Aquifer recharge in Moura region (South Portugal)

Dissertação de mest., Recursos Hídricos, Faculdade de Ciências e Tecnologia, Univ. do Algarve, 2011

Land deed between Alex Outlaw and Calvin Spencer

This document is a land deed between Alex Outlaw and Calvin Spencer.

Calvin Spencer division of estate and estate settlement

This document establishes the division of Calvin Spencer's estate among his heirs as well as the settlement of his estate among his wife and heirs.

Composers' Workshop, February 25, 1999

Concert program for Composers' Workshop, February 25, 1999

Rare Gems: Uncommon Chamber Music January 18, 2001

Concert Program for Rare Gems: Uncommon Chamber Music January 18, 2001

Projecto "Darma". Instalação e performance de luzes e sombras

Trabalho de projecto apresentado para cumprimento dos requisitos necessários à obtenção do grau Mestre em Ciências da Comunicação na especialização de Comunicação e Artes

Impact of genetic SLC28 transporter and ITPA variants on ribavirin 21 serum level, hemoglobin drop and therapeutic response in patients with HCV infection

Background: T reatment o f chronic hepatitis C i s evolving, a nd direct acting antivirals ( DAAs) are now a dded to p egylated interferon-α ( Peg- INF-α) and ribavirin (RBV) for the treatment o f hepatitis C v irus ( HCV) genotype 1 infection. DAAs c ause d ifferent side effects and can even worsen RBV induced hemolytic anemia. T herefore, identifying host genetic d eterminants of R BV bioavailability and therapeutic e fficacy will remain crucial for individualized treatment. Recent d ata showed associations between R BV induced h emolytic anemia and genetic polymorphisms o f concentrative nucleoside transporters s uch as C NT3 (SLC28A3) and i nosine t riphosphatase (ITPA). T o analyze t he association of genetic variants of SLC28 transporters and ITPA with RBV induced hemolytic anemia and treatment o utcome. Methods: I n our study, 173 patients f rom t he S wiss Hepatitis C C ohort Study and 2 2 patients from Swiss Association for the Study of the Liver study 24 (61% HCV g enotype 1, 3 9% genotypes 2 o r 3) were analyzed for SLC28A2 single nucleotide p olymorphism (SNP) rs11854484, SLC28A3 rs56350726 and SLC28A3 rs10868138 as well as ITPA SNPs rs1127354 and rs7270101. RBV serum levels during treatment were measured in 49 patients. Results: SLC28A2 r s11854484 genotype TT was associated with significantly higher dosage- and body weight-adjusted RBV levels as compared to genotypes TC and CC (p=0.04 and p=0.02 at weeks 4 and 8, respectively). ITPA SNPs rs1127354 and rs7270101 were associated with h emolytic a nemia both in genotype as w ell as i n allelic a nalyses. SLC28A3 rs56350726 genotype TT (vs. AT/AA, RR=2.1; 95% CI 1.1-4.1) as well as the T allele (vs. A; RR=1.8, 95% CI 1.1-3.2) were associated with increased SVR rates. The combined analysis of overall ITPA activity and SLC28 v ariants together revealed n o significant a dditive effects on either treatment-related anemia or SVR. Conclusions: T he newly identified association between RBV serum levels a nd SLC28A2 rs11854484 genotype as well as the replicated association of ITPA and SLC28A3 g enetic p olymorphisms w ith RBV induced hemolytic anemia and treatment r esponse underpin the need for further studies on host genetic d eterminants of R BV bioavailability and therapeutic e fficacy f or individualized treatment of chronic hepatitis C.

