Epilepsy priorities in Europe: A report of the ILAE-IBE Epilepsy Advocacy Europe Task Force.

The European Forum on Epilepsy Research (ERF2013), which took place in Dublin, Ireland, on May 26-29, 2013, was designed to appraise epilepsy research priorities in Europe through consultation with clinical and basic scientists as well as representatives of lay organizations and health care providers. The ultimate goal was to provide a platform to improve the lives of persons with epilepsy by influencing the political agenda of the EU. The Forum highlighted the epidemiologic, medical, and social importance of epilepsy in Europe, and addressed three separate but closely related concepts. First, possibilities were explored as to how the stigma and social burden associated with epilepsy could be reduced through targeted initiatives at EU national and regional levels. Second, ways to ensure optimal standards of care throughout Europe were specifically discussed. Finally, a need for further funding in epilepsy research within the European Horizon 2020 funding programme was communicated to politicians and policymakers participating to the forum. Research topics discussed specifically included (1) epilepsy in the developing brain; (2) novel targets for innovative diagnostics and treatment of epilepsy; (3) what is required for prevention and cure of epilepsy; and (4) epilepsy and comorbidities, with a special focus on aging and mental health. This report provides a summary of recommendations that emerged at ERF2013 about how to (1) strengthen epilepsy research, (2) reduce the treatment gap, and (3) reduce the burden and stigma associated with epilepsy. Half of the 6 million European citizens with epilepsy feel stigmatized and experience social exclusion, stressing the need for funding trans-European awareness campaigns and monitoring their impact on stigma, in line with the global commitment of the European Commission and with the recommendations made in the 2011 Written Declaration on Epilepsy. Epilepsy care has high rates of misdiagnosis and considerable variability in organization and quality across European countries, translating into huge societal cost (0.2% GDP) and stressing the need for cost-effective programs of harmonization and optimization of epilepsy care throughout Europe. There is currently no cure or prevention for epilepsy, and 30% of affected persons are not controlled by current treatments, stressing the need for pursuing research efforts in the field within Horizon 2020. Priorities should include (1) development of innovative biomarkers and therapeutic targets and strategies, from gene and cell-based therapies to technologically advanced surgical treatment; (2) addressing issues raised by pediatric and aging populations, as well as by specific etiologies and comorbidities such as traumatic brain injury (TBI) and cognitive dysfunction, toward more personalized medicine and prevention; and (3) translational studies and clinical trials built upon well-established European consortia.

Soldiers in a stingless bee: work rate and task repertoire suggest they are an elite force

The differentiation of workers into morphological subcastes (e.g., soldiers) represents an important evolutionary transition and is thought to improve division of labor in social insects. Soldiers occur in many ant and termite species, where they make up a small proportion of the workforce. A common assumption of worker caste evolution is that soldiers are behavioral specialists. Here, we report the first test of the "rare specialist" hypothesis in a eusocial bee. Colonies of the stingless bee Tetragonisca angustula are defended by a small group of morphologically differentiated soldiers. Contrary to the rare specialist hypothesis, we found that soldiers worked more (+34%-41%) and performed a greater variety of tasks (+23%-34%) than other workers, particularly early in life. Our results suggest a "rare elite" function of soldiers in T. angustula, that is, that they perform a disproportionately large amount of the work. Division of labor was based on a combination of temporal and physical castes, but soldiers transitioned faster from one task to the next. We discuss why the rare specialist assumption might not hold in species with a moderate degree of worker differentiation.

