Post-axial polydactyly type A2, overgrowth and autistic traits associated with a chromosome 13q31.3 microduplication encompassing miR-17-92 and GPC5.

Genomic rearrangements at chromosome 13q31.3q32.1 have been associated with digital anomalies, dysmorphic features, and variable degree of mental disability. Microdeletions leading to haploinsufficiency of miR17∼92, a cluster of micro RNA genes closely linked to GPC5 in both mouse and human genomes, has recently been associated with digital anomalies in the Feingold like syndrome. Here, we report on a boy with familial dominant post-axial polydactyly (PAP) type A, overgrowth, significant facial dysmorphisms and autistic traits who carries the smallest germline microduplication known so far in that region. The microduplication encompasses the whole miR17∼92 cluster and the first 5 exons of GPC5. This report supports the newly recognized role of miR17∼92 gene dosage in digital developmental anomalies, and suggests a possible role of GPC5 in growth regulation and in cognitive development.

Berlin 17/2 -32

Kirje 17.2.1932

Tasavallan Presidentin valtiovierailu Neuvostoliittoon 17.-24.5.1977 (Neuvostoliiton television välittämä Tasavallan Presidentin tervehdys 18.5.1977)

Puhe

La Bible : traduction nouvelle avec l'hébreu en regard, accompagné des points-voyelles et des accens toniques ( @ ) avec des notes philologiques, géographiques et littéraires, et les principales variantes de la version des Septante et du texte samaritain.... Tome 17 / par S. Cahen...

[Bible. A.T. (hébreu-français). 1831-1851]

Hina 17/11 1942

Kirje 17.11.1942

Varatuomari Ilmari Turja 17/5 1974

Kirje 17.5.1974

[Tasavallan Presidentin valtiovierailu Neuvostoliittoon 12.-17.11.1980] (Tasavallan Presidentin kiitospuhe Leninin rauhanpalkinnon luovutustilaisuudessa Kremlissä 13.11.1980)

Puhe

Hina 17.3.1944

Kirje

Ent. toimitusjohtaja Ville Pörhölä 17/11 1964

Kirje 17.11.1964