Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10(-8) to P = 10(-190)). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.

Seguiment temporal de l'àrea marina protegida de les Illes Medes. Informe anual. Any 2001

Aquesta Memòria constitueix la onzena remesa, corresponent als resultats obtinguts en 2001, dels treballs de seguiment que, des del 1990, ve efectuant l'equip del Departament d'Ecologia en la Reserva Marina de les Illes Medes per encàrrec del Departament d'Agricultura, Ramaderia i Pesca (de 1990 a 1998) i del Departament de Medi Ambient (des de 1999) en compliment dels imperatius que marca la Llei 19/1990, de 10 de desembre del Parlament de Catalunya. L'objectiu de dita Llei és la conservació de la fauna i flora dels fons marins de les illes Medes, i el seu Pla d'Usos estableix l'obligatorietat de realitzar estudis científics de monitorització que guiïn i avalin l'adequació de la gestió.

Cens de la població nidificant del gavià de potes grogues (Larus Cachinnans) a l'arxipèlag de les Illes Medes durant l'any 2001

Podeu consultar l'Informe complet a: http://hdl.handle.net/2445/23672

Cens de la colònia d'Ardèids de les Illes Medes a l'any 2001

Podeu consultar l'Informe complet a: http://hdl.handle.net/2445/23672

Seguimiento de la pradera de Posidonia Oceanica de les Islas Medes. Ejercicio 2001

Podeu consultar l'Informe complet a: http://hdl.handle.net/2445/23672

Seguiment temporal de la garota comuna Paracentrotus Lividus en les Illes Medes. Exercici 2001

Podeu consultar l'Informe complet a: http://hdl.handle.net/2445/23672

Seguiment temporal de la gorgònia Paramuricea Clavata de les Illes Medes. Exercici 2001

Podeu consultar l'Informe complet a: http://hdl.handle.net/2445/23672

Avaluació de la població de corall Corallium Rubrum de les Illes Medes. Exercici 2001

Podeu consultar l'Informe complet a: http://hdl.handle.net/2445/23672

Avaluació de la població de llagostes (Palinurus elephas) de les Illes Medes. Exercici 2001

Podeu consultar l'Informe complet a: http://hdl.handle.net/2445/23672

Seguiment de la població de meros (Epinephelus Marginatus) i d'altres espècies vulnerables de les Illes Medes i la costa veïna parcialment protegida (1991-2001)

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Contingut de matèria orgànica al sòl segons els usos forestals a les Gavarres (Girona)

El següent article és un estudi sobre el contingut de matèria orgànica als sòls del massís de les Gavarres tenint en compte dos aspectes, el primer segons sigui la litologia i segon el tipus d'ús del sòl. Per això s'ha dividit el massís entre els dos grans components litològics: granits i pissarres. A la vegada s'han estudiat els usos del sòl més representatius d'aquesta muntanya: la sureda estassada, la sureda abandonada, les plantacions de pins, les plantacions d'eucaliptus i un bosc mixt de pins i suros. Els resultats mostren que el contingut de matèria orgànica pel que fa a la litologia és molt més alt als sòls sobre pissarres. Quant als usos del sòl, el major contingut correspon a les suredes i el menor a les plantacions d'eucaliptus.

Self reported physical activity, public health, and perceived environment: results from a comparative European study

The focus of physical activity promotion is moving from methods for increasing health enhancing physical activity on the individual level to higher level strategies including environmental and policy approaches. Scientific inquiry, traditionally related to individual-based strategies, requires adaptation and refinement when environmental and policy changes become more relevant. The objective of this study is to investigate the significance for behaviour and health of community-based environments that encourage physical activity. DESIGN AND SETTING The article presents data and results from a cross sectional comparative survey of the general population in six European countries (Belgium, Finland, Germany (East and West), Netherlands, Spain, Switzerland). Specifically, the relation between perceived community-based opportunities for physical activity, self reported physical activity, and self rated health status is investigated. PARTICIPANTS Representative samples of general populations (adults 18 years or older). Overall response rate: 53.5%. Sample sizes realised: Belgium: n=389; Finland: n=400; Germany (East): n = 913; Germany (West): n=489; Netherlands: n=366; Spain: n=380; Switzerland: n=406. MAIN RESULTS Analyses show that best opportunities are reported by people who are lightly to moderately physically active. People's self rated health is moderately, but significantly associated with both perceived opportunities, and physical activity itself. These predictors interact in that especially for women, the health impact of physical activity is more pronounced in case of good opportunities. CONCLUSIONS The paper shows the potential of opportunities within residential and community environments with regard to physical activity, both for behaviour and health. Opportunities may enable the population, especially women, to develop an active lifestyle, and thus improve their health. Future studies with objective indicators for physical activity related environments should test the findings that are based on perceptions.

