993 resultados para identificação bioquímica


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O film noir, embora seja reconhecido sem dificuldade na cultura cinéfila e até na cultura contemporânea de massas em geral, não pode ainda assim ser definido instantaneamente pelo seu ambiente ou pela presença de determinadas personagens. Por muito difícil que seja captar a essência do noir, tendo em conta apenas fatores estilísticos ou temáticos, é necessário focar a atenção em dados mais concretos e consistentes e tentar encontrar as singularidades que definam o film noir de forma mais objectiva e, ao mesmo tempo, matizada. Para desenvolver a investigação e a sua aplicação projetual associada ao cinema/ vídeo, foi este género cinematográfico e as suas influências, que foi o escolhido, por estar balizado num curto período temporal(de 1941 a 1958)mas com evidentes marcadores que subsistem para além deste período. O objetivo deste projeto é identificar e analisar os padrões e estereótipos do film noir, procurando seguir e interpretar a respectiva influência no universo da cultura visual atual. Para além de uma recolha preliminar de informação que permitiu elaborar uma definição concreta sobre o problema a estudar e as suas origens, analisou-se um número considerável de filmes referenciados como pertencentes ao modelo do film noir. O projeto de investigação culmina no vídeo “Film noir” que é uma recolha de sequências e imagens de diferentes filmes da era do film noir clássico, onde a junção destas cria uma história nova que se enquadra no estilo narrativo dos filmes noir. Por fim, o trabalho é ainda uma ode ainda uma ode e homenagem ao cinema noir.

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O estudo objetivou identificar fatores demográficos, econômicos e atitudinais discriminadores do comportamento de consumo dos universitários. Foi aplicado questionário a uma amostra não-probabilística de 253 universitários. A estimativa do tamanho dos segmentos de consumidores universitários menos ambientalmente favoráveis e mais ambientalmente favoráveis coincide em 50%. Foi utilizada a análise discriminante como técnica estatística multivariada, cujos resultados revelaram a relevância estatística de quatro das dez variáveis inicialmente selecionadas: comprometimento ambiental autodeclarado (atual e futuro), atitude em relação a reciclagem e idade, as quais conseguiram gerar uma capacidade preditiva de 72% para o modelo, considerada acima do aceitável.

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A reação dos mercados às alterações na taxa básica de juros é relevante para toda a economia. O entendimento da relação entre a política monetária e as taxas de juros é de extrema importância, uma vez que surpresas monetárias, ou seja, os erros de previsão do mercado a respeito das alterações da meta da Taxa Selic, podem afetar as taxas de juros de diferentes maturidades ou vencimentos, impactando diretamente a Administração Financeira. O objetivo deste estudo foi analisar a variação da Estrutura a Termo da Taxa de Juros (ETTJ) quando verificadas surpresas monetárias na ocasião da decisão do Comitê de Política Monetária (Copom) a respeito da meta da Taxa Selic. Para isso, foi desenvolvido um estudo descritivo quantitativo, que considerou as 88 reuniões ordinárias do Copom realizadas no período de janeiro de 2004 a dezembro de 2013. As surpresas monetárias foram identificadas através de duas formas distintas. Na primeira forma foram consideradas as taxas do contrato de DI1 referente ao último negócio realizado no pregão da data da reunião do Copom, e a taxa do primeiro negócio realizado no pregão seguinte. Desta maneira foram identificadas 11 surpresas monetárias. Na segunda forma foram consideradas as taxas médias verificadas nos mesmos contratos e ocasiões citados anteriormente, sendo assim identificadas 10 surpresas monetárias. Já para a análise da relação entre as variações da ETTJ e as surpresas monetárias foram considerados os vencimentos de 2, 3, 6, 9, 12, 15, 18 e 24 meses. Como resultado foi possível observar que as surpresas monetárias e as variações na ETTJ são diretamente proporcionais, movendo-se na mesma direção, para as duas formas distintas de surpresas monetárias identificadas neste estudo. Além disso, foi empregada nas análises a questão da unanimidade na decisão do Copom, com o objetivo testar o seu conteúdo informacional, e observou-se como resultado uma menor variação da ETTJ em ocasiões em que a decisão do Copom foi unânime. Em resumo, entende-se que os resultados encontrados no presente estudo estão em linha aos apresentados por outros autores, sendo possível comprovar a correlação existente entre as variações da ETTJ e as surpresas monetárias, bem como verificar que a magnitude das variações diminui ao longo da ETTJ, fato este que pode ser relacionado à transparência da política monetária nacional e à experiência na vigência do sistema de metas para a inflação.

