940 resultados para drugmetabolism in old age, pharmacokinetiks


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Most of the helium-3 in oceanic sediments conies from interplanetary dust particles (IDPs), and can therefore be used to infer the accretion rate of dust to the Earth through time (Ozima et al., 1984, doi:10.1038/311448a0; Takayanagi and Ozima, 1987, doi:10.1029/JB092iB12p12531; Farley, 1995, doi:10.1038/376153a0). 3He records from slowly accumulating pelagic clays indicate that the accretion rate varies considerably over millions of years, probably owing to cometary and asteroidal break-up events3. Muller and MacDonald have proposed (Muller and MacDonald, 1995, doi:10.1038/377107b0) that periodic changes in this accretion rate due to a previously unrecognized 100-kyr periodicity in the Earth's orbital inclination might account for the prominence of this frequency in climate records of the past million years (Imbrie et al., 1993, doi:10.1029/93PA02751). Here we report variations in the 3He flux to the sea floor that support this idea. We find that the flux recorded in rapidly accumulating Quaternary sediments from the Mid-Atlantic Ridge oscillates with a period of about 100 kyr. We cannot yet say, however, whether the 100-kyr climate cycle is a consequence of, a cause of, or an effect independent of these periodic changes in the rate of delivery of interplanetary dust to the sea floor.

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AMS-14C dated sediment cores from the Ob and Yenisei estuaries and the adjacent inner Kara Sea were investigated to determine the siliclastic and organic carbon fluxes and their relationship to paleoenvironmental changes. The variability of sediment fluxes during Holocene times is related to the post-glacial sea-level rise and changes in river discharge and coastal erosion input. Whereas during the late/middle Holocene most of the terrigenous sediments were deposited in the estuaries and the areas directly off the estuaries, huge amounts of sediments accumulated on the Kara Sea shelf farther north during the early Holocene before about 9 Cal. kyrs. BP. The maximum accumulation at that time is related to the lowered sea level, increased coastal erosion, and increased river discharge due to the final stage of mountain deglaciation of the Putoran Massif. Increased supply of Yenisei-derived material indicated by peak magnetic susceptibility values probably occurred in climate-related pulses culminating near 11, 10, and 9 Cal. kyrs. BP. As sea level rose, the main Holocene depocenter migrated southward. Based on hydrogen index values and n-alkanes, the organic matter is predominantly of terrigenous origin. Maximum accumulation rates of 1.5 to more than 6 g/cm**2/y occurred in the early Holocene sediments, suggesting more humid climatic conditions with an increased vegetation cover in the source area at that time. In general, high organic carbon accumulation rates characterize the estuaries and the inner Kara Sea as important sink for terrigenous organic carbon. A high-resolution record of Holocene variability of magnetic susceptibility (MS) in an AMS14C-dated sediment core from the northern Yenisei estuary may indicate natural variability of Arctic climate change and river discharge on a centennial to millenial time scale. Short-term maxima in MS probably related to warmer climate, enhanced precipitation, intensified weathering/erosion and increased river discharge, display a frequency of about 300 to 700 years.

