Oxidative stress : emerging mitochondrial and cellular themes and variations in neuronal injury

Oxidative stress plays a central role in neuronal injury and cell death in acute and chronic pathological conditions. The cellular responses to oxidative stress embrace changes in mitochondria and other organelles, notably endoplasmic reticulum, and can lead to a number of cell death paradigms, which cover a spectrum from apoptosis to necrosis and include autophagy. In Alzheimer's disease, and other pathologies including Parkinson's disease, protein aggregation provides further cellular stresses that can initiate or feed into the pathways to cell death engendered by oxidative stress. Specific attention is paid here to mitochondrial dysfunction and programmed cell death, and the diverse modes of cell death mediated by mitochondria under oxidative stress. Novel insights into cellular responses to neuronal oxidative stress from a range of different stressors can be gained by detailed transcriptomics analyses. Such studies at the cellular level provide the key for understanding the molecular and cellular pathways whereby neurons respond to oxidative stress and undergo injury and death. These considerations underpin the development of detailed knowledge in more complex integrated systems, up to the intact human bearing the neuropathology, facilitating therapeutic advances.

Emerging technology for remote IED render safe using the OzBot

The Centre for Intelligent Systems Research (CISR) based within Deakin University’s Geelong campus has been developing technology specifically for remote render-safe of IED since being awarded a CTD contact in 2006. During this time, research engineers have worked with key defence and industry stakeholders to develop a series of robotic platforms tasked with immersing a soldier in his or her remote environment. Utilising Haptics (force feedback technology), stereovision (binocular video stream for depth perception) and intuitive user controls, the robots have been engineered to deliver maximum effectiveness while allowing minimal training liability. In Victoria, CISR’s OzBot series of mobile platforms have been used by the Victorian Police in a first-responder capacity, exploiting the 30-sec system boot-up and man-portable design to get eyes-on-target at the soonest possible moment. The CISR robotics group has been working on technologies that reduce operator fatigue, minimise training liability and maintenance, developing simulation technologies for increased training availability and develop mobile platforms with increased range, payload, manipulator reach and capability. This paper describes some of the technologies, methods and systems developed by CISR in the field of IED neutralisation with the aim of increasing military awareness of Australian capability.

The management of bipolar disorder in primary care : a review of existing and emerging therapies

Recent evidence suggests that the prevalence of bipolar disorder is as much as fivefold higher than previously believed, and may amount to nearly 5% of the population, making it almost as common as unipolar major depression. It is, therefore, not unrealistic to assume that primary care or family physicians will frequently encounter bipolar patients in their practice. Such patients may present with a depressive episode, for a variety of medical reasons, for longer-term maintenance after stabilization, and even with an acute manic episode. Whatever the reason, a working knowledge of current trends in the acute and longer-term management of bipolar disorder would be helpful to the primary care physician. In addition, an understanding of important side-effects and drug interactions that occur with drugs used to treat bipolar disorder, which may be encountered in the medical setting, are paramount. This paper will attempt to review existing and emerging therapies in bipolar disorder, as well as their common drug interactions and side-effects.

DIOXOLANE NORBORNANE / NORBORNENE COMPOUNDS SUITABLE AS ANTIMICROBIAL AGENTS TO TREAT BACTERIAL INFECTIONS

The invention provides a compound including : A core having a first face and a second face; A binding portion attached to the first face of the core, wherein the binding portion is capable of binding to an anionic group present in a cell membrane of a microorganism; and A hydrophobic portion attached to the second face of the core, wherein the hydrophobic portion is capable of interacting with the cell membrane of the microorganism; and The core comprises a dioxolane norbornane / norbornene of formula (II): Or a salt or ion thereof, wherein R' is a moiety forming part of a hydrophobic portion; R2 is a first binding portion; and R3 is a seconding binding portion. The invention also provides compositions including at least one such compound. The invention also provides methods and uses for treatment or prophylaxis of infection of a mammal by a microorganism, and methods and uses for treating or preventing contamination of a substrate by a microorganism, using the compounds and compositions.

What drives technology innovation among the emerging Chinese enterprises?

In the light of rapid development of technology/knowledge intensive firms arising from the emerging economy of China in recent time, this paper is aimed at developing an analytical framework, based on the institutional theory and resource-based view, to evaluate the drivers and antecedents of technology innovation among Chinese emerging multinational enterprises (MNEs). Use of case study approach, the study examined two large Chinese enterprises in Wuhan and found that a linear sequential pattern of technology innovation did not apply. In contrast, two enterprises investigated tended to combine several types of innovation (strategic cost, organisational and operational innovation) to manage their internal capabilities and other organisational activities and routines to change, learn, adapt and create technology innovation. Our finding in this study also suggests that the key factor for Chinese firms to be innovative is more internally driven by several human resource management strategies that helped build technological capabilities effectively. Main implications of this study are that organisational human resource managers, technology and system designers should work together to design and develop enterprise management systems conducive to enhance both technology and human creativity for emerging Chinese multinational enterprises.

Towards an extended international HRM model for emerging multinational enterprises

This paper critiques several exiting strategic international human resource management (SIHRM) frameworks and discusses their limitations to apply directly to emerging multinational enterprises (EMNEs), especially those generated from China and other BRICS nations. To complement the existing SIHRM frameworks, key variables relevant to emerging economies are identified and the extended model with particular reference to EMNEs is developed with several research propositions. It is believed that the extended model would better capture the recent development of MNEs in transition, and alert emerging international managers to address several human resource management challenges in the global context

What drives stock markets over short horizons? Evidence from emerging markets

The goal of this paper is to examine the importance of permanent and transitory shocks in explaining variations in stock prices for Singapore, Taiwan, and South Korea using a trend-cycle decomposition technique. This study is novel in that in measuring the impact of shocks we not only impose common trend restrictions but also common cycle restrictions. We later undertake a post-sample forecasting exercise to confirm the efficiency gains from imposing common cycle restrictions. We find that over short horizons, transitory shocks are the dominant source of variations in stock prices for South Korea, while permanent shocks explain the bulk of the variations in stock price of Singapore and Taiwan.

Emerging hypothesis verification using function-based geometric models and active vision strategies

This paper describes an investigation into the use of parametric 2D models describing the movement of edges for the determination of possible 3D shape and hence function of an object. An assumption of this research is that the camera can foveate and track particular features. It is argued that simple 2D analytic descriptions of the movement of edges can infer 3D shape while the camera is moved. This uses an advantage of foveation i.e. the problem becomes object centred. The problem of correspondence for numerous edge points is overcome by the use of a tree based representation for the competing hypotheses. Numerous hypothesis are maintained simultaneously and it does not rely on a single kinematic model which assumes constant velocity or acceleration. The numerous advantages of this strategy are described.

Book review : Entrepreneurship in emerging regions around the world : theory, evidence and implications

P.H. Phan, S. Venkataraman and S.R. Velamuri (2008) Entrepreneurship in emerging regions around the world: Theory, evidence and implications, Edward Elgar, Cheltenham, United Kingdom