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A pesquisa, em 5 capítulos, desenvolve o tema dos/as pobres como categoria social nos Sl 3-14, subunidade do primeiro livro do saltério (Sl 3-41). Os Sl 3-14 são atribuídos a Davi, o fato está relacionado com as escolas e suas teologias presentes na edição final do saltério. Esses salmos nasceram nas comunidades camponesas do antigo Israel, posteriormente, foram aperfeiçoados e adaptados por grupos de cantores oficiais no templo de Jerusalém. Os Sl 3-14 se destacam pelo lamento e pela súplica individual. Pertencem a uma coleção pré-exílica, mas concentra textos tardios, do pós-exílio. Os lugares que ocupam foram pensados estrategicamente. Os Sl 9; 10 apresentam conceitos hebraicos que identificam os/as pobres: dak, ani, ebyon. Estes/as designam pequenos/as camponeses/as livres, ainda com acesso à terra. Ao longo do antigo Israel não sofreram mudanças bruscas como categoria social, no entanto, podem assinalar-se algumas características que os/as distinguem nos períodos correspondentes ao primeiro e o segundo templo de Jerusalém. Ademais, os Sl 9; 10 apresentam palavras sinônimas que também os/as identificam: hellkah pobre/infeliz e naqi inocente . Apesar das pequenas variações dos conceitos, todos apontam à uma categoria social, com direito à apelação nos tribunais, embora com fraca influência jurídica. Essa comunidade tem identidade teológica. Javé é apresentado como o seu defensor. A espoliação no saltério é algo dramático, porque o rosto do/a pobre é o próprio rosto de Javé. A pobreza não é um assunto de espiritualidade nem de casualidade. É gerada por um sistema político-social, planejado de forma inteligente, que não permite ao povo da roça progredir como agricultor. Esse setor poderoso, nacional ou estrangeiro, é identificado nos textos, sob os conceitos: goyim nações , sorerim agressores , oyebim inimigos , raxa im injustos . O seu domínio é suportado pela violência e as armas. A ideologia dos sistemas dominantes é fundamental para a interpretação dos textos. A sociedade dos salmistas apresenta crises com relação à identidade humana. A violência e a paz se disputam os espaços. O Sl 8 mostra uma sociedade alternativa pensada a partir daquilo aparentemente fraco: as olelim crianças e os yanaqim lactantes (Sl 8,3). O grito das criancinhas, o grito dos/as oprimidos/as, unido ao grito da criação, se compara à dor de parto, com o qual inicia a vida. Trata-se de um grito que busca transformar os trajetos entortados da história. Esses são indícios da esperança que distingue a teologia dos/as pobres. Os Sl 3-7 e 11-14 continuam a apresentar a situação dos/as pobres. Às vezes, localizam-se os conceitos: ani oprimido e ebyon pobre , outras, recorre-se a novos sinônimos como has͇id fiel e sadiq justo . Esses salmos demonstram que os/as pobres estão presentes também nos textos onde tais conceitos não aparecem. As agrupações (Sl 3-7 e 11-14) são uma pausa na subunidade (Sl 3-14), não uma quebra de sentido com os Sl 8; 9 e 10. Finalmente, se localiza na sociedade dos Sl 3-14, o Modo de Produção Tributário. As teorias das ciências econômica, arqueológica, histórica, contribuem com a compreensão do universo sóciopolítico gerador de pobres.

