Surdez induzida pelo trauma acústico

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

The crisis in Iraq and the twists and turns of Turkish Middle East policy. OSW Commentary No. 142, 29.07.2014

The spectacular offensive by Islamic radicals in Iraq this June has led the country to the verge of collapse, and is another scene of the deep crisis in the Middle East, in which Turkey is entangled. The immediate consequence of this is a severe crisis of prestige after the kidnapping by terrorists of Turkish diplomats and Ankara’s inability to resolve the situation; in the long term consequences include escalation of the Kurdish problem, and a further increase in threats to the security of Turkey itself as well as the fundamental principles of its foreign policy. Both Ankara’s options and its political will to actively respond to the crisis are extremely limited. Yet again in recent years, the current crisis, the broader situation in the Middle East, and finally the position of Turkey in the region elude unambiguous assessments and forecasts – these are prevented by the scale and growth of the reappraisals and tensions in the region. The only undoubted fact is that Turkey is strategically and irreversibly entangled in the Middle East’s problems, which are an important factor affecting the transformation of the state which the ruling AKP is implementing; and in the near future, this state of affairs will only deepen.

The radical Islamic militants of Central Asia. OSW Report, November 2013

Radical Islamic militants from Central Asia have ceased to be a local phenomenon. The organisations created by those groups (the Islamic Movement of Uzbekistan and the Islamic Jihad Union) engage in propaganda, recruitment, fundraising and terrorist operations in states distant from their traditional area of interest, such as European Union countries, South Asia and the United States. Their ranks contain not only Central Asian Islamists, but also those from other countries, such as Russia, Pakistan, Germany, France, the United Kingdom, China, Turkey and even Myanmar. These organisations’ current activities and forms are multidimensional and complicated, characterised by combat versatility, structural amorphism, operational mobility and simultaneous operations in different fields and theatres. As a result of the universalization of Islamic terrorism, these organisations have been intensifying contacts with other international Islamic terrorist organisations based in Waziristan (mainly al-Qaida, Taliban and the Haqqani Network). A specific system of mutual cooperation has developed between them, involving the specialisation of various terrorist organisations in particular aspects of terrorist activity. The IMU and IJU specialise in the recruitment and training of Islamic radicals from around the world, and have thus become a kind of ‘jihad academy’.

A constitution for Erdoğan. Consequences of the political conflict in Turkey. OSW COMMENTARY No. 213, 2016-06-01

Since mid-2015 Turkey has been affected by a deep internal crisis, caused by rising political polarisation, increased levels of terrorist threat (posed by the Kurds and Islamic radicals) and the revived conflict with the Kurdistan Workers’ Party (PKK). As a consequence of this crisis, over 350,000 residents of south-eastern Turkey have been forced to leave their homes. At the same time, due to the migration crisis and despite mutual distrust in relations between Turkey and the EU, cooperation between Ankara and Brussels has been intensifying. Turkey’s ongoing destabilisation does not challenge the status of the ruling Justice and Development Party (AKP), which is de facto controlled by President Recep Tayyip Erdoğan; paradoxically, it strengthens the party. The internal crisis which the authorities have been deliberately fuelling is an element of a plan to rubber-stamp political change by introducing a presidential system of government. This is happening amid a thorough reconstruction of the socio-political order which has been underway for over a decade. In the upcoming months it is expected to result in the constitution being changed and, as a consequence, the institutionalisation of Erdoğan’s autocratic rule.

O licopeno como composto bioativo do tomate

A crescente preocupação com o bem-estar físico e a saúde tem vindo a refletir-se na forma como escolhemos os alimentos presentes na nossa alimentação. Todos nós somos consumidores mais informados e escolhemos cada vez mais alimentos saudáveis. Por outro lado, algumas doenças como os acidentes vasculares cerebrais, o cancro e a aterosclerose podem de alguma forma ser minimizados através da ingestão de alguns compostos denominados compostos bioativos ou funcionais. A presente dissertação tem como objetivo efetuar uma revisão na literatura dos estudos publicados sobre os efeitos do licopeno na saúde humana na prevenção de doenças, desempenhando assim o papel de composto bioativo do tomate. Os radicais livres atuam no organismo, podendo provocar lesões celulares que podem estar na base do desenvolvimento de alguns cancros e doenças crónicas. Conhecido como um dos melhores supressores de radicais livres, o licopeno é um dos antioxidantes mais poderosos, sendo o carotenóide predominante nos tomates, mas a sua biodisponibilidade aumenta em produtos de tomate processado, razão pela qual será o fruto abordado na presente dissertação. Fez-se uma abordagem do licopeno como composto bioativo do tomate, da sua respetiva química, da sua biodisponibilidade, do papel fundamental dos carotenoides na nossa alimentação e do seu papel na prevenção de várias doenças. Por fim é apresentada uma breve perspetiva nutricional sobre a adição de licopeno a alguns alimentos como forma de aproveitar os resíduos que a indústria do tomate origina, tornando-os nutricionalmente mais ricos.

