Benchmarking therapeutic drug monitoring software: A systematic evaluation of available computer tools

Introduction: Therapeutic drug monitoring (TDM) aims at optimizing treatment by individualizing dosage regimen based on measurement of blood concentrations. Maintaining concentrations within a target range requires pharmacokinetic and clinical capabilities. Bayesian calculation represents a gold standard in TDM approach but requires computing assistance. In the last decades computer programs have been developed to assist clinicians in this assignment. The aim of this benchmarking was to assess and compare computer tools designed to support TDM clinical activities.¦Method: Literature and Internet search was performed to identify software. All programs were tested on common personal computer. Each program was scored against a standardized grid covering pharmacokinetic relevance, user-friendliness, computing aspects, interfacing, and storage. A weighting factor was applied to each criterion of the grid to consider its relative importance. To assess the robustness of the software, six representative clinical vignettes were also processed through all of them.¦Results: 12 software tools were identified, tested and ranked. It represents a comprehensive review of the available software's characteristics. Numbers of drugs handled vary widely and 8 programs offer the ability to the user to add its own drug model. 10 computer programs are able to compute Bayesian dosage adaptation based on a blood concentration (a posteriori adjustment) while 9 are also able to suggest a priori dosage regimen (prior to any blood concentration measurement), based on individual patient covariates, such as age, gender, weight. Among those applying Bayesian analysis, one uses the non-parametric approach. The top 2 software emerging from this benchmark are MwPharm and TCIWorks. Other programs evaluated have also a good potential but are less sophisticated (e.g. in terms of storage or report generation) or less user-friendly.¦Conclusion: Whereas 2 integrated programs are at the top of the ranked listed, such complex tools would possibly not fit all institutions, and each software tool must be regarded with respect to individual needs of hospitals or clinicians. Interest in computing tool to support therapeutic monitoring is still growing. Although developers put efforts into it the last years, there is still room for improvement, especially in terms of institutional information system interfacing, user-friendliness, capacity of data storage and report generation.

Benchmarking therapeutic drug monitoring software: A systematic evaluation of available computer tools

Objectives: Therapeutic drug monitoring (TDM) aims at optimizing treatment by individualizing dosage regimen based on blood concentrations measurement. Maintaining concentrations within a target range requires pharmacokinetic (PK) and clinical capabilities. Bayesian calculation represents a gold standard in TDM approach but requires computing assistance. The aim of this benchmarking was to assess and compare computer tools designed to support TDM clinical activities.¦Methods: Literature and Internet were searched to identify software. Each program was scored against a standardized grid covering pharmacokinetic relevance, user-friendliness, computing aspects, interfacing, and storage. A weighting factor was applied to each criterion of the grid to consider its relative importance. To assess the robustness of the software, six representative clinical vignettes were also processed through all of them.¦Results: 12 software tools were identified, tested and ranked. It represents a comprehensive review of the available software characteristics. Numbers of drugs handled vary from 2 to more than 180, and integration of different population types is available for some programs. Nevertheless, 8 programs offer the ability to add new drug models based on population PK data. 10 computer tools incorporate Bayesian computation to predict dosage regimen (individual parameters are calculated based on population PK models). All of them are able to compute Bayesian a posteriori dosage adaptation based on a blood concentration while 9 are also able to suggest a priori dosage regimen, only based on individual patient covariates. Among those applying Bayesian analysis, MM-USC*PACK uses a non-parametric approach. The top 2 programs emerging from this benchmark are MwPharm and TCIWorks. Others programs evaluated have also a good potential but are less sophisticated or less user-friendly.¦Conclusions: Whereas 2 software packages are ranked at the top of the list, such complex tools would possibly not fit all institutions, and each program must be regarded with respect to individual needs of hospitals or clinicians. Programs should be easy and fast for routine activities, including for non-experienced users. Although interest in TDM tools is growing and efforts were put into it in the last years, there is still room for improvement, especially in terms of institutional information system interfacing, user-friendliness, capability of data storage and automated report generation.

A Computer Based Information System for County Equipment Cost Records, Final Report, HR-173, 1975

This appendix is divided into three sections. The first section contains abstracts of each of the eight computer programs in the system, instructions for keypunching the three input documents, and computer operating instructions pertaining to each program. The second section contains system flowcharts for the entire system as well as program flowcharts for each program. The last section contains PL/l program listings of each program.

