990 resultados para Sequência de Bases


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O Maciço Granítico Capão Bonito encontra-se associado à evolução da granitogênese neoproterozóica da Província Mantiqueira Central e localiza-se no sudeste do estado de São Paulo, intrusivo em rochas epimetamórficas do Grupo Açungui (Formação Votuverava) e em rochas do Complexo Granítico Três Córregos. As suas rochas afloram junto à borda da Bacia do Paraná e encontram-se parcialmente encobertas por rochas sedimentares do Grupo Itararé e por sedimentos recentes da Bacia do Paraná. Suas rochas estão distribuídas na forma de um corpo alongado e paralelo a direção NE-SW das principais zonas de cisalhamento. È constituído por sienogranitos vermelhos, holo- a leucocráticos com biotita e rara hornblenda, inequigranulares de granulação média a grossa a porfiríticos e isotrópicos a levemente cataclásticos nas zonas marginais. São rochas pertencentes às séries cálcio-alcalinas alto potássio a shoshonítica ou às séries subalcalinas potássicas e caráter metaluminoso a peraluminoso. O magmatismo é compatível com os granitos do tipo A, tardi-orogênicos a anorogênicos de ambiente intraplaca, a partir da fusão de material da crosta inferior com emplacement associado à estrutura transtensiva correlacionada às zonas de cisalhamentos, em um ambiente extensional ao final do evento colisional da Orogênese Ribeira.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Pós-graduação em Ciência da Computação - IBILCE

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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In the context of the studies in the Information Science, the information not just depends on meaning, but the social bows are current of this. The research in development analyse conceptual elements to answer the question about the semiotic foundations of the information mediation processes. This paper aim to know and analyse the semiotic foundations of the information mediation processes in the Information Science context. It presents concepts and reflections regarding the relationship of the information mediation process Charles Peirce's Semiotics, especially, the discussion about the semiotic bases to information mediation process. It discusses the information mediation as a specialization of the communication process, developed, fundamentally, for the human action trying to solve communication and technical problems in sociocultural order.

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A pesquisa foi realizada mediante procedimentos de levantamento e análises bibliográfica e documental, e teve como objetivo analisar as principais alterações sofridas pelo Ensino Médio e Educação Profissional decorrentes da aprovação do ordenamento legal vigente: Constituição Federal de 1988, Lei de Diretrizes e Bases da Educação Nacional – Lei nº. 9.394/96 e Decreto nº. 2.208/97, revogado pelo Decreto nº. 5.154/04. Parte de breve retrospectiva histórica acerca do surgimento e organização de tal escolaridade e, na sequência, examina as principais alterações sofridas pelo Ensino Médio e Educação Profissional trazidas pelo atual conjunto legal, consoante às orientações de reforma e racionalização do Estado, hegemônicas a partir dos anos 1990. Os resultados da pesquisa indicam que, até o momento, não foi possível ainda superar a dualidade histórica que tem prevalecido na etapa final da educação básica. Conclui, que o “Ensino Médio Inovador” pode ser um caminho viável para integração Ensino Médio e Educação Profissional.

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A recent study showed that tetrahydrofuran (THF), a widely used solvent, is carcinogenic in experimental animals. Despite its carcinogenic activity, there is a paucity of information regarding cellular toxicity, biomolecular damage, and genotoxicity induced by THF. We describe here the structural characterization of adducts produced by the reaction of oxidized THF with 2'-deoxyguanosine (dGuo-THF 1 and dGuo-THF 2), 2'-deoxyadenosine (dAdo-THF), and 2'-deoxycytidine (dCyd-THF). Adducts were isolated from in vitro reactions by reverse-phase HPLC and fully characterized on the basis of spectroscopic measurements. The stable derivatives obtained by the reduction of adducts with NaBH4 ( the case of dGuo-THF 1, dCyd-THF, and dAdo-THF) and the stable adduct dGuo-THF 2 were used as standards for optimization of chromatographic separations for adduct detection in DNA through HPLC/ESI/MSMS. Using this methodology, we successfully detected the four adducts in calf thymus DNA reacted with oxidized THF. The present study also provides evidence that rat liver microsomal monooxigenases oxidize THF to the reactive electrophilic compounds that are able to damage the DNA molecule, as indicated by a significant increase in adduct dGuo-THF 1 level when NADPH was added to the THF/ microsomes/dGuo incubation mixtures. Our data point to DNA-THF adducts as possible contributing factors to the toxicological effects of THF exposure.