Influência da localização geográfica de produção nas propriedades de mirtilos 'Vaccinium Corymbosum L.' cv Bluecrop

Os antioxidantes na dieta podem ter um papel importante na prevenção de algumas doenças crónicas em seres humanos resultantes da oxidação de lípidos e outros componentes celulares por radicais livres. Os mirtilos (Vaccinium sp.) são considerados, de entre os frutos frescos, uma das melhores fontes de antioxidantes. Neste trabalho foram estudados mirtilos Nothern Highbush, da cultivar Bluecrop colhidos no estado de maturação comercial em 5 localizações diferentes: Bouças -Sever do Vouga, Estarreja, Queirã – Vouzela, Oliveira do Hospital e Vila Verde. Foram avaliadas as características físico-químicas (ºbrix, acidez, humidade, calibre, firmeza, elasticidade e parâmetros colorimétricos) dos frutos. Para a determinação da composição fenólica e a atividade antioxidante os mirtilos foram submetidos a extrações sucessivas, com metanol (2x) e depois 2 vezes com uma solução aquosa de acetona (40% v/v), durante 1 h, com o auxílio de um banho de ultrassons. Os extratos obtidos foram utilizados para a determinação da composição fenólica (compostos fenólicos totais, antocianinas e taninos) e da capacidade antioxidante (utilizando os métodos ABTS, DPPH e FRAP). Foi ainda avaliada a influência da conservação durante 6 meses a -20ºC no teor de compostos fenólicos e capacidade antioxidante dos frutos. Pelos resultados obtidos, nos parâmetros de textura avaliados a amostra BBO revelou maior firmeza e elasticidade, e na avaliação da cor a amostra BES apresentou uma tonalidade azul mais acentuada. Os mirtilos provenientes de Estarreja eram os mais ricos em compostos fenólicos totais, em antocianinas e taninos, e que também apresentavam maior atividade antioxidante. O armazenamento durante 6 meses a -20ºC, originou diferenças significativas nas antocianinas e na atividade antioxidante. Em geral as amostras apresentavam diferenças significativas tanto nas suas propriedades físico-químicas, como na composição fenólica e na atividade antioxidante.

Antioxidant Properties of Bee Products of Plant- Origin Part 2. Propolis and Pollen

Over the last years, the hive products such as propolis and pollen have been highlighted due to their potential health benefits, including antioxidant abilities that have been correlated with their content in phenolic compounds. Regardless of the several factors that may affect propolis and pollen antioxidant activity, these products have been shown to possess, either through the use of in vitro or in vivo models, important features concerning the modulation of cellular oxidative stress caused by environmental factors (e.g. UV-light), metals, pesticides and other xenobiotics. This modulatory effect focus not only on the capture of radicals that these elements might eventually generate, but also by the activation of cellular antioxidant mechanisms such as enzymatic antioxidants or by modifying gene expression patterns. Although the mechanisms behind these responses are not fully known, it has been showed that caffeic acid phenethyl ester, pinocembrin and chrisin are some of the compounds responsible for some of these responses. Taking into account the gathered results, propolis and pollen can be viewed as potential agents in the re-stabilization of cellular oxidative imbalance and in the prevention of oxidative stress related diseases.

Imperium in imperio /

Wright, L.H. Amer. fiction, 1876-1900,

S-E-R-P.

Mode of access: Internet.

Memoirs of Henry Hunt, Esq. /

Mode of access: Internet.

Print, Publicity and Radicalism in the 1790s : The Laurel of Liberty /

Jon Mee explores the popular democratic movement that emerged in the London of the 1790s in response to the French Revolution. Central to the movement’s achievement was the creation of an idea of ‘the people’ brought into being through print and publicity. Radical clubs rose and fell in the face of the hostile attentions of government. They were sustained by a faith in the press as a form of ‘print magic,’ but confidence in the liberating potential of the printing press was interwoven with hard-headed deliberations over how best to animate and represent the people. Ideas of disinterested rational debate were thrown into the mix with coruscating satire, rousing songs, and republican toasts. Print personality became a vital interface between readers and print exploited by the cast of radicals returned to history in vivid detail by Print, Publicity, and Popular Radicalism.

