996 resultados para Prices increase


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The objective of this study was to evaluate the production cost and profitability of the second season corn crop in the Medio Paranapanema region, São Paulo State Brazil, under two technological levels (middle and high technology), crop 2008/2009, and compare the results with the 2006/2007 agricultural year. Effective and total operational cost as well as five profitability indicators were used. It was concluded that the high technology production cost for corn crop (direct seedling, sowing during the recommended period, use of simple hybrid seed, application of side-dressing fertilization, and treatment of seeds with different insecticides) was superior to the middle technology production cost (direct seedling, sowing after the recommended time, use of double hybrid seed, and no side-dressing fertilization). However, the average cost was inferior (US$ 8.5), due to a higher yield (4 t). The high technology corn crop was profitable (gross income and profitability index of 14% and 12%, respectively). For the middle technology crop, profitability indexes pointed out that the cropping system needs to be reevaluated by technicians and research institutions, regarding the adequate technical recommendations. Profitability indexes decreased considerably in both cropping systems. It was verified that, in relation to the 2006/2007 harvest period, the total operational cost increased for both technologies, mainly because of the increase of supplies prices.

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Background & Aims Patients infected with hepatitis C virus (HCV) genotype 1, body weight <85 kg, and high baseline viral load respond poorly to standard doses of pegylated interferon (peginterferon) and ribavirin. We evaluated intensified therapy with peginterferon alfa-2a plus ribavirin. Methods This double-blind randomized trial included HCV genotype 1-infected outpatients from hepatology clinics with body weight <85 kg and HCV RNA titer <400,000 IU/mL. Patients were randomized to 180 μg/wk peginterferon alfa-2a for 48 weeks plus 1200 mg/day ribavirin (standard of care) (group A, n = 191) or 1400/1600 mg/day ribavirin (group B, n = 189). Additional groups included 360 μg/wk peginterferon alfa-2a for 12 weeks then 180 μg/wk peginterferon alfa-2a for 36 weeks plus 1200 mg/day ribavirin (group C, n = 382) or 1400/1600 mg/day ribavirin (group D, n = 383). Follow-up lasted 24 weeks after treatment. Results Sustained virologic response rates (HCV RNA level <15 IU/mL at end of follow-up) in groups A, B, C, and D were 38%, 43%, 44%, and 41%, respectively. There were no significant differences among the 4 groups or between pooled peginterferon alfa-2a regimens (A + B vs C + D: odds ratio [OR], 1.08; 95% confidence interval [CI], 0.831.39; P = .584) or pooled ribavirin regimens (A + C vs B + D: OR, 1.00; 95% CI, 0.791.28; P = .974). Conclusions In patients infected with HCV genotype 1 who are difficult to treat (high viral load, body weight <85 kg), a 12-week induction regimen of peginterferon alfa-2a and/or higher-dose ribavirin is not more effective than the standard regimen. © 2010 AGA Institute.

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