New finding of Giardia intestinalis (Eukaryote, Metamonad) in Old World archaeological site using immunofluorescence and enzyme-linked immunosorbent assays

In this study, nine organic sediment samples from a medieval archaeological site at Pineuilh, France, were examined for Giardia intestinalis using two commercially available immunological kits [enzyme-linked immuno sorbent and immunofluorescence (IFA) assays]. Both techniques detected G. intestinalis in one sample, dated to 1,000 Anno Domini. This is the first time IFA was successfully used to detect protozoa in Old World archaeological samples. Such immunological techniques offer important perspectives concerning ancient protozoa detection and identification.

Brazilian flora extracts as source of novel antileishmanial and antifungal compounds

Natural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a protozoan parasitic disease found mainly in developing countries, and it has toxic therapies with few alternatives. Fungal infections have been the main cause of death in immunocompromised patients and new drugs are urgently needed. In this work, a total of 16 plant species belonging to 11 families, selected on an ethnopharmacological basis, were analyzed in vitro against Leishmania (L.) chagasi, Leishmania (L.) amazonensis, Candida krusei, and C. parapsilosis. Of these plant species, seven showed antifungal activity against C. krusei, five showed antileishmanial activity against L. chagasi and four against L. amazonensis, among them species of genus Plectranthus. Our findings confirm the traditional therapeutic use of these plants in the treatment of infectious and inflammatory disorders and also offer insights into the isolation of active and novel drug prototypes, especially those used against neglected diseases as Leishmaniasis.

OpenSpires : Opening up Oxford like never before

Oxford University learning technologies group offer a model for effective practice in creating and using OER in research-led teaching environments where academic practice includes dissemination of research which aids/supplements teaching but is not primarily designed as a teaching resource. The University is perceived by many people to be an exclusive institution. It is certainly unique and complex, with characteristics and traditions established over 900 years. An Oxford education offers an exciting combination of privilege and open-mindedness. The role and sustainability of open education technologies in this environment is subtle. Any strategy to effectively encourage the uptake of OERs must be informed by original thinking and reflection about the culture of the organisation. The OpenSpires project was a successful initiative to establish a sustainable set of policies and workflows that would allow departments from across the University of Oxford to regularly publish high quality open content material for global reuse.

Open Educational Resources for Development of University Courses

Open Education Resources are educational materials purposely made available for free use by others. They offer tremendous potential for reducing costs and increasing access to education especially in the developing world. This paper discusses issues of quality, localization, adaptation and integration that need to be addressed in order to make OER adoption a successful strategy.

2010 Horizon Report: Iberoamerican Edition

The series of Horizon Reports is the most tangible outcome of the New Media Consortium's Horizon Project, a qualitative research endeavour launched in 2002 which identifies and describes the emergingtechnologies with the greatest potential to have an impact on teaching, learning, research and creative expression in the global education field. This volume,the 2010 Horizon Report: Iberoamerican Edition, focuses on research in countries of the iberoamerican region (including the whole of Latin America, Spainand Portugal) and in the field of higher education. The 2010 Horizon Report: Iberoamerican Edition is the first to offer this regional contextualization and hasbeen produced by the NMC and the eLearn Center of the Universitat Oberta de Catalunya (UOC).

Managing tobacco use: the neglected cardiovascular disease risk factor.

Cigarette smoking is a major risk factor for cardiovascular disease (CVD) and the leading avoidable cause of death worldwide. Exposure to secondhand smoke (SHS) increases the risk of CVD among non-smokers. Smoking cessation benefits all smokers, regardless of age or amount smoked. The excess risk of CVD is rapidly reversible, and stopping smoking after a myocardial infarction reduces an individual's risk of CVD mortality by 36% over 2 years. Smoking cessation is a key component of primary and secondary CVD prevention strategies, but tobacco use often receives less attention from cardiologists than other risk factors, despite the availability of proven treatments that improve smoking cessation rates. Both psychosocial counselling and pharmacotherapy are effective methods to help smokers quit, but they are most effective when used together. The first-line medications licensed to aid smoking cessation, nicotine replacement therapy, bupropion and varenicline, are effective in and appropriate for patients with CVD. An evidence-based approach for physicians is to routinely ask all patients about smoking status and SHS exposure, advise all smokers to quit and all patients to adopt smoke-free policies for their home and car, and offer all smokers in the office or hospital brief counselling, smoking cessation pharmacotherapy, and referral to local programmes where psychosocial support can be sustained in person or by telephone. Like other chronic diseases, tobacco use requires a long-term management strategy. It deserves to be managed as intensively as other CVD risk factors.

