Estudo hodológico e neuroquímico das aferências da região noradrenérgica A5 aos neurônios da raiz coclear

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Efeito protetor da coenzima Q10 sobre os danos oxidativos da L-Tiroxina no músculo sóleo de ratos: Fabiana Barreiro de Freitas Silva. -

Pós-graduação em Ciência Animal - FMVA

Indicadores de estresse, ansiedade e depressão de mães de bebês com risco ao desenvolvimento

Pós-graduação em Psicologia do Desenvolvimento e Aprendizagem - FC

Efeitos da Exenatida e da Sitagliptina durante a indução da periodontite em ratos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Sistema NPPC-NPR2 na espécie bovina: identificação em folículos antrais e modulação na concentração de nucleotídeos cíclicos e na expressão gênica de PDE3 em complexos cumulus-oócito

Pós-graduação em Biociências - FCLAS

Identificação de funções de transferência de ordem fracionária utilizando como entrada um degrau

Pós-graduação em Engenharia Elétrica - FEIS

Efeitos preventivos do treinamento físico na expressão das proteínas Cox-2 e Vegf de ratos tratados com dexametasona

Dexamethasone is a synthetic glucocorticoid widely used to treat allergic and inflammatory processes. This drug is used in three main situations, are used to contain acute or chronic inflammatory processes, or like immunosuppressive drug's. In these cases the patient will receive high doses for a chronic period and, therefore, has a much greater chance of adverse side effects, such as hypertension, diabetes and dyslipidemia. Dexamethasone promotes deleterious effects on the arachidonic acid pathway, when administered in high doses, because it is a potent anti-inflammatory drug. We recently demonstrated that dexamethasone significantly reduces the protein expression of vascular endothelial growth factor (VEGF) in both skeletal muscle and heart, but the mechanisms involved remain unclear. Meanwhile, exercise has been shown to be effective against high blood pressure, diabetes and dyslipidemia, promoting, among other factors, the increase in VEGF and angiogenesis. One possible explanation for these effects would be the creation of new vessels mediated by inflammation, or by the stimulation of the formation of products of the metabolism of arachidonic acid (AA), such as prostaglandin E2 (PGE2) and VEGF, by increasing the stimulation of the enzymes cyclooxygenase 1 and 2 (COX-1 and COX-2). Little is known about the preventive effects of training on the action of dexamethasone in the arachidonic acid pathway. Therefore, the aim of this study was to determine whether aerobic exercise training, performed before and concomitant treatment with dexamethasone, was able to prevent the effects of the dexamethasone in the protein expression of COX-2 and VEGF. For this, we used young Wistar rats (n = 40) which were randomly divided into 4 groups: sedentary control (SC), sedentary and treated with dexamethasone (SD), trained control (TC) and trained and treated with dexamethasone (TD). These rats performed aerobic exercise training, 60% of maximum capacity, 5

Natação e desenvolvimento motor em idade escolar

Swimming is a sport well suited to any age group, it worked properly when the individual stimuli that provides assist in human development. But water stimulation, is not something that is so easily in physical education in Brazil. Development corresponds to changes that occur throughout life, but that depends on the stimuli provided. Several studies have shown positive effects of swimming in relation to the child. This study aimed to verify if children swimmers and physical education classes have better motor development than those who do not practice the sport. Collection was done with two groups of 10 students between 9 and 11 years. As a group consisting of non-swimmers, and another formed by those that complement the physical education class with the regular practice of swimming. To develop the study was administered a battery of the proposed motor adapted Rosa Neto (2002) in which each child performed tasks corresponding to their chronological age (CA) and were only able to perform the task at a later age, when it was obtained successful in completing the task as originally proposed. At the end of the application of all statistical tests was done getting mean and standard deviation of the old motor (IM), calculated the ratio General Motor (MGQ) for the classification of the child's motor development and application of the t test with p <0.05 to observe the level of significance in the results. The results showed that the group swimmers had better agility tests which resulted in a difference between (IC) and (IM) higher compared with the non-practitioner. They also had higher average (MGQ), but these were not sufficient to classify the group into another level of development, however, by observing isolated cases, two children that practice would be a greater level of development. Through the t test was observed that the group swimmers had significant difference in balance ability. We conclude that the swimming group got positive overall...

Efeito da coenzima Q10 nos danos oxidativos induzidos pela L-tiroxina no músculo sóleo de ratos

Introduction: skeletal muscles are dynamic tissue that can change their phenotypic characteristics providing a better functional adaptation to different stimuli. L-thyroxine is a hormone produced by the thyroid gland and has been used as an experimental model for stimulation of oxidative stress in skeletal muscle. Coenzyme Q10 (CoQ10) is a fat-soluble provitamin endogenously synthesized and found naturally in foods such red meat, fish, cereals, broccoli and spinach. It has antioxidant properties and potential in the treatment of degenerative and neuromuscular diseases. Objective: to evaluate the protective effect of CoQ10 in the soleus muscle of rats against the oxidative damage caused by L-thyroxine. Methods: the rats were divided in four groups of six animals each: Group 1 (control); Group 2 (coenzyme Q10); Group 3 (L-thyroxine), and Group 4 coenzyme Q10 and L-thyroxine). After euthanasia, blood was collected and serum activity of the enzymes creatine kinase (CK) and aspartate aminotransferase (AST) was analyzed. In the soleus muscle homogenates the factors related to oxidative stress were assessed. Results: CoQ10 protected the soleus muscle against the damage caused by L-thyroxine and favored the maintenance of the antioxidant enzymes glutathione reductase and glutathione peroxidase, the concentration of decreased and oxidized glutathione, and prevented lipid peroxidation. Conclusion: the results indicate that CoQ10 protects rat soleus muscle from oxidative damage caused by L-thyroxine.