A Randomized Controlled Trial of the Effectiveness of Computer-Assisted Cognitive Remediation (CACR) in Adolescents with Psychosis or at High Risk of Psychosis.

Background: Computer assisted cognitive remediation (CACR) was demonstrated to be efficient in improving cognitive deficits in adults with psychosis. However, scarce studies explored the outcome of CACR in adolescents with psychosis or at high risk. Aims: To investigate the effectiveness of a computer-assisted cognitive remediation (CACR) program in adolescents with psychosis or at high risk. Method: Intention to treat analyses included 32 adolescents who participated in a blinded 8-week randomized controlled trial of CACR treatment compared to computer games (CG). Cognitive abilities, symptoms and psychosocial functioning were assessed at baseline and posttreatment. Results: Improvement in visuospatial abilities was significantly greater in the CACR group than in CG. Other cognitive functions, psychotic symptoms and psychosocial functioning improved significantly, but at similar rates, in the two groups. Conclusion: CACR can be successfully administered in this population; it proved to be effective over and above CG for the most intensively trained cognitive ability.

quantiNemo: an individual-based program to simulate quantitative traits with explicit genetic architecture in a dynamic metapopulation.

quantiNemo is an individual-based, genetically explicit stochastic simulation program. It was developed to investigate the effects of selection, mutation, recombination and drift on quantitative traits with varying architectures in structured populations connected by migration and located in a heterogeneous habitat. quantiNemo is highly flexible at various levels: population, selection, trait(s) architecture, genetic map for QTL and/or markers, environment, demography, mating system, etc. quantiNemo is coded in C++ using an object-oriented approach and runs on any computer platform. Availability: Executables for several platforms, user's manual, and source code are freely available under the GNU General Public License at http://www2.unil.ch/popgen/softwares/quantinemo.

Adult Education and Literacy Program, FY2014, December 11, 2014

Adult Education has a rich history in Iowa of providing services that assist adults in improving their skills, achieving their educational goals, and transitioning to further education or employment. Instruction is designed for adults functioning at the lowest levels of basic skills and English language instruction to advanced levels of learning.

Developing an Effective Construction Training Program for American Supervisors with Hispanic Craft Workers, 2005

In the construction industry, Hispanics have the highest rate of fatal work injuries among the racial/ethnic groups, and productivity in the field is limited by the language barrier between Hispanic workers and their supervisors and the level of education of many Hispanic craft workers. This research developed a training program designed to facilitate the integration process between American supervisors and Hispanic craft workers in a practical and cost-effective way, thus improving productivity and lowering fatality rates. The Iowa State University research team conducted a survey of 38 American supervisors, representing 14 Iowa construction companies. Survey results confirm that communication is the main problem experienced by American supervisors in the job site. Many American supervisors also use or depend on a link-person (an individual who interprets tasks to the rest of the Hispanic crew) to communicate to the Hispanic crew members. Research findings show that language differences affect productivity and workplace safety in the construction industry. Additionally, the educational levels of Hispanic workers indicate that they may not have the literacy skills necessary to understand training materials. This research developed two training courses designed to expand the Spanish communication skills of American supervisors. The research team modified the English-as-a-second-language course developed in Phase I into the Spanish as a Second Language (SSL) Survival Course. A series of technical training courses were also developed, titled Concrete Pavement Construction Basics (CPCB), that cover general practices in concrete pavement construction. They are much shorter and more specialized than the SSL course. The CPCB courses provide American supervisors simple and practical communication tools on a variety of topics to choose from according to their specific needs.

Protection of publicly distributed software components

The nature of client-server architecture implies that some modules are delivered to customers. These publicly distributed commercial software components are under risk, because users (and simultaneously potential malefactors) have physical access to some components of the distributed system. The problem becomes even worse if interpreted programming languages are used for creation of client side modules. The language Java, which was designed to be compiled into platform independent byte-code is not an exception and runs the additional risk. Along with advantages like verifying the code before execution (to ensure that program does not produce some illegal operations)Java has some disadvantages. On a stage of byte-code a java program still contains comments, line numbers and some other instructions, which can be used for reverse-engineering. This Master's thesis focuses on protection of Java code based client-server applications. I present a mixture of methods to protect software from tortious acts. Then I shall realize all the theoretical assumptions in a practice and examine their efficiency in examples of Java code. One of the criteria's to evaluate the system is that my product is used for specialized area of interactive television.