Informe Horizon : edició iberoamericana 2010

La sèrie d'informes Horizon és el resultat més tangible del Projecte Horizon del New Media Consortium, un esforç de recerca qualitativa iniciat el 2002 que identifica i descriu les tecnologies emergents amb més potencial d'impacte en l'ensenyament, l'aprenentatge, la recerca i la expressió creativa en l'àmbit educatiu global. Aquest volum, l'Informe Horizon 2010: Edició Iberoamericana, se centra en la investigació en els països de la regió Iberoamericana (incloent-hi tota Llatinoamèrica, Espanya i Portugal) i en l'àmbit de l'educació superior. L'Informe Horizon 2010: Edició Iberoamericana és el primer que ofereix aquesta contextualització regional i ha estat produït per l'NMC i el eLearn Center de la Universitat Oberta de Catalunya.

Action Research : the first steps to start up a pilot experiment in heritage education

Peer-reviewed

Estat de la qüestió de l'estudi de l'aspecte lèxic : una proposta cognitiva de classficació d'esdeveniments

Peer-reviewed

Mètodes empírics en lingüística cognitiva

Peer-reviewed

Heterologous expression and biochemical characterization of an α1,2-mannosidase encoded by the Candida albicans MNS1 gene

Protein glycosylation pathways, commonly found in fungal pathogens, offer an attractive new area of study for the discovery of antifungal targets. In particular, these post-translational modifications are required for virulence and proper cell wall assembly in Candida albicans, an opportunistic human pathogen. The C. albicans MNS1 gene is predicted to encode a member of the glycosyl hydrolase family 47, with 1,2-mannosidase activity. In order to characterise its activity, we first cloned the C. albicans MNS1 gene into Escherichia coli, then expressed and purified the enzyme. The recombinant Mns1 was capable of converting a Man9GlcNAc2 N-glycan core into Man8GlcNAc2 isomer B, but failed to process a Man5GlcNAc2-Asn N-oligosaccharide. These properties are similar to those displayed by Mns1 purified from C. albicansmembranes and strongly suggest that the enzyme is an ±1,2-mannosidase that is localised to the endoplasmic reticulum and involved in the processing of N-linked mannans. Polyclonal antibodies specifically raised against recombinant Mns1 also immunoreacted with the soluble ±1,2-mannosidases E-I and E-II, indicating that Mns1 could share structural similarities with both soluble enzymes. Due to the high degree of similarity between the members of family 47, it is conceivable that these antibodies may recognise ±1,2-mannosidases in other biological systems as well.

Las comunidades virtuales académicas y científicas españolas : el caso de RedIris

Les comunitats virtuals d'usuaris (o CVU) han esdevingut una plataforma òptima per al treball cooperatiu i la investigació col·laborativa. El present treball descriu el desenvolupament de les CVUs acadèmiques i científiques espanyoles de RedIris a partir de la seva oferta d'eines i serveis d'informació. Els resultats mostren una gran dependència de les llistes de distribució i, en general, una infrautilització de les CVUs i dels seus serveis.

A survey on the enlistment of pharmacists in a hospital battalion of the Swiss Armed Forces

Background: Pharmacists, mainly militiamen, are incorporated in the Swiss Armed Forces, for instance in hospital battalions to supply drugs and medical devices, as well as to coordinate hygiene service. Presently, their duties are only very globally defined. Aims: The objective of this survey was to investigate the tasks that were actually assumed by the military pharmacy of the 2nd Hospital Battalion. Methods: Two types of commitments, offering military and civilian interest's convergence, were considered between 2005 and 2011: (1) army camps for the disabled and (2) operations and supports provided to two nursing homes. While relieving the civil caregiver usually involved with disabled or elderly people, such missions offer indeed the possibility to the army medical service to train its care and logistical processes with real patients, even in the absence of any sanitary crisis or war in the country. Results: Two basis activities have been assumed: (1) centralized supply of drugs and medical devices and (2) coordination of hygiene monitoring and disinfection operations. New tasks were also performed: (3) support to the management of ward-based pharmacies, (4) pillboxes preparation, (5) medication review and (6) selective participation in clinical rounds. The last two were integrated in an interdisciplinary education process. Conclusions: Results shows that, apart from traditional duties, new clinical-oriented activities have been evenly developed and assumed by militia pharmacists. They call thus for a possible renewed definition of the tasks of military hospital pharmacists and of their related military education. A wider study in all hospital battalions is yet mandatory.

La organización de recursos digitales y la oferta de servicios documentales en un entorno virtual de aprendizaje

El creixement d'usuaris potencials i el de l'oferta de serveis per part de la Biblioteca Virtual de l'UOC, va generar un procés de reflexió estratègica per donar resposta a nou escenari de l'organització. El resultat ha estat tres eixos o línies d'actuació que permetin afrontar aquest canvi i creixement: organització dels recursos en una base de dades, el desenvolupament dels serveis "push" i el facilitar l'accés a la biblioteca des de qualsevol entorn i de forma personalitzada a aquest.

Acceso a la Biblioteca de la UOC por medio de la telefonía móvil

La Universitat Oberta de Catalunya, va començar al febrer del 2000, a oferir part dels continguts del Campus Virtual per mitjà del WAP de primera generació.