2015, declarado año europeo del desarrollo

Boletín semanal para profesionales sanitarios de la Secretaría General de Calidad, Innovación y Salud Pública de la Consejería de Igualdad, Salud y Políticas Sociales

Aveux baillés à Jean de Saillant par ses vassaux, en 1484 et années suivantes.

Acquis le 9 mars 1836 d'Armans-Alexis Monteil pour le prix de 200 francs, parmi 52 volumes mss. y compris 3 rouleaux; cf. B.n.F., département des Manuscrits, registre des acquisitions 1833-1848, n° 1875 "16 terriers"

Leçons sur plusieurs points de droit canon, par "Stephanus Troches, Petrus de Stagno, Johannes Caldrini, Paulus de Liazzariis, Symo de Brosano et Wilhelmus de Henburg".

Acquis le 11 mars 1846 de M. Roibin, pour le prix de 30 francs; cf. B.n.F., département des Manuscrits, registre des acquisitions 1833-1848, n° 4067; — a appartenu à l'abbaye du Parc près Louvain (dioc. de Liège puis de Malines); cf. Delisle, Cab. des mss., II, 390; — cote "K theca VIII" (contreplat sup.)

Documents relatifs à la canonisation de la reine Jeanne de Valois.

Acquis le 11 décembre 1830 de M. de Montmerqué de Paris par échange; cf. B.n.F., département des Manuscrits, registre des acquisitions 1828-1833, n° 78 "il a donné les procès verbaux et autres pièces originales, relatifs à la canonisation de la reine Jeanne de France de la branche de Valois fille de Louis XI et femme de Louis XII, contre quinze signatures anciennes"; — note autographe "(...) ces pièces ont été préservées de la destruction par le soussigné. Il prie messieurs les bibliothéquaires et conservateurs de la Bibliothèque du roi d'en agréer l'offre et de les réunir aux manuscrits qui concernent l'histoire de France. A Paris le 11 décembre 1830. Montmerqué, conseiller à la C. royale de Paris" (1)

Management of bleeding following major trauma: an updated European guideline.

INTRODUCTION Evidence-based recommendations are needed to guide the acute management of the bleeding trauma patient, which when implemented may improve patient outcomes. METHODS The multidisciplinary Task Force for Advanced Bleeding Care in Trauma was formed in 2005 with the aim of developing a guideline for the management of bleeding following severe injury. This document presents an updated version of the guideline published by the group in 2007. Recommendations were formulated using a nominal group process, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) hierarchy of evidence and based on a systematic review of published literature. RESULTS Key changes encompassed in this version of the guideline include new recommendations on coagulation support and monitoring and the appropriate use of local haemostatic measures, tourniquets, calcium and desmopressin in the bleeding trauma patient. The remaining recommendations have been reevaluated and graded based on literature published since the last edition of the guideline. Consideration was also given to changes in clinical practice that have taken place during this time period as a result of both new evidence and changes in the general availability of relevant agents and technologies. CONCLUSIONS This guideline provides an evidence-based multidisciplinary approach to the management of critically injured bleeding trauma patients.

Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4.

Cell adhesion to the extracellular matrix proteins occurs through interactions with integrins that bind to Arg-Gly-Asp (RGD) tripeptides, and syndecan-4, which recognizes the heparin-binding domain of other proteins. Both receptors trigger signaling pathways, including those that activate RhoGTPases such as RhoA and Rac1. This sequence of events modulates cell adhesion to the ECM and cell migration. Using a neuron-astrocyte model, we have reported that the neuronal protein Thy-1 engages αVβ3 integrin and syndecan-4 to induce RhoA activation and strong astrocyte adhesion to their underlying substrate. Thus, because cell-cell interactions and strong cell attachment to the matrix are considered antagonistic to cell migration, we hypothesized that Thy-1 stimulation of astrocytes should preclude cell migration. Here, we studied the effect of Thy-1 expressing neurons on astrocyte polarization and migration using a wound-healing assay and immunofluorescence analysis. Signaling molecules involved were studied by affinity precipitation, western blotting and the usage of specific antibodies. Intriguingly, Thy-1 interaction with its two receptors was found to increase astrocyte polarization and migration. The latter events required interactions of these receptors with both the RGD-like sequence and the heparin-binding domain of Thy-1. Additionally, prolonged Thy-1-receptor interactions inhibited RhoA activation while activating FAK, PI3K and Rac1. Therefore, sustained engagement of integrin and syndecan-4 with the neuronal surface protein Thy-1 induces astrocyte migration. Interestingly we identify here, a cell-cell interaction that despite initially inducing strong cell attachment, favors cell migration upon persistent stimulation by engaging the same signaling receptors and molecules as those utilized by the extracellular matrix proteins to stimulate cell movement.