Inventario de fichas de operaciones estadísticas

Se ha propuesto al IBESTAT un proyecto global basado en la implantación de un sistema de gestión mediante un desarrollo a medida para el tratamiento, la gestión, el control y la difusión de las actividades estadísticas que se llevan a cabo en la comunidad autónoma por parte de los diferentes organismos públicos, enmarcadas en el programa anual y en el plan estadístico que oficializan dichos datos, basado en las reuniones mantenidas y en la información a la que ha tenido acceso. El alcance contempla tanto la definición de la arquitectura necesaria de la plataforma, como el desarrollo y la puesta en producción. El proyecto permitirá al IBESTAT disponer de una aplicación web desarrollada mediante una tecnología integrada con el resto de la informática del gobierno de las Islas Baleares y en especial con lo referente a la nueva estrategia de desarrollo de servicios web y de aplicación telemática enmarcada en la Ley 11/2007 de acceso de los ciudadanos a la administración digital por medios telemáticos.

Thick XML client and technology of its construction

Nykyään kolmeen kerrokseen perustuvat client-server –sovellukset ovat suuri kinnostuskohde sekä niiden kehittäjille etta käyttäjille. Tietotekniikan nopean kehityksen ansiosta näillä sovelluksilla on monipuolinen käyttö teollisuuden eri alueilla. Tällä hetkellä on olemassa paljon työkaluja client-server –sovellusten kehittämiseen, jotka myös tyydyttävät asiakkaiden asettamia vaatimuksia. Nämä työkalut eivät kuitenkaan mahdollista joustavaa toimintaa graafisen käyttöliittyman kanssa. Tämä diplomityö käsittelee client-server –sovellusten kehittamistä XML –kielen avulla. Tämä lähestymistapa mahdollistaa client-server –sovellusten rakentamista niin, että niiden graafinen käyttöliittymä ja ulkonäkö olisivat helposti muokattavissa ilman ohjelman ytimen uudelleenkääntämistä. Diplomityö koostuu kahdesta ostasta: teoreettisesta ja käytännöllisestä. Teoreettinen osa antaa yleisen tiedon client-server –arkkitehtuurista ja kuvailee ohjelmistotekniikan pääkohdat. Käytannöllinen osa esittää tulokset, client-server –sovellusten kehittämisteknologian kehittämislähestymistavan XML: ää käyttäen ja tuloksiin johtavat usecase– ja sekvenssidiagrammit. Käytännöllinen osa myos sisältää esimerkit toteutetuista XML-struktuureista, jotka kuvaavat client –sovellusten kuvaruutukaavakkeiden esintymisen ja serverikyselykaaviot.

Porting a Java library to different platforms

Viime aikoina matkapuhelimet ovat alkaneet tukea Javaa matkapuhelinsovellusten ohjelmointikielenä. Javan perusajatus on, että kerran käännetty sovellus voidaan suorittaa useilla laitealustoilla ilman uudelleenkääntämisen tarvetta. Jotta sovellukset voisivat toimia uudella alustalla, niiden käyttämät kirjastot tulee siirtää uudelle alustalle. Tämä diplomityö tutkii tämänkaltaiseen siirtoprojektiin liittyviä asioita. Diplomityön aikana käyttöliittymäkirjasto siirrettiin olemassa olleelta alustalta kahdelle uudelle alustalle. Toinen uusista alustoista oli vanhan alustan uusi versio, ja toinen oli kokonaan uusi alusta. Ohjelmiston siirtämistä helpottaa jos alkuperäinen ohjelmisto on suunniteltu siirrettävyyttä silmälläpitäen. Varsinaiset ohjelmaan tehtävät muutokset ovat tällöin helppoja tehdä. Hyvälaatuisen lopputuloksen saaminen vaatii kuitenkin aina että ohjelmisto myös testataan huolellisesti.