IFN stimulated gene expression in the liver is a better predictor of treatment response in chronic hepatitis c than the IL28b (IFN lambda 3) genotype

Background: Therapy of chronic hepatitis C (CHC) with pegIFNa/ribavirin achieves sustained virologic response (SVR) in ~55%. Pre-activation of the endogenous interferon system in the liver is associated non-response (NR). Recently, genome-wide association studies described associations of allelic variants near the IL28B (IFNλ3) gene with treatment response and with spontaneous clearance of the virus. We investigated if the IL28B genotype determines the constitutive expression of IFN stimulated genes (ISGs) in the liver of patients with CHC. Methods: We genotyped 93 patients with CHC for 3 IL28B single nucleotide polymorphisms (SNPs, rs12979860, rs8099917, rs12980275), extracted RNA from their liver biopsies and quantified the expression of IL28B and of 8 previously identified classifier genes which discriminate between SVR and NR (IFI44L, RSAD2, ISG15, IFI22, LAMP3, OAS3, LGALS3BP and HTATIP2). Decision tree ensembles in the form of a random forest classifier were used to calculate the relative predictive power of these different variables in a multivariate analysis. Results: The minor IL28B allele (bad risk for treatment response) was significantly associated with increased expression of ISGs, and, unexpectedly, with decreased expression of IL28B. Stratification of the patients into SVR and NR revealed that ISG expression was conditionally independent from the IL28B genotype, i.e. there was an increased expression of ISGs in NR compared to SVR irrespective of the IL28B genotype. The random forest feature score (RFFS) identified IFI27 (RFFS = 2.93), RSAD2 (1.88) and HTATIP2 (1.50) expression and the HCV genotype (1.62) as the strongest predictors of treatment response. ROC curves of the IL28B SNPs showed an AUC of 0.66 with an error rate (ERR) of 0.38. A classifier with the 3 best classifying genes showed an excellent test performance with an AUC of 0.94 and ERR of 0.15. The addition of IL28B genotype information did not improve the predictive power of the 3-gene classifier. Conclusions: IL28B genotype and hepatic ISG expression are conditionally independent predictors of treatment response in CHC. There is no direct link between altered IFNλ3 expression and pre-activation of the endogenous system in the liver. Hepatic ISG expression is by far the better predictor for treatment response than IL28B genotype.

1969-70 Hockey Team

1969-71 Brock Generals Hockey team. Members from left to right - Back row: Tom Kearney (Trainer), Al Kellogg (Coach), John Hull, Craig Morrison, Gregg Law, Frank Mucci, Dale Andreas, Eric Stevens, Serge Girrard, John Clarey, Wayne Kenyon, Reg Egilsson, Dusty Papke, Randy Oiling (Manager). Front row: Ron Powel, Barry Hopkins, Bruce Wormald, Miller Hicks, Fred Carter, Mike Nicholson, Dick Overholt, Chris Shott. Missing: John O'Brien, Barry Elliot.

1970-71 Hockey Team

1970-71 Brock Generals Hockey team. The members from left to right - Back row: Tom Kearney (trainer), Joel Finlay, Tony Grey, Gregg Carrigan, Craig Morrison, Pat Moroney, Rick Charron, Jim Swain, Bill Fuller, Barry Hopkins, Mike McNiven, Rick Sullivan, Ed Barszcz, Phil McCann, Randy Oiling (Manager), Al Kellogg (Coach). Front row: Wayne Butt, Ron Powell, Tim Goodman, Pat McCann, Arkell Farr, Dave Perrin, Gregg Law. Missing: Jeff Della Vedova.

Women's Volleyball Team (1972-73)

Back Row: Marsia Antolak (Manager), Marcia Liddycoat, Wendy Krasovev, Violette Lavigne, Elanie Keith, Jean Nairn, Kathy Kirkpatrickm Pat Hueston (Coach) Front Row: Beth Craig, Lee Bartley, Judt Trowbridge, Jeanie Dulewicz, Miriam Ganton

Ed Davis Award

Ed Davis, former hockey coach, with Glen Craig, recipient of the Ed Davis Award for being the team's most valuable player.

New Brock Centre

The Brock centre was later renamed Alphie's Trough after Alfred, the horse given to General Brock by Sir James Craig.