigate the original location within the parent body of the small pieces that eventually reaccumulate to form the largest offspring of the disruption as a function of the internal structure of the parent body. We consider four cases that may represent the internal structure of such a body (whose diameter is fixed at 250 km) in various early stages of the Solar System evolution: fully molten, half molten (i.e., a 26 km-deep outer layer of melt containing half of the mass), solid except a thin molten layer (8 km thick) centered at 10 km depth, and fully solid. The solid material has properties of basalt. We then focus on the three largest offspring that have enough reaccumulated pieces to consider. Our results indicate that the particles that eventually reaccumulate to form the largest reaccumulated bodies retain a memory of their original locations in the parent body. Most particles in each reaccumulated body are clustered from the same original region, even if their reaccumulations take place far away. The extent of the original region varies considerably depending on the internal structure of the parent. It seems to shrink with the solidity of the body. The fraction of particles coming from a given depth is computed for the four cases, which can give constraints on the internal structure of parent bodies of some meteorites. As one example, we consider the ureilites, which in some petrogenetic models are inferred to have formed at particular depths within their parent body. (C) 2014 Elsevier Ltd. All rights reserved.

Eine Vogelschau über die Entwickelung der amerikanischen Judenheit in den letzten 250 Jahren

Isidor Singer

Eine Vogelschau über die Entwickelung der amerikanischen Judenheit in den letzten 250 Jahren

Isidor Singer

Continued Fraction Solutions to Hermite's, Legendre's and Laguerre's Differential Equation

The continued fraction method for solving differential equations is illustrated using three famous differential equations used in quantum chemistry.

Der Spinozismus in der Philosophie der Gegenwart : zum 250. Todestage Spinozas (21. Februar 1677)

Albert Lewkowitz

Nochmals: Klausners Jesus-Werk [Nachricht] : Erwiderung auf M. Guttmanns Besprechung ; Jg. 1931, S. 250 ff.

Josef Klausner

Bach und Händel : zu ihrem 250. Geburtstag

Oskar Guttmann

Spinoza : Anläßlich der 250. Wiederkehr seines Todestages

Wilhelm Löwinger

Na 1 Nachlass Max Horkheimer, 19 - Korrespondenzen u.a. mit Alfred Haas (p. I 10, 1-250)