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O presente trabalho teve como objetivos investigar a presença de manifestações psicossomáticas em estudantes universitários, a partir da identificação e da prevalência de sintomas de ansiedade, depressão e stress entre outros transtornos; identificar sinais e sintomas de ansiedade, depressão e stress em universitários portugueses; e correlacionar os sinais e sintomas entre si. Utilizou-se o método quantitativo descritivo de corte transversal. Como meio de investigação, foram utilizados três instrumentos: O Inventário de Ansiedade Traço-Estado de Spilberber IDATE, a Escala de Ansiedade, Depressão e Stress EADS-21 (DASS) e o Inventário de Sintomas de Stress para Adultos de Lipp ISSL. A amostra resultou em 147 universitários de primeiro ingresso na universidade com idade variando entre 18 e 26 anos da Universidade do Algarve Ualg (Portugal), em seus diversos cursos. Os dados obtidos foram analisados e correlacionados com o auxilio do software estatístico SPSS - Statistical Package for Social Science (SPSS), versão 19.0 para Windows, utilizando a análise estatística descritiva de frequência e média, Teste T de Student e ANOVA. Os resultados apontaram uma amostra em sua maioria de mulheres, solteiras, que saíram da casa dos pais para estudar e que no momento da coleta dos dados não exerciam atividades de trabalho, apenas estudavam. Houve presença de indicadores de ansiedade, depressão e stress, sendo o nível de ansiedade encontrado moderado e vinculado à probabilidade de depressão associada. Em relação a manifestações psicossomáticas, foi identificada uma dificuldade em auto-avaliação da presença destas, porém entendeu-se que há associação de manifestações psicossomáticas em relação aos sintomas de stress, ansiedade e depressão, encontrados. Levantou-se a hipótese de associação desses sintomas com a situação atual de crise econômica que passa a sociedade portuguesa, principalmente no período de coleta desses dados. Assim, verificou-se um possível estado de vulnerabilidade nesta população com alguma dificuldade em se adaptar às novas exigências de vida, necessitando então de medidas preventivas que auxiliem a adaptação e reestruturação do estilo de vida desses estudantes.

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Many species have specialized to live in the most varied existing environments showing the remarkable adaptability of the microbial world the most diverse physicochemical conditions. Environments exposed to natural radiation and metals are scarce around the world, presenting a microbiota still unknown. With a total number estimated between 4 and 6 x 1030 microrganisms on earth, they constitute an enormous biological and genetic pool to be explored. Metagenomic approach independent of cultivation, provides a new form to access to the potential genomic environmental samples becoming a powerful tool for the elucidation of ecological functions, metabolic profiles, as well as to identify new biomolecules. In this context, the genetic material of environmental soil and water samples from Açude Boqueirao Parelhas-RN, under the influence of natural radiation and the presence of metals, was extracted, pirosequencing and the generated sequences were analyzed by bioinformatics programs (MG-RAST and STAMP). Taxonomic comparative profiles of both samples showed high abundance of Domain Bacteria, followed by a small portion attributable to Eucaryota Domains, Archaea and Viruses. Proteobacteria, Actinobacteria and Bacterioidetes phyla showed the greater dominance in both samples. Important genera and species associated with resistance to various stressors found in region were observed. Sequences related to oxidative and heat stress, DNA replication and repair, and resistance to toxic compounds were observed, suggesting a significant relationship between the microbiota and their metabolic profile, influenced by regional environmental variables. The results of this study add valuable and unpublished data on the composition of microbial communities in these regions

