Post-partum anoestrus in tropical beef cattle: A systems approach combining gene expression and genome-wide association results

The length of the post-partum anoestrous interval affects reproductive efficiency in many tropical beef cattle herds. In this study, results from genome-wide association studies (Experiment 1: GWAS) and gene expression (Experiment 2: microarray) were combined in a systems approach to reveal genetic markers, genes and pathways underlying the physiology of post-partum anoestrus in tropically adapted cattle. The microarray study measured the expression of 13,964 genes in the hypothalamus of Brahman cows. A total of 366 genes were differentially expressed (DE) in the post-partum period, when acyclic cows were compared to cows that had resumed ovarian cycles. Associated markers (P < 0.05) from a high density GWAS pointed to 2829 genes that were associated with post-partum anoestrous interval (PPAI) in two populations of beef cattle: Brahman and Tropical composite. Together the experiments provided evidence for 63 genes that are likely to influence the resumption of ovulation post-partum in tropically adapted beef cattle. Functional annotation analysis revealed that some of the 63 genes have known roles in hormonal activity, energy balance and neuronal synapse plasticity. Polymorphisms within candidate genes identified by this systems approach could have biological significance in post-partum anoestrus and help select Zebu (Bos indicus) influenced cattle with genetic potential for shorter post-partum anoestrus. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.

RNS derivation of N-point disk amplitudes from the revisited S-matrix approach

Recently, in [7] we proposed a revisited S-matrix approach to efficiently find the bosonic terms of the open superstring low energy effective lagrangian (OSLEEL). This approach allows to compute the alpha'(N) terms of the OSLEEL using open superstring n-point amplitudes in which n is considerably lower than (N + 2) (which is the order of the required amplitude to obtain those alpha'(N) terms by means of the conventional S-matrix approach). In this work we use our revisited S-matrix approach to examine the structure of the scattering amplitudes, arriving at a closed form for them. This is a RNS derivation of the formula first found by Mafra, Schlotterer and Stieberger [21], using the pure spinor formalism. We have succeeded doing this for the 5, 6 and 7-point amplitudes. In order to achieve these results we have done a careful analysis of the kinematical structure of the amplitudes, finding as a by-product a purely kinematical derivation of the BCJ relations (for N = 4, 5, 6 and 7). Also, following the spirit of the revisited S-matrix approach, we have found the alpha' expansions for these amplitudes up to alpha'(6) order in some cases, by only using the well known open superstring 4-point amplitude, cyclic symmetry and tree level unitarity: we have not needed to compute any numerical series or any integral involving polylogarithms, at any moment. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).

Protonation Pattern, Tautomerism, Conformerism, and Physicochemical Analysis in New Crystal Forms of the Antibiotic Doxycycline

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Therapeutic Delivery of miR-200c Enhances Radiosensitivity in Lung Cancer

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

ORIGIN AND EARLY DIVERSIFICATION OF THE PHYLUM CNIDARIA VERRILL: MAJOR DEVELOPMENTS IN THE ANALYSIS OF THE TAXON'S PROTEROZOIC-CAMBRIAN HISTORY

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The Role of Lipotoxicity in Smoke Cardiomyopathy

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Construções gramaticais e questões estilísticas no livro Piccoli equivoci senza importanza, de Antonio Tabucchi

The translation project of some short stories of the book Piccoli equivoci senza importanza, written by the Italian writer Antonio Tabucchi, was performed during the academic years. This thesis target is to analyze grammatical and stylistic issues of the short stories; to achieve this goal, parts of the original texts and their respective translations were used. The grammar section approaches important aspects as idioms, false cognates and different verb regencies between Portuguese and Italian. The stylistic part focuses on Tabucchi´s choices regarding the narrator, focalization, types of speech and interior monologues in his texts; these options characterize the Italian writer´s style and make his stories plots intense. As a conclusion it can be noticed that this work is relevant to give a forward step in the Italian literature studies field, because it contributes to an important author style study and provides the analysis of which choices compound the text and the effects they cause

Uma viagem entre Tabucchi, Pessoa e Pirandello: proposta de tradução de Il signor Pirandello è desiderato al telefono, de Antonio Tabucchi

The present monography consists in a translation of the play “Il signor Pirandello è desiderato al telefono”, by the Italian writer Antonio Tabucchi. This translation is still unpublished in Brazil. The introduction emphasizes the relevance of this translation in the Brazilian literary context, due to its goal of dissemination of a piece that, besides presenting the contemporary author’s characteristics, shows the aspects of two important writers in the 20th century, Fernando Pessoa and Luigi Pirandello. The introduction also brings some biographical and bibliographical data about the involved authors. In the development section, before the translation itself, there is a selection of comments about the translated play, with the objective of contributing to the constitution of the Brazilian reader’s context. In our conclusion, there are the last comments about the translation and the importance of the monography to its writer

Investigação sobre deformação neotectônica no lineamento Guapiara, região de Ourinhos, Fartura-SP e Santo Antonio da Platina - PR

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Goppa codes over certain semigroups

A Goppa code is described in terms of a polynomial, known as Goppa polynomial, and in contrast to cyclic codes, where it is difficult to estimate the minimum Hamming distance d from the generator polynomial. Furthermore, a Goppa code has the property that d ≥ deg(h(X))+1, where h(X) is a Goppa polynomial. In this paper, we present a decoding principle for Goppa codes constructed by generalized polynomials, which is based on modified Berlekamp-Massey algorithm.

