Dynamic Measurement System for Dipoles of RCS for CS

A dynamic measurement system was developed by the Institute of Modern Physics (IMP) for the dipole prototype of Rapid Cycle Synchrotron (RCS) of China Spallation Neutron Source (CSNS). The repetition frequency of RCS is 25 Hz. The probe is a moving arc searching-coil, and the data acquisition system is based on the dynamic analysis modular of National Instrument. To get the error of high order harmonics of the field at basic frequency, the hardware integrator is replaced by a high speed ADC with software filter and integrator. A series of harmonic coefficients of field are used to express the varieties of dynamic fields in space and time simultaneously. The measurement system has been tested in Institute of High Energy Physics (IHEP), and the property of the dipole prototype of RCS has been measured. Some measurement results and the repeatability of system are illustrated in this paper.

高速多道脉冲分析系统研究

多道脉冲分析系统是射线分析仪器的核心部件，有着广泛用途。许多应用领域对其性能指标的要求日益提高。目前我国尚不能制造高性能指标的产品。我们的主要目标是在保证一定的脉冲分析精度的同时，提高脉冲分析速度，改进系统的控制，提高系统集成度。本文首先回顾近年来多道脉冲分析系统（MCA）的研究进展。然后，着重阐述新型高速多道脉冲分析系统各部分的原理与结构。其主要特点在于：（1）系统集成度大大提高，使用灵活；（2）改进了电容充放电回路，实现了恒流充放电，提高了脉冲峰值保持精度；（3）在合理分配系统各部分功能的基础上，独立提出了新的MCA状态机模型，实现了对整个系统的简单、灵活而全面的控制，使之成为一个基本自封的系统，并且使脉冲分析速度有较大提高；（4）给出一个新的数据传输总线和数据采集接口的初步方案。本文第三部分论述了作者对器件的选择和运用，电路的设计和布局等问题的考虑。本文侧重从硬件角度研究多道脉冲分析系统。设计的系统结构为后续的软件研制工作提供了便利。

多路信号处理与QDC门信号产生逻辑插件的研制

本论文描述了多路信号处理与QDC（电荷数字转换器）门信号产生逻辑插件的研制过程。该逻辑插件的逻辑电路和模拟电路都经过了精心的设计和调试。核物理研究沿着激发能、核自旋及核同位旋三个自由度深入开展，产生了核物理研究中许多新的前沿领域。随着入射能量的增加，开放的反应道增多，多重探测器投入使用，使核物理实验的数据参数已经从几十路上升到上千路，即需要电子学工作者研制和开发一些高速触发、高密度、高稳定性的电子学硬件系统。本论文描述的多路信号处理与QDC门信号产生逻辑插件，主要用于产生QDC的开门信号。该电路系统早十六路并行、独立的高速放大单元电路、高速比较单元电路、延迟和脉宽成形单元电路、逻辑信号扇出单元电路、触发指示单元电路及多路模拟信号求和单元电路构成。该逻辑插件可接收≥ 20mv的小辐度输入信号而产生32路标准ECL（高电平-0.8V，低电平-1.6V）互补输出逻辑信号。输出ECL逻辑信号用于产生QDC的门控信号。该插件的多路模拟信号求和单元电路对每路输入信号可产生幅度为50mv的输出信号。该输出信号可用于多重符衙事件的鉴别和产生trigger触发信号。总的来说，多路辐度信号处理与QDC门信号产生逻辑插件不仅适用于重离子核物理实验中产生QDC开门信号，也可用于其它核物理实验的多重符合事件的鉴别。该插件的研制成功为多参数获取系统提供了一个良发的前端硬件设备。

Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry

Since protein phosphorylation is a dominant mechanism of information transfer in cells, there is a great need for methods capable of accurately elucidating sites of phosphorylation. In recent years mass spectrometry has become an increasingly viable alternative to more traditional methods of phosphorylation analysis. The present study used immobilized metal affinity chromatography (IMAC coupled with a linear ion trap mass spectrometer to analyze phosphorylated proteins in mouse liver. A total of 26 peptide sequences defining 26 sites of phosphorylation were determined. Although this number of identified phosphoproteins is not large, the approach is still of interest because a series of conservative criteria were adopted in data analysis. We note that, although the binding of non-phosphorylated peptides to the IMAC column was apparent, the improvements in high-speed scanning and quality of MS/MS spectra provided by the linear ion trap contributed to the phosphoprotein identification. Further analysis demonstrated that MS/MS/MS analysis was necessary to exclude the false-positive matches resulting from the MS/MS experiments, especially for multiphosphorylated peptides. The use of the linear ion trap considerably enabled exploitation of nanoflow-HPLC/MS/MS, and in addition MS/MS/MS has great potential in phosphoproteome research of relatively complex samples. Copyright (C) 2004 John Wiley Sons, Ltd.

Capillary array electrophoresis with confocal fluorescence rotary scanner

A capillary array electrophoresis system with rotary corifocal fluorescence scanner was reported. High speed direct current rotary motor combined with a rotary encoder and the reflection mirror has been designed to direct exactly the excitation laser beam. to the array of capillaries, which are symmetrically distributed around the motor. The rotary encoder is introduced to accurately orient the position of each capillary and its output signal triggers the data acquiring system to record. the fluorescence signal corresponding to each capillary. Separations of several amino acids are demonstrated by eight-channel capillary array electrophoresis built by ourselves.