What the Law Requires: Accessible Multi-family Housing in Iowa, 2003

Booklet produced by the Iowa Civil Rights Commission for individuals who own, design, build, or develop multi-family housing.

A-1 Monthly Public Assistance Statistical Report Family Investment Program, May 2003

Monthly Public Assistance Statistical Report Family Investment Program

A-1 Monthly Public Assistance Statistical Report Family Investment Program, July 2004

Monthly Public Assistance Statistical Report Family Investment Program

A-1 Monthly Public Assistance Statistical Report Family Investment Program, August, 2004

Monthly Public Assistance Statistical Report Family Investment Program

Identification of potential small molecule binding pockets on Rho family GTPases

Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activity is associated with many human diseases including cancer. Extensive high-resolution structures (.100) and recent mutagenesis studies have laid the foundation for the design of new structure-based chemotherapeutic strategies. Although the inhibition of Rho signaling with drug-like compounds is an active area of current research, very little attention has been devoted to directly inhibiting Rho by targeting potential allosteric non-nucleotide binding sites. By avoiding the nucleotide binding site, compounds may minimize the potential for undesirable off-target interactions with other ubiquitous GTP and ATP binding proteins. Here we describe the application of molecular dynamics simulations, principal component analysis, sequence conservation analysis, and ensemble small-molecule fragment mapping to provide an extensive mapping of potential small-molecule binding pockets on Rho family members. Characterized sites include novel pockets in the vicinity of the conformationaly responsive switch regions as well as distal sites that appear to be related to the conformations of the nucleotide binding region. Furthermore the use of accelerated molecular dynamics simulation, an advanced sampling method that extends the accessible time-scale of conventional simulations, is found to enhance the characterization of novel binding sites when conformational changes are important for the protein mechanism.

Villisca Municipal Power Plant, Independent Auditor's Reports Financial Statements and Supplemental Information Schedule of Findings, December 31, 2003

Other Audit Report - Utilities

A-1 Monthly Public Assistance Statistical Report Family Investment Program, September 2004

Monthly Public Assistance Statistical Report Family Investment Program

A-1 Monthly Public Assistance Statistical Report Family Investment Program, October 2004

Monthly Public Assistance Statistical Report Family Investment Program

A-1 Monthly Public Assistance Statistical Report Family Investment Program, November 2004

Monthly Public Assistance Statistical Report Family Investment Program

A-1 Monthly Public Assistance Statistical Report Family Investment Program, December 2004

A-1 Monthly Public Assistance Statistical Report Family Investment Program

A-1 Monthly Public Assistance Statistical Report Family Investment Program, January 2005

A1-Monthly Public Assistance Statistical Report Family Investment Program

Famílies immigrades i escoles: dinàmiques de relació a Catalunya

A Catalunya els discursos acadèmics i de l'administració han anat evolucionant fins que s'han imposat aquells que apunten a que la relació entre l'escola, la família i l'entorn és clau per l'èxit escolar de l'alumnat i el bon funcionament del sistema educatiu. Malgrat aquesta evolució, en la pràctica el canvi és lent i, sovint, complicat, donat que apareixen resistències en les dues institucions, família i escola, degut a que fins avui sempre s'ha mantingut una relació marcada pel desequilibri de poder. El nostre treball teòric i, sobretot, empíric s'ha centrat en la relació entre la família immigrada i l'escola a Catalunya. Com es presentarà, la creació del que hem anomenat dinàmiques positives de relació i comunicació en els centres escolars es troba condicionada per les actituds i els comportaments dels equips directius, els professionals i les famílies, tot i que també l'espai físic en que es donen aquestes relacions és important. Respecte a la organització del centre hem destacat el papel de l'equip directiu. Diferenciant una models de gestió observem aquells més facilitadors de la relació i la comunicació amb i entre les famílies i aquells més desincentivadors. Això sí, sempre s'ha de tenir en compte les actituds dels docents i de les famílies que són múltiples i complexes.

Power Comic Reader : Lector de comics para plataforma iOS

Lector de comics para plataforma iOS para dispositivos iPad.