Elaboració d'un manual d'implantació del sistema APPCC per a microcerveseries

L’objectiu del treball ha estat elaborar un manual d’implantació del sistema d'Anàlisi de Perills i Punts Crítics de Control (APPCC) que serveixi de guia a les microcerveseries. En la primera part del manual s’ha realitzat una introducció on s’expliquen els orígens del sistema i es defineix l’APPCC com un sistema que permet identificar, avaluar i controlar els perills significatius en totes les fases de producció, transformació i distribució amb l’objectiu de garantir la innocuïtat dels aliments. Seguidament, s’ha mostrat la importància del Codex Alimentarius, on es troben descrites les directives per a l’aplicació del sistema d’APPCC. També s’ha indicat que el Reglament CE 852/2004, relatiu a la higiene dels productes alimentaris, obliga a les empreses alimentaries a crear, implementar i mantenir procediments permanents basats en els principis del sistema d’APPCC. Posteriorment, s’han exposat els aspectes que cal considerar per a poder implantar un sistema d’APPCC en una microcerveseria. S’han descrit aspectes com el marc legal del sector cerveser, la flexibilitat en l’aplicació del sistema d’autocontrol en les microempreses i els prerequisits. En l’annex 1, s’han desenvolupat els prerequisits necessaris per a les microcerveseries, i en l’annex 2, s’han mostrat exemples de registres derivats de la seva aplicació. Els prerequisits són bàsics per assegurar un entorn i unes condicions de treball higièniques, reduint o eliminant perills de contaminació en els aliments. Els prerequisits consideren els perills generals de l’entorn de treball. En canvi, l’APPCC considera els perills específics del procés de producció. Tot seguit, s’han definit els principis bàsics i les directrius per a l’aplicació del sistema d’APPCC descrits en el Codex Alimentarius, explicant les diferents fases que cal seguir per a la correcta implantació del sistema d’autocontrol. En la segona part del manual, s’ha desenvolupat el sistema d’APPCC per al procés d’elaboració de la cervesa artesana

WM Program manual

This manual describes how to run the new produced GUI C++ program that so called'WM' program. Section two describes the instructions of the program installation.Section three illustrates test runs description including running the program WM,sample of the input, output files, in addition to some generated graphs followed by the main form of the program created by using the Borland C++ Builder 6.

Opinion Mining

In this thesis we study the field of opinion mining by giving a comprehensive review of the available research that has been done in this topic. Also using this available knowledge we present a case study of a multilevel opinion mining system for a student organization's sales management system. We describe the field of opinion mining by discussing its historical roots, its motivations and applications as well as the different scientific approaches that have been used to solve this challenging problem of mining opinions. To deal with this huge subfield of natural language processing, we first give an abstraction of the problem of opinion mining and describe the theoretical frameworks that are available for dealing with appraisal language. Then we discuss the relation between opinion mining and computational linguistics which is a crucial pre-processing step for the accuracy of the subsequent steps of opinion mining. The second part of our thesis deals with the semantics of opinions where we describe the different ways used to collect lists of opinion words as well as the methods and techniques available for extracting knowledge from opinions present in unstructured textual data. In the part about collecting lists of opinion words we describe manual, semi manual and automatic ways to do so and give a review of the available lists that are used as gold standards in opinion mining research. For the methods and techniques of opinion mining we divide the task into three levels that are the document, sentence and feature level. The techniques that are presented in the document and sentence level are divided into supervised and unsupervised approaches that are used to determine the subjectivity and polarity of texts and sentences at these levels of analysis. At the feature level we give a description of the techniques available for finding the opinion targets, the polarity of the opinions about these opinion targets and the opinion holders. Also at the feature level we discuss the various ways to summarize and visualize the results of this level of analysis. In the third part of our thesis we present a case study of a sales management system that uses free form text and that can benefit from an opinion mining system. Using the knowledge gathered in the review of this field we provide a theoretical multi level opinion mining system (MLOM) that can perform most of the tasks needed from an opinion mining system. Based on the previous research we give some hints that many of the laborious market research tasks that are done by the sales force, which uses this sales management system, can improve their insight about their partners and by that increase the quality of their sales services and their overall results.

