George Day Welsh nas relações entre a Madeira e os Estados Unidos da América (primeira metade do século XIX)

Tendo este trabalho como objecto de estudo a personalidade do cidadão americano George Day Welsh, radicado na Madeira no início do século XIX, pretende-se caracterizar, ao longo desta dissertação, os elementos fundamentais das relações entre a Ilha da Madeira e os Estados Unidos da América, aos níveis político, económico, social e cultural, e apenas no período relativo à primeira metade do século XIX. Organizado em quatro partes fundamentais (onde não se incluem nem a apresentação inicial que se segue, nem os apêndices finais de documentos e de gravuras antigas), este estudo começa por, na primeira parte, descrever as relações de Portugal com a Inglaterra e, em particular, com os Estados Unidos da América, país de origem de George Day Welsh, não deixando também de documentar a ida de marinheiros assim como a presença de madeirenses nos Estados Unidos da América. Na segunda parte, começando a traçar o percurso biográfico de George Day Welsh, descrevem-se os seus negócios e as suas acções em alguns dos concelhos da Madeira, dando igualmente uma especial atenção ao período da Guerra Civil, às relações concorrenciais entre aquele cidadão americano e John Marsh, assim como ao papel cultural de George Welsh na Madeira. As relações familiares de Welsh na Madeira são o assunto da terceira parte, onde se focam as questões relacionados com a sua chegada à Ilha, o seu casamento, a sua descendência, e a sua proximidade em relação a outros madeirenses ilustres, como é o caso do Conde de Carvalhal. Na conclusão final desta dissertação, referem-se não só as ideias principais deste percurso de investigação como algumas pistas para aperfeiçoá-lo e completá-lo.

Inovações institucionais na pesquisa agrícola na América Latina e no Caribe

PEDRO, Edilson da Silva; SALLES-FILHO, Sergio; MENDES, Paule Jeane. Inovações Institucionais na Pesquisa Agrícola na América Latina e no Caribe. In: SIMPOSIO DE GESTAO DA INOVAÇAO TECNOLOGICA, 24., 2006, Gramado. Anais...Gramado: ANPAD, 2006.

Dançando às avessas: relatos de um processo de criação

The term body without organs is present in a poem by the french writer, actor and director Antonin Artaud, written in 1947 and titled: To Have Done with the Judgement of God. I aim, in this work, from what we call investigative scenic writing, to problematize this term and its possible relations with the theater and also with some aspects of the Hindu myths. I unite the idea of the body without organs with the body in trance present in the stories of an Indian master named Caitanya Mahaprabhu. These ideas, along with the development of practices that come from some principles of Theatre Anthropology, are incentives for a creation process that highlights the work of preparation and creation of corporeal work of the actor. The relationship between the concepts and the practice raise discussions about where I stand as an actor-researcher in process

Caracterização e quantificação de marcadores químicos do extrato hidroetanólico das folhas de Kalanchoe brasiliensis Cambess

Kalanchoe brasiliensis Cambess (Crassulaceae), commonly known as saião , coirama branca , folha grossa , is originally from Brazil and commonly found in São Paulo to Bahia, mainly in the coastal zone. Regarding of biological activities, most preclinical studies were found in the literature, mainly about the anti-inflammatory activity of extracts obtained from leaves and / or aerial parts of K. brasiliensis. As regards the chemical constitution, it has been reported mainly the presence of flavonoids in the leaves of the species, but until this moment did not knows which are the active compounds. Although it is a species widely used in traditional medicine in Brazil, there is no monograph about the quality parameters of the plant drug. In this context, this study aims to characterize and quantify the chemical markers of hydroethanolic extract (HE) from the leaves of K. brasiliensis, which can be used in quality control of plant drug and derivatives obtained from this species. The methodology was divided into two parts: i. Phytochemical study: to fractionate, isolate and characterizate of the chemical (s) marker (s) of the HE from the leaves of K. brasiliensis; ii. To Developed validate of analytical method by High Performance Liquid Chromatography (HPLC)-diode array detector (DAD) to quantify the chemical (s) marker (s) of the EH. i. The EH 50% was prepared by turbo extraction method. It was then submitted to liquid-liquid partition, obtaining dichloromethane, n-butanol and ethyl acetate (AcOEt) fractions. The AcOEt fraction was selected to continue the fractionation process, because it has a chemical profile rich in flavonoids. The acOEt fraction was submitted to column chromatography using different systems for obtaining the compound Kb1. To identify this compound, it was submitted to UV analysis ii. For quantitative analysis, the EH was analyzed by HPLC, using different methods. After selecting the most appropriate method, which showed satisfactory resolution and symmetrical peaks, it was validated according to parameters in the RE 899/2003. As result, it was obtained from the AcOEt fraction the compound Kb1 (2.7 mg). Until this moment, the basic nucleus was characterized by UV analysis using shift reagents. The partial chemical structure of the compound Kb1 was identified as a flavonol, containing hydroxyls in 3 , 4 position (ring A), 5 and 7 free (ring B) and a replacement of the C3 hydroxyl by a sugar. As the analysis were performed in the HPLC coupled to a DAD, we observed that the UV spectrum of the major peaks of EH from K. brasiliensis shown similar UV spectrum. According to the literature, it has been reported the presence of patuletin glycosydes derivatives in the leaves of this species. Therefore, it is suggested that the compound Kb1 is glycosylated patuletin derivative. Probably the sugar (s) unit(s) are linked in the C3 in the C ring. . Regarding the development of HPLC analytical method, the system used consists of phase A: water: formic acid (99,7:0,3, v / v) and phase B: methanol: formic acid (99,7:0,3, v / v), elution gradient of 40% B - 58% B in 50 minutes, ccolumn (Hichrom ®) C18 (250x4, 0 mm, 5 μm), flow rate 0.8 mL / min, UV detection at 370 nm, temperature 25 ° C. In the analysis performed with the co-injection of thecompound Kb1 + HE of K. brasiliensis was observed that it is one of the major compounds with a retention time of 12.47 minutes and had a content of 15.3% in EH of leaves from K. brasiliensis. The method proved to be linear, precise, accurate and reproducible. According to these results, it was observed that compound Kb1 can be used as a chemical marker of EH from leaves of K. brasiliensis, to assist in quality control of drug plant and its derivatives