Der jüdische Nationalismus

von Robert Stricker

Comparative assessment of a canine-specific medium to support colony formation from canine hair follicular keratinocytes.

BACKGROUND Follicular stem cells and their progeny are responsible for the cyclical renewal of hair follicles and maintenance of the hair coat. The understanding of pathways involved in this process is essential to elucidate the pathogenetic mechanisms of primary alopecia. Stem cells and their direct descendants are located in the bulge region of the isthmus of hair follicles. Although these cells have been studied extensively in mice and humans, data for canine isthmic keratinocyte activation and proliferation are not available. HYPOTHESIS/OBJECTIVES The aim was to establish an accurate and reliable in vitro system to study the growth potential of canine isthmic keratinocytes. We assessed the colony-promoting capability of a commercially available canine-specific medium, CELLnTEC (CnT-09), compared with a well-established home-made medium, complete FAD (cFAD). The CnT-09 medium is specific for the growth of canine keratinocytes, while the cFAD medium can support growth and colony formation of keratinocytes from several species. ANIMALS Skin biopsies were obtained from 15 recently euthanized dogs of various breeds with no skin abnormalities. METHODS The isthmic region of compound hair follicles was isolated by microdissection and cell growth monitored using several parameters with colony-forming assays. RESULTS The CnT-09 and cFAD media provided similar growth as measured by the total number and size of colonies, as well as rate of cell differentiation. CONCLUSIONS The commercial canine-specific CnT-09 medium was comparable to the home-made cFAD medium in supporting the growth and proliferation of canine follicular keratinocytes in vitro. The CnT-09 medium should be a viable alternative growth medium for molecular studies of alopecic disorders in dogs.

Kritische Reise durch Palästina

Alfred Wiener

Ms. hebr. oct. 167 - Ḥeshbon ha-luḥot

Vorbesitzer: Abraham Merzbacher

Novel Features of the Prenatal Horn Bud Development in Cattle (Bos taurus).

Whereas the genetic background of horn growth in cattle has been studied extensively, little is known about the morphological changes in the developing fetal horn bud. In this study we histologically analyzed the development of horn buds of bovine fetuses between ~70 and ~268 days of pregnancy and compared them with biopsies taken from the frontal skin of the same fetuses. In addition we compared the samples from the wild type (horned) fetuses with samples taken from the horn bud region of age-matched genetically hornless (polled) fetuses. In summary, the horn bud with multiple layers of vacuolated keratinocytes is histologically visible early in fetal life already at around day 70 of gestation and can be easily differentiated from the much thinner epidermis of the frontal skin. However, at the gestation day (gd) 212 the epidermis above the horn bud shows a similar morphology to the epidermis of the frontal skin and the outstanding layers of vacuolated keratinocytes have disappeared. Immature hair follicles are seen in the frontal skin at gd 115 whereas hair follicles below the horn bud are not present until gd 155. Interestingly, thick nerve bundles appear in the dermis below the horn bud at gd 115. These nerve fibers grow in size over time and are prominent shortly before birth. Prominent nerve bundles are not present in the frontal skin of wild type or in polled fetuses at any time, indicating that the horn bud is a very sensitive area. The samples from the horn bud region from polled fetuses are histologically equivalent to samples taken from the frontal skin in horned species. This is the first study that presents unique histological data on bovine prenatal horn bud differentiation at different developmental stages which creates knowledge for a better understanding of recent molecular findings.

Automated NNLL + NLO resummation for jet-veto cross sections

In electroweak-boson production processes with a jet veto, higher-order corrections are enhanced by logarithms of the veto scale over the invariant mass of the boson system. In this paper, we resum these Sudakov logarithms at next-to-next-to-leading logarithmic accuracy and match our predictions to next-to-leading-order (NLO) fixed-order results. We perform the calculation in an automated way, for arbitrary electroweak final states and in the presence of kinematic cuts on the leptons produced in the decays of the electroweak bosons. The resummation is based on a factorization theorem for the cross sections into hard functions, which encode the virtual corrections to the boson production process, and beam functions, which describe the low-pT emissions collinear to the beams. The one-loop hard functions for arbitrary processes are calculated using the MadGraph5_aMC@NLO framework, while the beam functions are process independent. We perform the resummation for a variety of processes, in particular for W+W− pair production followed by leptonic decays of the W bosons.