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Abundance variations of six Pliocene species of discoasters have been analyzed over the time interval from 1.89 to 2.95 Ma at five contrasting sites in the North Atlantic: Deep Sea Drilling Project Sites 552 (56°N) and 607 (41°N) and Ocean Drilling Program 658 (20°N), 659 (18°N), and 662 (1°S). A sampling interval equivalent to approximately 3 k.y. was used. Total Discoaster abundance showed a reduction with increasing latitude and from the effects of upwelling. This phenomenon is most obvious in Discoaster brouweri, the only species that survived over the entire time interval studied. Prior to 2.38 Ma, Discoaster pentaradiatus and Discoaster surculus are important components of the Discoaster assemblage: Discoaster pentaradiatus increases slightly with latitude up to 41°N, and its abundance relative to D. brouweri increases up to 56°N; D. surculus increases in abundance with latitude and with upwelling conditions relative to both D. brouweri and D. pentaradiatus and is dominant to the latter species at upwelling Site 658 and at the highest latitude sites. Discoaster asymmetricus and Discoaster tamalis appear to increase in abundance with latitude relative to D. brouweri. Many of the abundance changes observed appear to be connected with the initiation of glaciation in the North Atlantic at 2.4 Ma. The long-term trend of decreasing Discoaster abundance probably reflects the fall of sea-surface temperatures. This trend of cooling is overprinted by short-term variations that are probably associated with orbital forcing. Evidence for the astronomical elements of eccentricity and obliquity periodicities were found at all sites; however, only at Sites 607, 659, and 662 were precessional periodicities detected. Furthermore, only at Site 659 was precession found to be dominant to obliquity. Abundance peaks of individual species were found to cross-correlate between sites. The distinct abundance fluctuations observed especially in the tropics suggest that temperature is not the only factor responsible for this variation. This study reveals for the first time the importance of productivity pressure on the suppression of Discoaster abundance.

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The filling up of the lake which existed in the basin of the Trentelmoor (40 km E of Hannover, Germany) - in Preboreal times was finished 2000 years ago. Since then fen vegetation has covered the former lake's surface. The postglacial development of the vegetation follows the pattern which is typical of Central Europe. However, due to the poorness of the soils around the Trentelmoor, the frequencies of some tree species differ. Beech for example never reached - for the benefit of oak - that importance which this tree species usually gains on better soils. Human impact becomes recognisable in the upper Neolithic for the first time. The area has been settled continuously, but with changing intensities, throughout the last 3000 years. When the manuscript of this paper went to press the results of two radiocarbon age determinations only were completed. An additional three determinations were completed somewhat later. See the accompanying table for results.

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Three marine sediment cores distributed along the Norwegian (MD95-2011), Barents Sea (JM09-KA11-GC), and Svalbard (HH11-134-BC) continental margins have been investigated in order to reconstruct changes in the poleward flow of Atlantic waters (AW) and in the nature of upper surface water masses within the eastern Nordic Seas over the last 3000 yr. These reconstructions are based on a limited set of coccolith proxies: the abundance ratio between Emiliania huxleyi and Coccolithus pelagicus, an index of Atlantic vs. Polar/Arctic surface water masses; and Gephyrocapsa muellerae, a drifted coccolith species from the temperate North Atlantic, whose abundance changes are related to variations in the strength of the North Atlantic Current. The entire investigated area, from 66 to 77° N, was affected by an overall increase in AW flow from 3000 cal yr BP (before present) to the present. The long-term modulation of westerlies' strength and location, which are essentially driven by the dominant mode of the North Atlantic Oscillation (NAO), is thought to explain the observed dynamics of poleward AW flow. The same mechanism also reconciles the recorded opposite zonal shifts in the location of the Arctic front between the area off western Norway and the western Barents Sea-eastern Fram Strait region. The Little Ice Age (LIA) was governed by deteriorating conditions, with Arctic/Polar waters dominating in the surface off western Svalbard and western Barents Sea, possibly associated with both severe sea ice conditions and a strongly reduced AW strength. A sudden short pulse of resumed high WSC (West Spitsbergen Current) flow interrupted this cold spell in eastern Fram Strait from 330 to 410 cal yr BP. Our dataset not only confirms the high amplitude warming of surface waters at the turn of the 19th century off western Svalbard, it also shows that such a warming was primarily induced by an excess flow of AW which stands as unprecedented over the last 3000 yr.