20 Briefe zwischen Alfred Haas und Max Horkheimer, 1935-1941; 2 Briefe von Willy Haas an Max Horkheimer, 1938; 3 Briefe zwischen Virginia Haber und Max Horkheimer, 12.09.1945, August 1945; 7 Briefe zwischen Hugo Hahn und Max Horkheimer, 1942-1946; 1 Brief von Max Horkheimer an Charles G. Haines, 23.10.1940; 1 Brief von Max Horkheimer an Hall, 02.07.1939; 2 Briefe zwischen H. Duncan Hall und Max Horkheimer, 04.08.1939, 24.07.1939; 2 Briefe zwsichen Herbert Berkerath und Max Horkheimer, 10.10.1939, 09.10.1939; 23 Briefe zwischen Wolfgang Hallgarten und Max Horkheimer, 1937-1941; 1 Brief von Max Horkheimer an die American Philosophic Society Philadelphia, 15.04.1940; 2 Briefe zwischen Betty Drury und Max Horkheimer, 29.02.1940, 20.02.1940; 6 Briefe zwischen Nina Almond und Max Horkheimer, 1939; 1 Brief von Ruth E. Hollander an Max Horkheimer, 08.09.1938; 1 Brief von dem Brooklyn College an Wolfgang Hallgarten, 29.04.1938; 4 briefe zwischen dem Brooklyn College und Max Horkheimer, 18.05.1938, 17.05.1938; 2 Briefe zwischen Robert Maynard Hutchins und Max Horkheimer, 02.11.1937, 28.10.1937; 2 Briefe zwsichen Hardt und Max Horkheimer, 01.10.1943; 4 Briefe zwischen Gertrude Hardt und Max Horkheimer, 1947-1948; 4 Briefe zwischen den Harper & Brothers New York und Max Horkheimer, 24.10.1950, 1950; 1 Brief von Friedrich Pollock an Margot von Mendelssohn, 13.09.1950; 1 Brief von Hartoch an Max Horkheimer, 09.06.1937; 4 Briefe zwischen dem Harvard College Cambridge Massachusetts und Max Horkheimer, 1939-1940; 3 Briefe zwischen Felix Hase und Max Horkheimer, 1936, 13.03.1936; 1 Brief von Freda E. Hecht an Max Horkheimer, 01.03.1947; 1 Brief von Ernest S. Hediger an Max Horkheimer, 02.09.1940; 2 Briefe zwischen Agnes Heilbut und Max Horkheimer, 18.07.1938,; 7 Briefe zwischen Eduard Heimann und Max Horkheimer, 1936-1939; 1 Brief von Fritz Hein an Max Horkheimer, 14.06.1949; 2 Briefe zwischen Walter Heinemann und Max Horkheimer, 15.02.1945, 12.03.1945; 2 Briefe zwischen Philipp Heller und Max Horkheimer, 16.09.1944, 09.10.1944; 1 Brief von Max Horkheimer an Hellmann, 23.03.1939; 4 Briefe zwischen L. E. Hellmann und Max Horkheimer, 1939; 4 Briefe zwischen P. A. Hemerijk und Max Horkheimer, 1936-1937, 03.02.1936; 5 Briefe zwischen Carl G. Hempel und Max Horkheimer, 1939-1941; 1 Lebenslauf von Hans Henning; 1 Brief von Else Henschke an Max Horkheimer, 24.07.1940; 1 Briefe von Isi Hepner an Max Horkheimer, 23.01.1941; 1 Brief von Leo Löwenthal an Isi Hepner, 03.02.1941; 1 Brief von Gertrude E. Herman anMax Horkheimer, 10.12.1949; 1 Brief von Wilhelm G. Hertz an Max Horkheimer, 29.09.1938; 2 Briefe zwischen Wieland Herzfelde und der National City Bank of New York, 28.11.1939, 30.11.1939; 2 Briefe zwischen Karl Hess und Max Horkheimer, 14.08.1935, 25.10.1934; 4 Briefe zwischen Karl Heymann und Max Horkheimer, 1947, 1949; 19 Briefe zwischen Robert Hilb und Max Horkheimer, 1937-1941; 2 Briefe zwischen Joseph Rosenthal und Max Horkheimer, 12.11.1940, 25.10.1940; 2 Briefe zwischen Henry Church und Max Horkheimer, 14.12.1940, 18.12.1940; 1 Brief von Ellen Hilb an Max Horkheimer, 11.03.1938; 1 Brief von Emil Hilb an Max Horkheimer, 15.04.1939; 2 Briefe zwischen Yoshitaro Hirano und Max Horkheimer, 1936, 23.01.1936; 2 Briefe von Max Horkheimer an Hirsch, 1938; 1 Brief von Arnold Hirsch an Max Horkheimer, 14.07.1949; 4 Briefe zwischen Charles Hirsch und Max Horkheimer, 1937, 1938; 2 Briefe von Max Horkheimer an Ernst Hirsch, Oktober 1938; 1 Brief von Max Horkheimer an Julius Hirsch, 24.02.1942;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 250 - Antwortschreiben über die Verkaufsbedingungen der mexikanischen Anleihen

u.a.: Conversion of mexican Bonds;

Ms.Ff.F.Stoltze 3. 250 - Brief von Karl Theodor Reiffenstein an Friedrich Stoltze

Geburtstags-Glückwünsche (Gedicht), Rebstock

Ms. Ff. Mus. 250 - Fer. 2. Pasch. : INI [in nomine Jesu] ; 15

[Johann Christoph Graupner]

Ms. lat. oct. 250 - Konklaveberichte. Denkschriften. Satirische Gedichte

Die Foliierung geht nur bis Bl. 470; zusätzlich gibt es das Blatt 324a.