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The microorganisms have a vast genetic diversity and they are present throughout the biosphere, however, only about 1% of the species can be cultivated by traditional cultivation techniques. Within this diversity there is a huge pool genetic and biological being explored. The metagenomics has enabled direct access to microbial genome derived from environmental samples using independent methods of cultivation. The methodology enables to obtain functional information about the proteins, as well as identify potential products with biotechnological interest and new industrially exploitable biological resources, such as new solutions to environmental impacts. Oil-contaminated areas are characterized by a large accumulation of hydrocarbons and surfactants may be used for bioremediation. Thus, the metagenomic approach was used in this study in order to select genes involved in the degradation and hydrocarbon emulsification. In a previous work, the environmental DNA (eDNA) was extracted from soil samples collected from two different areas (Caatinga and Saline River) of Rio Grande do Norte (Brazil), the metagenomic libraries were constructed and functionally analyzed. The clone able to degrade the oil was evaluated for the ability to synthesize biosurfactants. The sequence analysis revealed an ORF with 897 bp, 298 amino acids and a protein with around 34 kDa. The search for homology in GenBank revealed sequence similarity with a hypothetical protein of representatives Halobacteriaceae family, who were recently shown as strains producing biosurfactants. The presence of the inserted coding sequence and the acquired phenotype was confirmed. Primers were designed and the ORF amplified by PCR. The ORF was subcloned into pETDuet-1 expression vector for subsequent purification of the protein of interest containing a histidine tail. The tests performed to confirm the biosurfactant activity and the ability of hydrocarbon degradation showed positive results. The immunodetection test (western blot) using the monoclonal AntiHis® confirmed the presence of the environmental protein. This study was the first to report a possible protein with biosurfactant activity obtained from a metagenomic approach

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Energy is a vital resource for social and economic development. In the present scenario, the search for alternative energy sources has become fundamental, especially after the oil crises between 1973 and 1979, the Chernobyl nuclear accident in 1986 and the Kyoto Protocol in 1997. The demand for the development of new alternative energy sources aims to complement existing forms allows to meet the demand for energy consumption with greater security. Brazil, with the guideline of not dirtying the energy matrix by the fossil fuels exploitation and the recent energy crisis caused by the lack of rains, directs energy policies for the development of other renewable energy sources, complementing the hydric. This country is one of the countries that stand out for power generation capacity from the winds in several areas, especially Rio Grande do Norte (RN), which is one of the states with highest installed power and great potential to be explored. In this context arises the purpose of this work to identify the incentive to develop policies of wind energy in Rio Grande do Norte. The study was conducted by a qualitative methodology of data analysis called content analysis, oriented for towards message characteristics, its informational value, the words, arguments and ideas expressed in it, constituting a thematic analysis. To collect the data interviews were conducted with managers of major organizations related to wind energy in Brazil and in the state of Rio Grande do Norte. The identification of incentive policies was achieved in three stages: the first seeking incentives policies in national terms, which are applied to all states, the second with the questionnaire application and the third to research and data collection for the development of the installed power of the RN as compared to other states. At the end, the results demonstrated hat in Rio Grande do Norte state there is no incentive policy for the development of wind power set and consolidated, specific actions in order to optimize the bureaucratic issues related to wind farms, especially on environmental issues. The absence of this policy hinders the development of wind energy RN, considering result in reduced competitiveness and performance in recent energy auctions. Among the perceived obstacles include the lack of hand labor sufficient to achieve the reporting and analysis of environmental licenses, the lack of updating the wind Atlas of the state, a shortfall of tax incentives. Added to these difficulties excel barriers in infrastructure and logistics, with the lack of a suitable port for large loads and the need for reform, maintenance and duplication of roads and highways that are still loss-making. It is suggested as future work the relationship of the technology park of energy and the development of wind power in the state, the influence of the technology park to attract businesses and industries in the wind sector to settle in RN and a comparison of incentive policies to development of wind energy in the Brazilian states observing wind development in the same states under study.