Simulation Supported Robot Programming using XML

The main objective of this master's thesis is to study robot programming using simulation software, and also how to embed the simulation software into company's own robot controlling software. The further goal is to study a new communication interface to the assembly line's components -more precisely how to connect the robot cell into this new communication system. Conveyor lines are already available where the conveyors use the new communication standard. The robot cell is not yet capable of communicating with to other devices using the new communication protocols. The main problem among robot manufacturers is that they all have their own communication systems and programming languages. There has not been any common programming language to program all the different robot manufacturers robots, until the RRS (Realistic Robot Simulation) standards were developed. The RRS - II makes it possible to create the robot programs in the simulation software and it gives a common user interface for different robot manufacturers robots. This thesis will present the RRS - II standard and the robot manufacturers situation for the RRS - II support. Thesis presents how the simulation software can be embedded into company's own robot controlling software and also how the robot cell can be connected to the CAMX (Computer Aided Manufacturing using XML) communication system.

Forecasting a language shift based on cellular automata

Language extinction as a consequence of language shifts is a widespread social phenomenon that affects several million people all over the world today. An important task for social sciences research should therefore be to gain an understanding of language shifts, especially as a way of forecasting the extinction or survival of threatened languages, i.e., determining whether or not the subordinate language will survive in communities with a dominant and a subordinate language. In general, modeling is usually a very difficult task in the social sciences, particularly when it comes to forecasting the values of variables. However, the cellular automata theory can help us overcome this traditional difficulty. The purpose of this article is to investigate language shifts in the speech behavior of individuals using the methodology of the cellular automata theory. The findings on the dynamics of social impacts in the field of social psychology and the empirical data from language surveys on the use of Catalan in Valencia allowed us to define a cellular automaton and carry out a set of simulations using that automaton. The simulation results highlighted the key factors in the progression or reversal of a language shift and the use of these factors allowed us to forecast the future of a threatened language in a bilingual community.

JAVA APIS FOR BLUETOOTH WIRELESS TECHNOLOGY

Bluetooth™ Teknologia - Bluetooth Wireless Technology - on lyhyen kantaman langaton kommunikointiteknologia. Vaikka se onkin ensisijaisesti suunniteltu kaapelin korvaajaksi laitteiden omaan toimintaan liittyvässä liikenteessä, voidaan sitä myös käyttää alustana monen käyttäjien peleissä ja muissa vastaavissa sovelluksissa. Tassa diplomityössä esitellään Bluetooth teknologia sovellusohjelmoijan näkökulmasta. Työssä esitellään teollisuuskonsortion määrittelemä Java-ohjelmointirajapinta Bluetooth teknologiaan. Tämän rajapinnan avulla voidaan kehittää kannettavia sovelluksia jotka kommunikoivat Bluetooth yhteyden yli. Rajapinta pohjautuu "Java™ 2 Microedition" alustaan ja on siten toteutettavissa myös pienissä laitteissa kuten matkapuhelimissa. Työssä esitellään lyhyesti rajapinnan keskeiset osat sekä annetaan esimerkki rajapinnan käytöstä. Työn konstruktiivisessa osassa rajapinnan keskeiset on toteutettu kahdelle eri alustalle: Sambian™ ja Microsoft® Windows® käyttöjärjestelmille. Talla tavalla on saatu arvokasta tietoa siitä, miten kyseinen rajapinta tulisi toteuttaa ja myös siitä miten sovellukset sitä käyttäisivät. Keskeiset suunnitteluratkaisut ja saadut kokemukset on raportoitu työn kirjallisessa osassa. Vaikka työn konstruktiivinen osuus onkin luonteeltaan esitutkimus eikä tähdännyt tuotteeseen, on tuloksena syntynyttä rajapintaa tarkoitus käyttää useassa Nokian sisäisessä tutkimus-ja kehityshankkeessa.

Understanding Optical Trapping Phenomena: a Simulation for Undergraduates

Optical trapping is an attractive and multidisciplinary topic that has become the center of attention to a large number of researchers. Moreover, it is a suitable subject for advanced students that requires a knowledge of a wide range of topics. As a result, it has been incorporated into some syllabuses of both undergraduate and graduate programs. In this paper, basic concepts in laser trapping theory are reviewed. To provide a better understanding of the underlying concepts for students, a Java application for simulating the behavior of a dielectric particle trapped in a highly focused beam has been developed. The program illustrates a wide range of theoretical results and features, such as the calculation of the force exerted by a beam in the Mie and Rayleigh regimes or the calibration of the trap stiffness. Some examples that are ready to be used in the classroom or in the computer lab are also supplied.