Catálogo sinóptico manual y causas atmosféricas de la precipitación en la provincia de Alicante

El estudio climático del régimen pluviométrico, y al mismo tiempo de la variabilidad de las precipitaciones, ha acaparado un punto de atención prioritario de las investigaciones que, sobre Climatología Mediterránea, han visto la luz para la fachada oriental de la península Ibérica durante los últimos lustros. Empero, no son muchos los trabajos que se han preocupado en cuantificar de forma estadística la precipitación en función de la causa atmosférica que la ha originado. En estrecha relación con ello, la presente investigación plantea un catálogo manual de clasificación de las situaciones atmosféricas que causan precipitación en la provincia de Alicante, distinguiendo tres grandes grupos: Episodios atlánticos, convectivos y mediterráneos. Bajo este planteamiento metodológico y algún otro más adicional, se analiza el comportamiento y características de todos los sucesos atmosféricos con precipitación ≥ 10 mm durante la década 1991-2000, para un total de seis observatorios meteorológicos. Se destaca el dominio de las lluvias mediterráneas en todos ellos, el importante peso de las precipitaciones de origen convectivo en el interior y, a grandes rasgos, la pobre eficacia pluviométrica de las situaciones atlánticas para la totalidad del territorio alicantino.

Design and Comparison оf Mixed Hinf/H2 Controller fоr АMB System

This master’s thesis is focused on the active magnetic bearings control, specifically the robust control. As carrying out of such kind of control used mixed H2/Hinf controller. So the goal of this work is to design it using Robust Control Toolbox™ in MATLAB and compare it performance and robustness with Hinf robust controller characteristics. But only one degree-of-freedom controller considered.

Drag force and frictional resistances in vertically vibrated dense granular media

The objective of this thesis is to shed light on the vertical vibration of granular materials for potential interest in the power generation industry. The main focus is investigating the drag force and frictional resistance that influence the movement of a granular material (in the form of glass beads) contained in a vessel, which is subjected to sinusoidal oscillation. The thesis is divided into three parts: theoretical analysis, experiments and computer simulations. The theoretical part of this study presents the underlying physical phenomena of the vibration of granular materials. Experiments are designed to determine fundamental parameters that contribute to the behavior of vibrating granular media. Numerical simulations include the use of three different software applications: FLUENT, LS-DYNA and ANSYS Workbench. The goal of these simulations is to test theoretical and semiempirical models for granular materials in order to validate their compatibility with the experimental findings, to assist in predicting their behavior, and to estimate quantities that are hard to measure in laboratory.

Implantació d’un manual de gestió en una indústria de llescats

Estudi sobre la implantació d’un manual de gestió en una indústria dellescats, realitzat a l’empresa Serra&Mota de la Cellera de Ter (consta d’un sistema APPCC i un manual de qualitat)

Celulas solares y sistemas fotovoltaicos. Manual de prácticas

Manual de prácticas de la asignatura optativa

Dynamic electrostatic force microscopy in liquid media

We present the implementation of dynamic electrostatic force microscopy in liquid media. This implementation enables the quantitative imaging of local dielectric properties of materials in electrolyte solutions with nanoscale spatial resolution. Local imaging capabilities are obtained by probing the frequency-dependent and ionic concentration-dependent electrostatic forces at high frequency (>1 MHz), while quantification of the interaction forces is obtained with finite-element numerical calculations. The results presented open a wide range of possibilities in a number of fields where the dielectric properties of materials need to be probed at the nanoscale and in a liquid environment.

Dynamic electrostatic force microscopy in liquid media

We present the implementation of dynamic electrostatic force microscopy in liquid media. This implementation enables the quantitative imaging of local dielectric properties of materials in electrolyte solutions with nanoscale spatial resolution. Local imaging capabilities are obtained by probing the frequency-dependent and ionic concentration-dependent electrostatic forces at high frequency (>1 MHz), while quantification of the interaction forces is obtained with finite-element numerical calculations. The results presented open a wide range of possibilities in a number of fields where the dielectric properties of materials need to be probed at the nanoscale and in a liquid environment.