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In the central nervous system (CNS) of mammalian, fast synaptic transmission between nerve cells is performed primarily by α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA) receptors, an ionotropic glutamate receptor that is related with learning, memory and homeostasis of the nervous system. Impairments in their functions are correlated with development of many brain desorders, such as epilepsy, schizophrenia, autism, Parkinson and Alzheimer. The use of willardiine analogs has been shown a powerful tool to understanding of activation and desensitization mechanisms of this receptors, because the modification of a single ligand atom allows the observation of varying levels of efficacy. In this work, taking advantage of Fluorine Willardiine (1.35Å), Hydrogen Willardiine (1.65Å), Bromine Willardiine (1.8Å) and Iodine Willardiine (2.15Å) structures co-crystalized with GluA2 with codes 1MQI, 1MQJ, 1MQH and 1MQG, we attempted to energetically differentiate the four ligands efficacy. The complexes were submitted to energetic calculations based on density functional theory (DFT), under the optics of molecular fractionation with conjugate caps (MFCC) method. Obtained results show a relationship between the energetic values and willardiines efficacy order (FW> HW > BrW > IW), also show the importance of E705, R485, Y450, S654, T655, T480 e P478 as the amino acids that contribute most strongly with the interaction of four partial agonists. Furthermore, we outlined the M708 behaviour, attracted by FW and HW ligands, and repels by BrW and IW. With the datas reported on this work, it is possible for a better understanding of the AMPA receptor, which can serve as an aid in the development of new drugs for this system.

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There are authentication models which use passwords, keys, personal identifiers (cards, tags etc) to authenticate a particular user in the authentication/identification process. However, there are other systems that can use biometric data, such as signature, fingerprint, voice, etc., to authenticate an individual in a system. In another hand, the storage of biometric can bring some risks such as consistency and protection problems for these data. According to this problem, it is necessary to protect these biometric databases to ensure the integrity and reliability of the system. In this case, there are models for security/authentication biometric identification, for example, models and Fuzzy Vault and Fuzzy Commitment systems. Currently, these models are mostly used in the cases for protection of biometric data, but they have fragile elements in the protection process. Therefore, increasing the level of security of these methods through changes in the structure, or even by inserting new layers of protection is one of the goals of this thesis. In other words, this work proposes the simultaneous use of encryption (Encryption Algorithm Papilio) with protection models templates (Fuzzy Vault and Fuzzy Commitment) in identification systems based on biometric. The objective of this work is to improve two aspects in Biometric systems: safety and accuracy. Furthermore, it is necessary to maintain a reasonable level of efficiency of this data through the use of more elaborate classification structures, known as committees. Therefore, we intend to propose a model of a safer biometric identification systems for identification.

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World consumption of vegetable oils has increased in recent years because of its application in food, chemical, pharmaceutical and, more recently, energy industry. However, oilseeds, which these oils are extracted, have low viability, affecting the cultivation and productivity of these species. The aim of this study was to analyze the effect of aging on the coordination of catalase (CAT) and ascorbate peroxidase (APX) antioxidant systems in safflower and sunflower. . Therefore, seeds were subjected to accelerated aging for 3, 6 and 9 days and grown in moistened paper towel for 72 hours. Additionally, before accelerated aging, sunflower seeds were pretreated by osmopriming with 10 mM ascorbate (ASC) or 3 amino 1,2,4 triazol (3-AT), a specific inhibitor of CAT activitie. The method of artificial aging used was efficient in both species, because it caused a decrease in germination, seedling development and growth, especially in safflower. The aging caused inhibition of CAT activity for both species and to compensate for such inhibition , sunflower increased mRNA expression of this enzyme , while safflower mobilized over the activity of APX. Analysis of the expression of malate synthase and sugar content demonstrated that sunflower seeds consumes lipid reserves in quiescent state, while the safflower is more dependent on carbohydrate. Pretreatment with 3-AT inhibited CAT activity and stimulated the APX, though with ASC acted reverse on these systems. None of the treatments recovered the physiological decline aging. It is concluded that aging change the oilseeds antioxidant metabolism, despite interspecies variations in response to this process, the depletion of the CAT antioxidant system was common. Because of this we propose that the measurement of CAT activity can be used to identify aging seed lots.