Planejamento e controle da produção: reestruturação no layout de apertadeiras eletrônicas em uma linha de produção do ramo de autopeças

In industrial plants, there is a department responsible for planning the use of productive resources to find the best possible way to set out plans in strategic, tactical and operational levels. This department is known as PCP or PPCP, which means Planning and Production Control and Planning, Programming and Production Control, respectively. This work presents the use of some of the tools from this department, in particular the Aggregate Production Planning, to propose a new layout of electronic nutrunners for an auto parts industry output line. Through some process indicators analyzes, was identified some productivity losses. The higher loss rate occurred by the electronic nutrunners breaking, and so this work was focused in these devices. Some premises were adopted for the use of electronic nut runners, setting an ideal cycle time for the operation of the production line and making calculations to define the minimum amount of electronic nutrunners to find the production demand without damaging the equipment. With this work we observed that a relevant factor for the constant breaks of electronic nutrunners is because these are working with overload, in other words, the amount of installed equipment is not enough to supply the demand without failures

Atenolol characterization in solid formulations available in Brazilian market

Atenolol is the most used drug in Brazil to hypertension treatment. Two crystal structures are known for this molecule: a racemic form (R,S)-atenolol and a pure form S-atenolol. The racemic form is found in commercial tablets. X-ray powder diffraction (XRD) is an adequate tool to study crystalline structures including drugs. Using the Rietveld Method with XRD data it is possible to quantify the crystalline structures existing in the raw material. Other methods like Le Bail and Pawley can be used to the profile fit and phases identification. For this work we analyzed three tablets of atenolol, two generics and the reference (materials were purchased from a drugstore at the city of Araraquara). These tablets were analyzed by Rietveld, Le Bail and Pawley methods. All tablets exhibited the racemic mixture API (R,S)-atenolol. Some crystalline excipients could be characterized: magnesium carbonate hydrate, lactose monohydrate and talc. The conclusion is that the three methods can be efficiently used to characterize the three atenolol tablets.

High activity photocatalyst powder formed by three ceramic oxides

A Photocatalyst ceramic powder that presented high photoactivity based on TiO2 modified with 25% molar of SnO2 and up to 5% molar of Ag2O was obtained in the present work. The aforementioned ceramic powder was obtained using all commercial oxides as well as the oxides mixture technique. The powders were ground in high energy mill for one hour with subsequent thermal treatment at 400°C for four hours. They were, furthermore, characterized using surface area of around 6m2/g, where the X-Ray diffraction results provided evidence for the presence of anatase and rutile phases, known to be typical characteristics of both the TiO2 and SnO2 used. During the thermal treatment, Ag2O was reduced to metallic silver. The photodegradation rehearsals were carried out using a 0.01 mmol/L Rhodamine B solution in a 100mg/L photocatalyst suspension in a 500ml beaker, which was irradiated with 4W germicide Ultraviolet light of 254nm. In addition, samples were removed after duration of about 10 minutes to an hour, where they were analyzed thoroughly in UV-vis spectrophotometer. The analysis of the results indicated that for the compositions up to 2.5% molar of Ag2O, the photoactivity was found to be greater than that of Degussa P25 photocatalyst powder, and as such it was then used as a reference. Taking into account 90% degradation of Rhodamine B, a duration period of 11 minutes was obtained for the developed photocatalyst powder compared to the 38 minutes observed for the Degussa P25. FEG-SEM micrographies enabled the verification of the morphology as well as the interaction of the oxide particles with the metallic silver, which led us to propose a model for the increase in photoactivity observed in the photocatalyst powder under investigation.

Antonio Candido, leitor de poesia

Este artigo objetiva, a partir de estudos de Antonio Candido voltados para a poesia lírica, rastrear o pensamento estético e crítico-teórico do autor sobre a matéria, bem como avaliar sua prática analítica do texto poético. Tal prática, coerente com o postulado na vasta obra do autor, ancora-se em dois eixos principais: o “árcade/ romântico” (voltado para o período formativo da literatura brasileira) e o “modernista” (que enfatiza a consolidação plena de nossa literatura).

As duas culturas: Antonio Candido e a formação da sociologia e da literatura no Brasil

Antonio Candido, author of fundamental papers to understand Brazil’s cultures process formation, in his works about sociology and literature formation, he draws an explanation of these process of cultural genesis by mean of referential and functional systems, that become possible Brazilian society expression though scientific and literary cultures. These processes and explanations look at for functional correlations between elements and system by mean of relationship between authors-works-receptors, nevertheless, it must to investigate the individual contributions of authors and works to formation of shapes and directions of system.