Molecular analysis of the pathway for the synthesis of thiol tripeptides in the model legume Lotus japonicus

The thiol tripeptides, glutathione (GSH) and homoglutathione (hGSH), perform multiple roles in legumes, including protection against toxicity of free radicals and heavy metals. The three genes involved in the synthesis of GSH and hGSH in the model legume, Lotus japonicus, have been fully characterized and appear to be present as single copies in the genome. The gamma-glutamylcysteine synthetase (gammaecs) gene was mapped on the long arm of chromosome 4 (70.0 centimorgans [cM]) and consists of 15 exons, whereas the glutathione synthetase (gshs) and homoglutathione synthetase (hgshs) genes were mapped on the long arm of chromosome 1 (81.3 cM) and found to be arranged in tandem, with a separation of approximately 8 kb. Both genes consist of 12 exons of exactly the same size (except exon 1, which is similar). Two types of transcripts were detected for the gshs gene, which putatively encode proteins localized in the plastids and cytosol. Promoter regions contain cis-acting regulatory elements that may be involved in the plant's response to light, hormones, and stress. Determination of transcript levels, enzyme activities, and thiol contents in nodules, roots, and leaves revealed that gammaecs and hgshs are expressed in all three plant organs, whereas gshs is significantly functional only in nodules. This strongly suggests an important role of GSH in the rhizobia-legume symbiosis.

Discoloration and mineralization of Reactive Red HE-3B by heterogeneous photo-Fenton reaction

Discoloration and mineralization of Reactive Red HE-3B were studied by using a laponite clay-based Fe nanocomposite (Fe-Lap-RD) as a heterogeneous catalyst in the presence of H2O2 and UV light. Our experimental results clearly indicate that Fe-Lap-RD mainly consists of Fe2O3 (meghemite) and Fe2Si4O10(OH)2 (iron silicate hydroxide) which have tetragonal and monoclinic structures, respectively, and has a high specific surface area (472m(2) / g) as well as a high total pore volume (0.547 cm(3)/g). It was observed that discoloration of HE-3B undergoes a much faster kinetics than mineralization of HE-3B. It was also found that initial HE-3B concentration, H2O2 concentration, UV light wavelength and power, and Fe-Lap-RD catalyst loading are the four main factors that can significantly influence the mineralization of HE-3B. At optimal conditions, complete discoloration of 100 mg/L HE-3B can be achieved in 30 min and the total organic carbon removal ratio can attain 76% in 120 min, illustrating that Fe-Lap-RD has a high photo-catalytic activity in the photo-assisted discoloration and mineralization of HE-3B in the presence of UV light (254nm) and H2O2. (C) 2003 Elsevier Science Ltd. All rights reserved.

Alpha-lipoic acid does not acutely affect resistance and conduit artery function or oxidative stress in healthy men

Aims Alpha-lipoic acid (ALA) is a thiol compound with antioxidant properties used in the treatment of diabetic polyneuropathy. ALA may also improve arterial function, but there have been scant human trials examining this notion. This project aimed to investigate the effects of oral and intra-arterial ALA on changes in systemic and regional haemodynamics, respectively. Methods In study 1, 16 healthy older men aged 58 +/- 7 years (mean +/- SD) received 600 mg of ALA or placebo, on two occasions 1 week apart, in a randomized cross-over design. Repeated measures of peripheral and central haemodynamics were then obtained for 90 min. Central blood pressure and indices of arterial stiffness [augmentation index (AIx) and estimated aortic pulse wave velocity] were recorded non-invasively using pulse wave analysis. Blood samples obtained pre- and post-treatments were analysed for erythrocyte antioxidant enzyme activity, plasma nitrite and malondialdehyde. In study 2 the effects of incremental cumulative doses (0.5, 1.0, 1.5 and 2.0 mg ml(-1) min(-1)) of intra-arterial ALA on forearm blood flow (FBF) were assessed in eight healthy subjects (aged 31 +/- 5 years) by conventional venous occlusion plethysmography. Results There were no significant changes on any of the central or peripheral haemodynamic measures after either oral or direct arterial administration of ALA. Plasma ALA was detected after oral supplementation (95% confidence intervals 463, 761 ng ml(-1)), but did not alter cellular or plasma measures of oxidative stress. Conclusions Neither oral nor intra-arterial ALA had any effect on regional and systemic haemodynamics or measures of oxidative stress in healthy men.