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Recentemente diversas técnicas de computação evolucionárias têm sido utilizadas em áreas como estimação de parâmetros de processos dinâmicos lineares e não lineares ou até sujeitos a incertezas. Isso motiva a utilização de algoritmos como o otimizador por nuvem de partículas (PSO) nas referidas áreas do conhecimento. Porém, pouco se sabe sobre a convergência desse algoritmo e, principalmente, as análises e estudos realizados têm se concentrado em resultados experimentais. Por isso, é objetivo deste trabalho propor uma nova estrutura para o PSO que permita analisar melhor a convergência do algoritmo de forma analítica. Para isso, o PSO é reestruturado para assumir uma forma matricial e reformulado como um sistema linear por partes. As partes serão analisadas de forma separada e será proposta a inserção de um fator de esquecimento que garante que a parte mais significativa deste sistema possua autovalores dentro do círculo de raio unitário. Também será realizada a análise da convergência do algoritmo como um todo, utilizando um critério de convergência quase certa, aplicável a sistemas chaveados. Na sequência, serão realizados testes experimentais de maneira a verificar o comportamento dos autovalores após a inserção do fator de esquecimento. Posteriormente, os algoritmos de identificação de parâmetros tradicionais serão combinados com o PSO matricial, de maneira a tornar os resultados da identificação tão bons ou melhores que a identificação apenas com o PSO ou, apenas com os algoritmos tradicionais. Os resultados mostram a convergência das partículas em uma região delimitada e que as funções obtidas após a combinação do algoritmo PSO matricial com os algoritmos convencionais, apresentam maior generalização para o sistema apresentado. As conclusões a que se chega é que a hibridização, apesar de limitar a busca por uma partícula mais apta do PSO, permite um desempenho mínimo para o algoritmo e ainda possibilita melhorar o resultado obtido com os algoritmos tradicionais, permitindo a representação do sistema aproximado em quantidades maiores de frequências.

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The great interest in nonlinear system identification is mainly due to the fact that a large amount of real systems are complex and need to have their nonlinearities considered so that their models can be successfully used in applications of control, prediction, inference, among others. This work evaluates the application of Fuzzy Wavelet Neural Networks (FWNN) to identify nonlinear dynamical systems subjected to noise and outliers. Generally, these elements cause negative effects on the identification procedure, resulting in erroneous interpretations regarding the dynamical behavior of the system. The FWNN combines in a single structure the ability to deal with uncertainties of fuzzy logic, the multiresolution characteristics of wavelet theory and learning and generalization abilities of the artificial neural networks. Usually, the learning procedure of these neural networks is realized by a gradient based method, which uses the mean squared error as its cost function. This work proposes the replacement of this traditional function by an Information Theoretic Learning similarity measure, called correntropy. With the use of this similarity measure, higher order statistics can be considered during the FWNN training process. For this reason, this measure is more suitable for non-Gaussian error distributions and makes the training less sensitive to the presence of outliers. In order to evaluate this replacement, FWNN models are obtained in two identification case studies: a real nonlinear system, consisting of a multisection tank, and a simulated system based on a model of the human knee joint. The results demonstrate that the application of correntropy as the error backpropagation algorithm cost function makes the identification procedure using FWNN models more robust to outliers. However, this is only achieved if the gaussian kernel width of correntropy is properly adjusted.