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The present paper introduces a new model of fuzzy neuron, one which increases the computational power of the artificial neuron, turning it also into a symbolic processing device. This model proposes the synapsis to be symbolically and numerically defined, by means of the assignment of tokens to the presynaptic and postsynaptic neurons. The matching or concatenation compatibility between these tokens is used to decided about the possible connections among neurons of a given net. The strength of the compatible synapsis is made dependent on the amount of the available presynaptic and post synaptic tokens. The symbolic and numeric processing capacity of the new fuzzy neuron is used here to build a neural net (JARGON) to disclose the existing knowledge in natural language data bases such as medical files, set of interviews, and reports about engineering operations.

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The study area is located in the southern portion of Rio Itapicuru Greenstone Belt, Bahia, where were found rocks that belongs to the Canto Sequence, that comprises felsics and intermediary rocks, beyond metasediments. The studied maps and drill holes help to recognized stratigraphy column that was divided in three mains domains, from the base to the top: andesitics to felsics lavas domain, carbonaceous and metasedimentary domains. The data obtained in mapping and petrography analysis allows classify the area in three deformational phases, Dn, Dn+1, Dn+2. The metamorphism recognized according to the mineralogical associations permitted to classify a progressive regional metamorphism (lower to medium greenchist facies) till biotite zone, falling until chlorite zone due to retrometamorphism. The auriferous mineralizations are mainly related to hydrothermal veins included in the different lithologies, mainly in carbonaceous schists

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A espécie Prochilodus lineatus, considerada um migrador por excelência, possui intensa ocorrência durante a migração reprodutiva. São peixes de elevado valor econômico e a sua adaptação em cativeiro os tornam altamente interessantes para desenvolvimento de programas de piscicultura. O monitoramento regular das variações genéticas nos estoques é importante em programas de conservação, evitando o declínio da variabilidade genética, essencial para a conservação das espécies. No entanto, os poucos dados moleculares populacionais para Prochilodus lineatus justificam a presente proposta. Nesse sentido, tivemos como objetivo caracterizar a variabilidade genética e estabelecer as relações filogeográficas entre 6 populações de P. lineatus das bacias dos rios Paraguai (2 do rio Paraguai e 3 do rio Cuiabá, MT) e Paraná (1 do rio Mogi-Guaçu, SP), num total de 34 indivíduos. Outros 16 indivíduos dos rios: da Prata, Uruguai, Paraná, Bermejo, Paraguai, Amazonas e Madeira, cujas sequências foram obtidas do National Center for Biotechnology Information (Genbank), foram analisados, totalizando assim, 50 indivíduos. Como grupo externo foi utilizado Salminus brasiliensis. O estudo foi realizado através das análises das sequências do gene mitocondrial ATPase 8/6. O interesse do uso de um gene mitocondrial está na vasta literatura que esse possui em análises filogenéticas e na confiança que existe nos dados gerados de tais análises. O gene citado foi completamente sequenciado (842pb), as análises filogenéticas foram conduzidas pelos métodos “Neighbor Joining (NJ)”, “Minimum Evolution (ME)” e “Máxima Parcimônia (MP)”, com 1000 réplicas de bootstrap no programa MEGA 5.0. Para análises filogeográficas as sequências foram analisadas no programa TCS e no programa Arlequin. Os resultados auxiliarão em uma melhor compreensão da história evolutiva, migração... (Resumo completo, clicar acesso eletrônico abaixo)

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Acupuncture is a technique belonging to traditional Chinese medicine that has existed for over 3000 years. It consists of stimuli by pressure, needling, heat and electrical stimulation of the skin at specific points to restore the health of patients. This technique has been increasingly incorporated into the West and therefore the research explaining its various mechanisms become very important to translate these ancient skills. This article is a literature review summarizing the basic concepts, historical and local, anti-inflammatory and neurological effects acupuncture in the body

