Characterization of a genomic signature of pregnancy identified in the breast.

The objective of this study was to comprehensively compare the genomic profiles in the breast of parous and nulliparous postmenopausal women to identify genes that permanently change their expression following pregnancy. The study was designed as a two-phase approach. In the discovery phase, we compared breast genomic profiles of 37 parous with 18 nulliparous postmenopausal women. In the validation phase, confirmation of the genomic patterns observed in the discovery phase was sought in an independent set of 30 parous and 22 nulliparous postmenopausal women. RNA was hybridized to Affymetrix HG_U133 Plus 2.0 oligonucleotide arrays containing probes to 54,675 transcripts, scanned and the images analyzed using Affymetrix GCOS software. Surrogate variable analysis, logistic regression, and significance analysis of microarrays were used to identify statistically significant differences in expression of genes. The false discovery rate (FDR) approach was used to control for multiple comparisons. We found that 208 genes (305 probe sets) were differentially expressed between parous and nulliparous women in both discovery and validation phases of the study at an FDR of 10% and with at least a 1.25-fold change. These genes are involved in regulation of transcription, centrosome organization, RNA splicing, cell-cycle control, adhesion, and differentiation. The results provide initial evidence that full-term pregnancy induces long-term genomic changes in the breast. The genomic signature of pregnancy could be used as an intermediate marker to assess potential chemopreventive interventions with hormones mimicking the effects of pregnancy for prevention of breast cancer.

L'Écho de Paris

1903/12/20 (Numéro 7140).

L'Écho de Paris

1885/01/10 (Numéro 305).

Police et patrie : organe des éléments résistants de la Police française adhérents au mouvement "Libération"

1944/06 (N2).

Police et patrie : organe des éléments résistants de la Police française adhérents au mouvement "Libération"

1944/07 (N4).

Police et patrie : organe des éléments résistants de la Police française adhérents au mouvement "Libération"

1944/04 (N1).

Police et patrie : organe des éléments résistants de la Police française adhérents au mouvement "Libération"

1944/06 (N3).

Police et patrie : organe des éléments résistants de la Police française adhérents au mouvement "Libération"

1944/08 (FASC5).

Biblia sacra, pars II.

Avec prologues. Ezechiel (1v) ; Daniel (32v) ; XII Proph. min. (45v) ; Isaias (75v) ; Jeremias (104v) ; Jeremiae Lament. et Oratio (138, 141) ; Baruch (141v). — Actus Apost. (145) ; VII Epist. canon. (164v) ; XIV Epist. Pauli (175) ; Apocalypsis I,1-XXII,13 (220v).

Vetus Testamentum, pars.

Genesis I,29-L,25 (avec l'Épître de S. JEROME incomplète de la fin) (4) ; Exodus (27) ; Levit. (49) ; Numeri (63v) ; Deuteron. (85) ; Josue cum prol. (105, 106) ; Judices (121) ; Ruth (134v).

Biblia sacra, pars.

Avec prologues. Evang. Matthaei (2), Marci (45v), Lucae (72v), Johannis (116) ; Actus Apost. (148v) ; Apocalypsis (186v) ; VII Epist. canon. (205) ; XIV Epist. Pauli (222). F. 1v Addition : Ezechiel, XXXV, 1-5 et Jeremias, IV, 7. F. 305 Calendrier de Florence, avec des additions (dans le sens dominicain).

Missale ad usum Carmelitarum.

F. 2 Calendrier des Carmes, avec additions du XVIe s. F. 8-123v et 137v-216v Temporal « secundum usum dominici Sepulchri » (8). F. 124-137 Préfaces, canon, ordo missae. F. 216v-287v Sanctoral : — Onze mille Vierges (277). F. 288 Commun des saints. F. 318 Messes votives et diverses.

Anatomie & physiologie animales / par Gaston Bonnier,...

Collection : Collection Paul Dupont