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The patient safety is a major concern in health services for its global dimension, as evidenced by the fragility of care processes that predispose an occurrence of adverse events. These events in a neonatal intensive care unit are considered serious and hazardous to lives of newborns. The present study aimed to identify and analyze adverse events in a neonatal intensive care unit based in Trigger Tool. It is an epidemiological, cross-sectional , exploratory, retrospective study with quantitative, descriptive and analytical approach, performed in 2015 at a school hospital. The sample was not probabilistic, involving 116 newborns who met the eligibility criteria. Data collection was performed by retrospective review of medical records, using a specific kind of "trigger" instrument, composed of sentinel events in neonatology, adapted from the American model used by the Vermont-Oxford Network. Data were analyzed using descriptive and inferential statistics. The chi-square test for linear trend was used to assess the associations between the variables of interest. The research received a favorable agreement from Ethics Committee of the Federal University of Rio Grande do Norte, under number 1055533, and Presentation Certificate for Ethics Assessment 43894515.6.0000.5537. The results show among investigated newborns, 110 experienced at least one adverse event during their stay, with a total of 391 medical records analyzed and rate of 3.37 events per patient. Prevailed the preterm newborns with low birth weight, from mother who had hypertensive diseases during pregnancy and urinary tract infection. The average hospitalization time was 25 days, associated with hospital-acquired infections events (p = 0.01). Among the identified adverse events stood out the events related to thermoregulation disorders (39.0%), with prevalence of hypothermia (26.0%), followed by health care-related infections (16.4%) and blood glucose disorders, hypoglycemia (9.00%) and hyperglycemia (6.64%). Most of these incidents were classified in categories E and F, which represents that there was damage small proportion. Due to these damages come from the care practice with newborn, 78% were classified as avoidable. There was statistically significant association between the variable birth weight with infections (p = 0.006) as well as peri/intraventricular bleeding (p = 0.02), hypoglycemia (p = 0.021), hyperglycemia (p = 0.001), hyperthermia (p = 0.39) and death (p=0,02). Gestational age was associated with seizures (p = 0.002), hyperglycemia (p=0.017) e hyperthermia (p=0.027). The security institution culture was reported by the health workers as intermediate, even though the number of adverse events found in only one unit of service indicates that there is much to be done. Thus the high rate of adverse events identified in the neonatal intensive care unit reinforces the necessity to elaborate specific preventive strategies for this risk environment.

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The patient safety is a major concern in health services for its global dimension, as evidenced by the fragility of care processes that predispose an occurrence of adverse events. These events in a neonatal intensive care unit are considered serious and hazardous to lives of newborns. The present study aimed to identify and analyze adverse events in a neonatal intensive care unit based in Trigger Tool. It is an epidemiological, cross-sectional , exploratory, retrospective study with quantitative, descriptive and analytical approach, performed in 2015 at a school hospital. The sample was not probabilistic, involving 116 newborns who met the eligibility criteria. Data collection was performed by retrospective review of medical records, using a specific kind of "trigger" instrument, composed of sentinel events in neonatology, adapted from the American model used by the Vermont-Oxford Network. Data were analyzed using descriptive and inferential statistics. The chi-square test for linear trend was used to assess the associations between the variables of interest. The research received a favorable agreement from Ethics Committee of the Federal University of Rio Grande do Norte, under number 1055533, and Presentation Certificate for Ethics Assessment 43894515.6.0000.5537. The results show among investigated newborns, 110 experienced at least one adverse event during their stay, with a total of 391 medical records analyzed and rate of 3.37 events per patient. Prevailed the preterm newborns with low birth weight, from mother who had hypertensive diseases during pregnancy and urinary tract infection. The average hospitalization time was 25 days, associated with hospital-acquired infections events (p = 0.01). Among the identified adverse events stood out the events related to thermoregulation disorders (39.0%), with prevalence of hypothermia (26.0%), followed by health care-related infections (16.4%) and blood glucose disorders, hypoglycemia (9.00%) and hyperglycemia (6.64%). Most of these incidents were classified in categories E and F, which represents that there was damage small proportion. Due to these damages come from the care practice with newborn, 78% were classified as avoidable. There was statistically significant association between the variable birth weight with infections (p = 0.006) as well as peri/intraventricular bleeding (p = 0.02), hypoglycemia (p = 0.021), hyperglycemia (p = 0.001), hyperthermia (p = 0.39) and death (p=0,02). Gestational age was associated with seizures (p = 0.002), hyperglycemia (p=0.017) e hyperthermia (p=0.027). The security institution culture was reported by the health workers as intermediate, even though the number of adverse events found in only one unit of service indicates that there is much to be done. Thus the high rate of adverse events identified in the neonatal intensive care unit reinforces the necessity to elaborate specific preventive strategies for this risk environment.