A pioneering epidemiological study investigating the incidence of squamous cell carcinoma of tongue in a Portuguese population

Objective: The purpose of this study was to investigate the incidence of squamous cell carcinoma (SCC) of the anterior two thirds of the tongue in a population living in central and southern Portugal, all treated at Instituto Português de Oncologia de Lisboa, Francisco Gentil (IPOLFG). Study Design: This study was a retrospective review of all patients who had a histopathological diagnosis of SCC of the anterior two thirds of the tongue and had been treated in the Head and Neck Surgery Unit at the IPOLFG (Lisbon, Portugal), between 1st January 2001 and 31st December 2009. The risk factors evaluated were: gender; age; alcohol consumption; tobacco use; prosthesis use and the carcinoma site. Results: Of the 424 cases analysed, 71% were men. Mean age of occurrence was in 5th decade for males and the 6th decade for females, and the border of the tongue was the most common location. Alcohol consumption and tobacco had a lower impact in women, being the most common aetiological factors in the male population. No significant association was observed between patients and the use of a prosthesis. Conclusions: In spite of the consumption of aohol and tobacco starting to decline in certain parts of the world, our findings showed both factors still have a significant impact in male population. Further research should be done to determine aetiological factors in females.

Determinants of methicillin-susceptible Staphylococcus aureus native bone and joint infection treatment failure: a retrospective cohort study.

BACKGROUND: Although methicillin-susceptible Staphylococcus aureus (MSSA) native bone and joint infection (BJI) constitutes the more frequent clinical entity of BJI, prognostic studies mostly focused on methicillin-resistant S. aureus prosthetic joint infection. We aimed to assess the determinants of native MSSA BJI outcomes. METHODS: Retrospective cohort study (2001-2011) of patients admitted in a reference hospital centre for native MSSA BJI. Treatment failure determinants were assessed using Kaplan-Meier curves and binary logistic regression. RESULTS: Sixty-six patients (42 males [63.6%]; median age 61.2 years; interquartile range [IQR] 45.9-71.9) presented an acute (n = 38; 57.6%) or chronic (n = 28; 42.4%) native MSSA arthritis (n = 15; 22.7%), osteomyelitis (n = 19; 28.8%) or spondylodiscitis (n = 32; 48.5%), considered as "difficult-to-treat" in 61 cases (92.4%). All received a prolonged (27.1 weeks; IQR, 16.9-36.1) combined antimicrobial therapy, after surgical management in 37 cases (56.1%). Sixteen treatment failures (24.2%) were observed during a median follow-up period of 63.3 weeks (IQR, 44.7-103.1), including 13 persisting infections, 1 relapse after treatment disruption, and 2 super-infections. Independent determinants of treatment failure were the existence of a sinus tract (odds ratio [OR], 5.300; 95% confidence interval [CI], 1.166-24.103) and a prolonged delay to infectious disease specialist referral (OR, 1.134; 95% CI 1.013-1.271). CONCLUSIONS: The important treatment failure rate pinpointed the difficulty of cure encountered in complicated native MSSA BJI. An early infectious disease specialist referral is essential, especially in debilitated patients or in presence of sinus tract.

Oral tongue squamous cell carcinoma (OTSCC): alcohol and tobacco consumption versus non-consumption. A study in a Portuguese population

There has been an increase in the incidence of carcinoma of the tongue, particularly among alcohol and tobacco non-users. However, the number of studies that would allow a better understanding of etiological factors and clinical features, particularly in the Portuguese population, is very limited. This study was based on patients with squamous cell carcinoma of the anterior two thirds of the tongue that were treated at the Department of Head and Neck Surgery of the ¿Instituto Portugues de Oncologia de Lisboa - Francisco Gentil" IPOLFG) in Lisbon, Portugal, between January 1, 2001 and December 31, 2009. The patients were divided in alcohol and tobacco users and non-users in order to evaluate the differences between these 2 groups based on gender, age, tumor location, denture use, and tumor size, metastasis and stage. Of the 354 cases, 208 were users and 146 were non-users. The main location in both groups was the lateral border of the tongue. Denture use showed no significant effect in both study groups. It was possible to conclude that patients who did not drink or smoke were older and presented with smaller tumor size, lower incidence of ganglion metastasis and lower tumor stage compared with alcohol and tobacco users.