Obesity does not lead to imbalance between myocardial phospholamban phosphorylation and dephosphorylation

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The importance of retesting the hearing screening as an indicator of the real early hearing disorder

Early diagnosis of hearing loss minimizes its impact on child development. We studied factors that influence the effectiveness of screening programs. To investigate the relationship between gender, weight at birth, gestational age, risk factors for hearing loss, venue for newborn hearing screening and pass and fail results in the retest. Prospective cohort study was carried out in a tertiary referral hospital. The screening was performed in 565 newborns through transient evoked otoacoustic emissions in three admission units before hospital discharge and retest in the outpatient clinic. Gender, weight at birth, gestational age, presence of risk indicators for hearing loss and venue for newborn hearing screening were considered. Full-term infants comprised 86% of the cases, preterm 14%, and risk factors for hearing loss were identified in 11%. Considering the 165 newborns retested, only the venue for screening, Intermediate Care Unit, was related to fail result in the retest. Gender, weight at birth, gestational age and presence of risk factors for hearing loss were not related to pass and/or fail results in the retest. The screening performed in intermediate care units increases the chance of continued fail result in the Transient Otoacoustic Evoked Emissions test.

Aplicações médicas das abordagens complexas não lineares: a geometria fractal do EEG

Pós-graduação em Saúde Coletiva - FMB

Tratamento da síndrome do túnel do carpo com laser

Pós-graduação em Bases Gerais da Cirurgia - FMB

Correlações entre padrões hematológicos, parasitológicos e desempenho animal de ovelhas suplementadas com gordura protegida

The development of populations of gastrointestinal parasites resistant to antihelmintics has led to seeks new alternatives its control. Stimulation of natural immunity by means of animal nutrition has shown promising results in controlling nematodes in sheep. The addition of protected fat sources, containing essential fatty acids, may be an alternative due to many effects, among them, regulation of immunity expression and regulation of the inflammatory response by immune effectors. The aim of this study was to estimate correlations between haematological and parasitological patterns, animal performance through weight and body condition, under the influence of protected fat in ewes. Fifty Santa Ines sheep, in the final third of pregnancy or postpartum, in paddocks of Panicum maximum, received, individually, 200 g per day of concentrate, isonitrogenous and isocaloric diets, with or without the addition of protected fat. In general, except for total leukocytes and eosinophils, almost all of Pearson correlation coefficients of other variables were significant. However, the protected fat, in the amount offered, had no antihelmintic effect.

Anestesia peribulbar para enucleação em um felino: relato de caso

Foi atendido no Hospital Veterinário “Luiz Quintiliano de Oliveira”, o felino Nick, SRD, de quatro meses de idade, pesando 700 gramas, com histórico de trauma por arranhadura em bulbo ocular esquerdo. Ao exame físico específico, evidenciou-se úlcera profunda e prolapso de íris, sendo então indicada a enucleação. Ao exame físico geral, observou-se freqüência cardíaca (FC) de 160 batimentos.min-1, frequência respiratória (f) de 80 movimentos.min-1, tempo de preenchimento capilar menor do que dois segundos, temperatura retal (TR) de 39,2oC e mucosas normocoradas. Como medicação pré-anestésica, empregou-se acepromazina (0,04 mg.kg-1) e metadona (0,3 mg.kg-1), administradas pela via intramuscular. A veia femoral esquerda foi cateterizada com cateter 24G para administração de Ringer com Lactato de sódio (10 mL.kg-1.h- 1 ). A indução foi realizada por máscara facial tendo-se como agente o isofluorano em fluxo diluente de 100 mL.kg-1.min-1 de oxigênio a 100%, seguida de intubação orotraqueal com sonda n o 2,5 sem cuff. Seguiu-se a manutenção anestésica com a mesma mistura da indução, administrada por meio de circuito anestésico sem reinalação de gases, do tipo Baraka, mantendose o paciente sob ventilação assistida. Ato contínuo, realizou-se a técnica anestésica peribulbar de punção única inferior, utilizando-se lidocaína 2% com vasoconstritor (3mg.kg-1) associada a bupivacaína 0,5% sem vasoconstritor (0,8mg.kg-1), perfazendo um volume total de 0,3ml.kg-1 . Uma agulha 13x4,5 foi introduzida em todo o seu comprimento com o bisel voltado para a órbita, no terço lateral do fórnice conjuntival inferior da órbita esquerda, administrando-se a associação dos agentes anestésicos locais, seguida de compressão manual da área para facilitar a difusão dos mesmos. Durante o procedimento anestésico, realizou-se a monitoração da FC, f, pressão arterial sistólica (PAS), TR e saturação periférica da hemoglobina (SpO2). O tempo total de anestesia e cirurgia foi de 30 e 20 minutos, respectivamente, e a SpO2, concentração de isofluorano e TR mantiveram-se em 99±1%, 1,7±0,8% e 37,4±1,5oC, respectivamente. O plano anestésico manteve-se estável, sem a necessidade de resgate analgésico. Não houve a ocorrência de reflexo óculo-cardíaco (ROC) frente à manipulação do nervo óptico, o que pode ser atribuída provavelmente ao bloqueio peribulbar. A anestesia regional é frequentemente empregada para cirurgias oftálmicas em humanos, como a facoemulsificação, sendo que o manejo anestésico pode contribuir para o sucesso do procedimento. Pode-se concluir que, também na espécie felina, o bloqueio peribulbar pode ser uma boa alternativa para a realização de protocolos de anestesia balanceada para procedimentos oftálmicos.