Tohtori Johannes Virolainen 6/6 1972

Kirje 6.6.1972

Helsinki 24/6 1941

Kirje 24.6.1941

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker.

The detection of Parkinson's disease (PD) in its preclinical stages prior to outright neurodegeneration is essential to the development of neuroprotective therapies and could reduce the number of misdiagnosed patients. However, early diagnosis is currently hampered by lack of reliable biomarkers. (1) H magnetic resonance spectroscopy (MRS) offers a noninvasive measure of brain metabolite levels that allows the identification of such potential biomarkers. This study aimed at using MRS on an ultrahigh field 14.1 T magnet to explore the striatal metabolic changes occurring in two different rat models of the disease. Rats lesioned by the injection of 6-hydroxydopamine (6-OHDA) in the medial-forebrain bundle were used to model a complete nigrostriatal lesion while a genetic model based on the nigral injection of an adeno-associated viral (AAV) vector coding for the human α-synuclein was used to model a progressive neurodegeneration and dopaminergic neuron dysfunction, thereby replicating conditions closer to early pathological stages of PD. MRS measurements in the striatum of the 6-OHDA rats revealed significant decreases in glutamate and N-acetyl-aspartate levels and a significant increase in GABA level in the ipsilateral hemisphere compared with the contralateral one, while the αSyn overexpressing rats showed a significant increase in the GABA striatal level only. Therefore, we conclude that MRS measurements of striatal GABA levels could allow for the detection of early nigrostriatal defects prior to outright neurodegeneration and, as such, offers great potential as a sensitive biomarker of presymptomatic PD.

Radiopuhe 6.4.1950

Puhe

Motor Vehicle Crash Fatalities for Week Ending, June 6, 2008

Motor Vehicle Crash Fatalities

Berlin 6/2 -32

Kirje 6.2.1932

V[altiopäivä]J[ärjestykse]:n 6 }:n muuttaminen, Lk

Puhe

Os Interesses e as Escolhas Profissionais de Acordo com os 6 Tipos de Personalidade Propostos por Holland (Riasec) numa Amostra de Estudantes do Ensino Superior em Cabo Verde

Tendo por base a teoria dos interesses e das escolhas vocacionais e o modelo RIASEC propostos por Holland, (1973, 1985, 1997) a presente investigação pretende saber como se caracterizam os interesses profissionais dos alunos que frequentam diferentes Cursos Superiores em Cabo Verde e avaliar as características psicométricas do instrumento utilizado. Pretende-se ainda averiguar se existe congruência ou não entre os interesses dos estudantes e os cursos que frequentam, bem como verificar se há diferenças nos interesses avaliados em função do género e do estatuto socioeconómico. Nesta investigação participaram 250 estudantes de três instituições de Ensino Superior da Cidade da Praia, Ilha de Santiago em Cabo Verde. Foi aplicado o Inventário de Interesse de Exploração Autodirigida (SDS), versão em língua portuguesa (Primi, Mansão, Muniz, & Nunes, 2010). Os resultados obtidos confirmam as adequadas características psicométricas do instrumento nesta população e estão de acordo com as previsões do modelo acima referido

Rouva Ellen Fagerlund Wyke 20/6 1967

Kirje