Colorectal cancer survival in the USA and Europe: a CONCORD high-resolution study.

OBJECTIVES: To assess the extent to which stage at diagnosis and adherence to treatment guidelines may explain the persistent differences in colorectal cancer survival between the USA and Europe. DESIGN: A high-resolution study using detailed clinical data on Dukes' stage, diagnostic procedures, treatment and follow-up, collected directly from medical records by trained abstractors under a single protocol, with standardised quality control and central statistical analysis. SETTING AND PARTICIPANTS: 21 population-based registries in seven US states and nine European countries provided data for random samples comprising 12 523 adults (15-99 years) diagnosed with colorectal cancer during 1996-1998. OUTCOME MEASURES: Logistic regression models were used to compare adherence to 'standard care' in the USA and Europe. Net survival and excess risk of death were estimated with flexible parametric models. RESULTS: The proportion of Dukes' A and B tumours was similar in the USA and Europe, while that of Dukes' C was more frequent in the USA (38% vs 21%) and of Dukes' D more frequent in Europe (22% vs 10%). Resection with curative intent was more frequent in the USA (85% vs 75%). Elderly patients (75-99 years) were 70-90% less likely to receive radiotherapy and chemotherapy. Age-standardised 5-year net survival was similar in the USA (58%) and Northern and Western Europe (54-56%) and lowest in Eastern Europe (42%). The mean excess hazard up to 5 years after diagnosis was highest in Eastern Europe, especially among elderly patients and those with Dukes' D tumours. CONCLUSIONS: The wide differences in colorectal cancer survival between Europe and the USA in the late 1990s are probably attributable to earlier stage and more extensive use of surgery and adjuvant treatment in the USA. Elderly patients with colorectal cancer received surgery, chemotherapy or radiotherapy less often than younger patients, despite evidence that they could also have benefited.

Clinical and molecular delineation of the 17q21.31 microdeletion syndrome

Background: The chromosome 17q21.31 microdeletion syndrome is a novel genomic disorder that has originally been identified using high resolution genome analyses in patients with unexplained mental retardation. Aim: We report the molecular and/or clinical characterisation of 22 individuals with the 17q21.31 microdeletion syndrome. Results: We estimate the prevalence of the syndrome to be 1 in 16 000 and show that it is highly underdiagnosed. Extensive clinical examination reveals that developmental delay, hypotonia, facial dysmorphisms including a long face, a tubular or pear-shaped nose and a bulbous nasal tip, and a friendly/amiable behaviour are the most characteristic features. Other clinically important features include epilepsy, heart defects and kidney/urologic anomalies. Using high resolution oligonucleotide arrays we narrow the 17q21.31 critical region to a 424 kb genomic segment (chr17: 41046729-41470954, hg17) encompassing at least six genes, among which is the gene encoding microtubule associated protein tau (MAPT). Mutation screening of MAPT in 122 individuals with a phenotype suggestive of 17q21.31 deletion carriers, but who do not carry the recurrent deletion, failed to identify any disease associated variants. In five deletion carriers we identify a <500 bp rearrangement hotspot at the proximal breakpoint contained within an L2 LINE motif and show that in every case examined the parent originating the deletion carries a common 900 kb 17q21.31 inversion polymorphism, indicating that this inversion is a necessary factor for deletion to occur (p< 10(25)). Conclusion: Our data establish the 17q21.31 microdeletion syndrome as a clinically and molecularly well recognisable genomic disorder.

Martha Thomas Fitzgerald Papers - Accession 273

The Martha Thomas Fitzgerald Papers consist of biographical data, correspondence, minutes, newspaper clippings, memoranda, reports, and photographs (of particular interest are the many photographs of rural S.C. school houses in the 1920s). The collection pertains to Mrs. Fitzgerald’s work with the South Carolina Department of Education, the South Carolina House of Representatives, and her work with various civic organizations such as the Altrusa Club, the League of Women Voters, the Daughters of American Colonists, United Daughters of the Confederacy (UDC), Business and Professional Women’s Club (BPW), Delta Kappa Gamma, South Carolina Vocational Rehabilitation, and the Salvation Army. There is also information on the Status of Women Commission Council on Aging, agriculture, Queens College, University of South Carolina, Winthrop University, Columbia University, public health, South Carolina history, City of Columbia, South Carolina, and Richland County, South Carolina. Correspondents include Strom Thurmond and three letters from John F. Kennedy when he was senator. Mrs. Fitzgerald was the first woman elected to the South Carolina House of Representatives in a general election.

Bessie Harper Radio Talk Records - Accession 26 - M8 (18)

The Bessie Harper Radio Talk records consist of a draft of a radio talk on "Family Finance" that was broadcast over WIS, Columbia, South Carolina on Monday, January 25th, 1932. Bessie Harper served as chairman of the American Home Department of the South Carolina Federation of Women's Club (SCFWC). The aim of the talk is to educate families how to budget their finances and to plan their expenses which was particularly important when this talk was given in 1932 during the Great Depression. This talk offers a glimpse into families' attempts to cope with the new economic reality of life during the Great Depression.

Christine South Gee Papers - Accession 10

The Christine South Gee Papers include family histories; biographical data; annual reports of home demonstration work in South Carolina (1920-1922) compiled by Mrs. Gee; speeches; magazine articles (1935-1963); newspaper clippings (1934-1968); photographs (1903-1954) and certificates of awards. The collection primarily pertains to Mrs. Gee’s work as South Carolina State Home Demonstration Agent (1918-1923); her role in the formation of the South Carolina Extension Homemakers’ Council (1921), formerly the South Carolina Council of Farm Women; her activities as president of the South Carolina Council for the Common Good (1943-1945); her study of development in programs for adult education and rural women; and her historical interest in South Carolina statesmen and political leaders. Family histories include information on the Puckett, Smith, Martin, Hudgens, McNeese, Rodgers, and Saxon families.

Annual report of the Treasurer of the State of South Dakota for the fiscal year ending ...

Description based on: 1909.

Documents relating to reconstruction,

Issued in numbers as West Virginia university documents relating to reconstruction. Nos. 4-5 and 6-7 pub. as double numbers.

An analysis of diagnostic and rehabilitation efforts - 1976. Analytic study 5/6. Final report.

National Highway Traffic Safety Administration, Office of Driver and Pedestrian Programs, Washington, D.C.

Annual report of the South Dakota Industrial Commissioner.

Report year ends June 30.

Annual Report

Title Varies: 1917-19, First[-Third] Annual Report of the State Highway Commission; 1920-24, Annual Report [etc.]; 1925-Date Annual Report of the South Carolina State Highway Department

North Carolina manual.

Vols. for 1909-33 issued as Publications of the Historical Commission; 1935-39 as Publications of the Legislative Reference Librarian.

The history of a brigade of South Carolinians, known first as "Gregg's" and subsequently as "McGowan's brigade." By J.F.J. Caldwell ... Philadelphia, King & Baird, printers,

Mode of access: Internet.

Bulletins.

Mode of access: Internet.

Cotton yields with recommended and experimental insecticides, 1928-1958 /

"United States Department of Agriculture in cooperation with the South Carolina Agricultural Experiment Station."

William "Bubba" Paris, UM football, 1980

[vs South Carolina]