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Broken Ridge, in the eastern Indian Ocean,is overlain by about 1600 m of middle Cretaceous to Pleistocene tuffaceous and carbonate sediments that record the oceanographic history of southern hemisphere mid-to high-latitude regions. Prior to about 42 Ma, Broken Ridge formed the northern part of the broad Kerguelen-Broken Ridge Plateau. During the middle Eocene, this feature was split by the newly forming Southeast Indian Ocean Ridge; since then, Broken Ridge has drifted north from about 55° to 31°S. The lower part of the sedimentary section is characterized by Turonian to Santonian tuffs that contain abundant glauconite and some carbonate. The tuffs record a large but apparently local volcanic input that characterized the central part of Broken Ridge into the early Tertiary. Maestrichtian shallow-water(several hundred to 1000 m depth) limestones and cherts accumulated at some of the highest rates ever documented from the open ocean, 4 to 5 g/cm**2/kyr. A complete (with all biostratigraphic zones) Cretaceous-Tertiary boundary section was recovered from site 752. The first 1.5 m.y. of the Tertiary is characterized by an order-of-magnitude reduction in the flux of biogenic sediments, indicating a period of sharply reduced biological productivity at 55°S, following which the carbonate and silica sedimentation rates almost reach the previous high values of the latest Cretaceous. We recovered a complete section through the Paleocene that contains all major fossil groups and is more than 300 m thick, perhaps the best pelagic Paleocene section encountered in ocean drilling. About 42 Ma, Broken Ridge was uplifted 2500 m in response to the intra-plateau rifting event; subsequent erosion and deposition has resulted in a prominent Eocene angular unconformity atop the ridge. An Oligocene disconformity characterized by a widespread pebble layer probably represents the 30 Ma sea-level fall. The Neogene pelagic ooze on Broken Ridge has been winnowed, and thus its grain size provides a direct physical record of the energy of the southern hemisphere drift current in the Indian Ocean for the past 30 m.y.

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Although grassland and savanna occupy only a quarter of the world's vegetation, burning in these ecosystems accounts for roughly half the global carbon emissions from fire. However, the processes that govern changes in grassland burning are poorly understood, particularly on time scales beyond satellite records. We analyzed microcharcoal, sediments, and geochemistry in a high-resolution marine sediment core off Namibia to identify the processes that have controlled biomass burning in southern African grassland ecosystems under large, multimillennial-scale climate changes. Six fire cycles occurred during the past 170,000 y in southern Africa that correspond both in timing and magnitude to the precessional forcing of north-south shifts in the Intertropical Convergence Zone. Contrary to the conventional expectation that fire increases with higher temperatures and increased drought, we found that wetter and cooler climates cause increased burning in the study region, owing to a shift in rainfall amount and seasonality (and thus vegetation flammability). We also show that charcoal morphology (i.e., the particle's length-to-width ratio) can be used to reconstruct changes in fire activity as well as biome shifts over time. Our results provide essential context for understanding current and future grassland-fire dynamics and their associated carbon emissions.

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Well-preserved diatoms are present in high sedimentation rate Pleistocene cores retrieved on Ocean Drilling Program (ODP) Legs 151, 152, 162 and IMAGES cruises of R/V Marion Dufresne from the North Atlantic. Investigation of the stratigraphic occurrence of diatom species shows that the youngest diatom event observed in the area is the last occurrence (LO) of Proboscia curvirostris (Jousé) Jordan and Priddle. P. curvirostris is a robust species that can easily be identified in the sediments, and therefore can be a practical biostratigraphic tool. We have mapped its areal distribution, and found that it stretches from 40°N to 80°N in the North Atlantic. Further, we have correlated the LO P. curvirostris to the oxygen isotope records of six cores to refine the age of this biostratigraphic event. The extinction of P. curvirostris is latitudinally diachronous through Marine Isotope Stages (MIS) 9 to 8 within the North Atlantic. This is closely related to the paleoceanography of the area. P. curvirostris first disappeared within interglacial MIS 9 (324 ka) from the northern areas that are most sensitive to climatic forcing, like the East Greenland current and the sea-ice margin. It survived in mid-North Atlantic until the conditions of the MIS 8 (glaciation) became too severe (260 ka). In the North Pacific at ODP Site 883 the LO P. curvirostris falls within MIS 8. The observed overlap in age between the North Atlantic and the North Pacific strongly suggests that the extinction of P. curvirostris is synchronous between these oceans.