Nixchen : ein Beitrag zur Psychologie der höheren Tochter

Hans von Kahlenberg

Molecular and cellular basis of bone resorption.

Osteoclast research has an exciting history and a challenging future. More than 3 decades ago, it became evident that bone-resorbing osteoclasts are of hematopoietic origin and are ultimately linked to the "basic multicellular unit," where they team up with the other cell types, including bone-forming osteoblasts. Since 2 decades, we have learned about the signaling pathways controlling genes relevant for osteoclastogenesis and bone resorption. It took another decade until the hypothesized "osteoclast differentiation" factor was discovered and was translated into an approved pharmacologic strategy. Here, the focus is on another molecular target, cathepsin K, a cysteine protease being released by the osteoclast into the resorption compartment. Genetic deletion and pharmacological blocking of cathepsin K reduces bone resorption but with ongoing bone formation. This observation not only holds great promise to become a new pharmacologic strategy, but it also provides new insights into the coordinated work of cells in the "basic multicellular unit" and thus, bridges the history and future of osteoclast research. This article is a short primer on osteoclast biology for readers of the special issue on odanacatib, a cathepsin K inhibitor.

Moses Mendelssohn und die religiösen Gestaltungen des Judentums im 19. Jahrhundert

Max Wiener

Die Civil- und Militair-Verfassung des Deutschen Bundes : enthaltend: Die Bundes-Akte ...

Boberach: Wiedergegeben sind Bundesakte, Wiener Schlußakte, die Ausnahmegesetze von 1819, 1832, 1834 und 1836, die Beschlüsse über ihre Aufhebung 1848 und folgende Dokumente: Vorläufige Geschäfts-Ordnung der Bundes-Versammlung (14. Nov. 1816), Beschluß über die Vertagung (26. Juni 1817), desgl. (20. Sept. 1819), Geschäftsordnung für die Bundestags-Kommissionen (20. April 1819), Austrägal-Ordnung (16. Juni 1817), Verfahren bei Aufstellung von Austrägal-Instanzen (3. Aug. 1820), Exekutions-Ordnung (3. Aug. 1820), desgl. (9. April 1821), Grundzüge der Kriegsverfassung (11. Juni 1822), Allgemeine Kartell-Konvention (10. Febr. 1831), Geldmatrikel (18. Sept. 1843). Beschluß über Unstatthaftigkeit der Einmischung fremder Mächte in die inneren Angelegenheiten des Bundes

Hans Jürgen auf dem Berliner Corso : ein Schwank in plattdeutscher Mundart

Welsch (Projektbearbeiter): Gedicht über den Bauern Hans Jürgen, der nach dem Verkauf seines Roggens in Berlin einen Stadtbummel unternimmt, sich die Börse anschaut, in den "Corso" (Straßenumzug) gerät und dort im Gedränge seines Reiseproviants verlustig geht. Nach dem eher unpolitischen Inhalt zu urteilen stammt das Werkchen nicht aus dem Jahre 1848

Das Oesterreichisch-kaiserliche Bewußtsein

Boberach: Als großer Bundesstaat soll Österreich sich an die Spitze des konstitutionellen Deutschland stellen. Die Aufsätze von Johann von Perthaler in der "Wiener Zeitung" werden kritisiert, die Gesinnung "Österreich über alles" abgelehnt

Neue Nasenstüber für den "Stern"

Boberach: Ein Grazer Schauspieler verteidigt sich gegen politische Anwürfe in der Wiener [wohl eher Grazer] Presse