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The study area of the Guarda-Mor target (Israelândia-GO) contextualizes the terrains of the estaern portion of the Arenópolis Magmatic Arc, more accurately, the Neoproterozoic associations inserted in the field of the Jaupaci volcano-sedimentary sequence. The mapped area is located in the central-western of Goiás state. The presente paper has as main objective to characterize the structural, petrographic and litogeochemistry of the target rocks beyond to compare these factors with the Mina Bacilândia rocks (Fazenda Nova-GO) in order to assess the genetic similarity of volcano-sedimentary units and deposits associated. The Guarda-Mor target is represented by the Jaupaci metavolcanic rocks sequence presenting bimodal volcanism. This sequence consists in metafelsic rocks like sericite/muscovite quartz schist, phyllite and metarriolites and/or metariodacites with calc-alkaline geochemical signature and metamafic rocks with tholeiitic character formed by actinolite - chlorite schist and chlorite - quartz schist. Besides the package of supracrustal rocks also can be observed the occurrence of a local intrusion syn- to late - tectonic named Granito Subvulcânico. In the study area beyond the marked volcanism also seen an event of crustal melting granitogênese evidenced by the presence of 2 granites at the east and the west of the map, Granito Israelândia and Granito Iporá respectively. Structural analysis both at the macro and micro have identified 3 deformation phases. The types of rock on the region record features in the metamorphic facies top and down. These features were subdivided into 3 metamorphic areas: the east and West areas show thermal metamorphism due to intrusion of adjacente granites while the central domain displays features of regional metamorphism. Gold mineralization of the Guarda –Mor deposit target suggests a possible structural control beyond pronounced the hydrothermal alteration. The mineralization may also be...

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Volunteering is seen as a form of citizen participation enabling to involve, mobilize, engage and articulate people and institutions around issues of collective interest. Both for the volunteer and for the community involved, voluntary action can promote learning, new experiences and interaction with people previously unknown, as well as create opportunities for professional and personal growth. (CENTRO DE VOLUNTARIADO DE SÃO PAULO, 2012). This work starts from a survey conducted in 2006 by Carvalho, who detected the interest of members of the campus community Guaratinguetá UNESP in performing volunteer work. Its objective is to continue the work mentioned and think of ways to support volunteering in the Guaratinguetá Engineering College, mainly through the creation of connections between stakeholders (individuals and institutions). For this, focused Volunteer Centers and their functional models. Such a center could be the ideal facilitator of relationships between volunteer candidates that integrate FEG / UNESP community and institutions interested in the collaboration of these people. The work highlighted the benefits that voluntary action can bring to those involved in it, and the role that a Volunteer Center at UNESP Guaratinguetá may play, in the promotion and expansion of social activities already undertaken. The study also indicates the need for a validation of the proposals presented here and later detailing way of acting of the Centre in its institutional placement and maintenance costs

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At a time when people turn increasingly to technological innovations and virtual networks, a closer interaction with the environment can provide sensitizing experiences. One tool that facilitates this approach is the interpretative trail: its use in a Unit of Conservation (UC) allows more contact between the visitor and the nature elements. This research aimed to propose the establishment of an interpretative trail at the State Florest “Edmundo Navarro de Andrade” (FEENA) in Rio Claro (SP) with theoretical bases from Waldorf Pedagogy. The proposed trail is destined for students with 07-14 years-old, a period that the awareness is more accurate in a person, according to Waldorf tenets. On the path of the trail, we propose some educational activities at the points of interpretation: storytelling about environment; “photograph” the place with a drawing; create a song with sounds produced by the body and by nature elements; blindfold guide and a circle of people to share experiences. The activities aim to provide in the student a close and harmonious contact with oneself, with other people and with the natural world, and also serve as a support for programs of public use and environmental education at UC. The environmental awareness process in the context of FEENA - which has a significant landscape valuation - develops through the sensibilities of exterior and interior world. And also develops with the creation if images, thoughts, feelings and interdependencies relationships. Therefore, the ecologic education allows changes and formation of values and sensitive attitudes to students about the environment

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In the last years Brazil has achieved a leading position in worldwide cattle breeding. This country is consolidating the practice of an intensive and technical level cattle breeding, due to greater emphasis on reproductive efficiency and genetic improvement. The attention given to reproductive efficiency became to enhance the genetic improvement process, by exploiting the full reproductive potential of the animals. The biotechniques applied to reproduction arised to expand the reproductive potential for greater economic return. Are the most important reproductive biotechniques the FTAI and in vivo and in vitro embryo production for embryo transfer. Different hormonal treatments are consolidating to interfere with normal physiology in order to achieve the desired goals. The FTAI works to increase the reproductive rates of cattle through pre-booked artificial insemination in all the females in reproduction, without the need for estrous detection. The in vivo and in vitro embryo production aims to distribute the genetics of males and females genetically improved by transferring their embryos to genetically inferior females. Superovulation treatments designed to prevent the mechanism of dominance, which results in many follicles ovulating simultaneously for in vivo embryo production. To the in vitro embryo production, the technique of ovarian puncture guided by transvaginal ultrasound allows to aspirate a number of quality oocytes. The application of biotech is based on knowledge of the female and ovarian reproductive physiology and knowledge of their acting in different breeds and environments.