Diazepam, em dose única, inibe a migração celular, a estimulação macrofágica e a atividade de TNF-α na reação inflamatória aguda induzida por LPS em camundongos

Benzodiazepines are one of the most frequently prescribed drugs due to their anxiolytic properties. The aim of this study was to evaluate the effects of diazepam on lipopolysaccharide-induced peritoneal acute inflammatory responses. Swiss mice were treated with diazepam in a single dose of 1 or 10 mg/kg- subcutaneously 1 h before an intraperitoneal injection of lipopolysaccharide or sterile saline solution. The mice were killed 16 h after and the cells were washed from the peritoneal cavity to determine the total number of cells and the mononuclear and polimorfonuclear subpopulations, as well as the TNF-alpha activity and percentage of spread macrophages. Our results showed that the diazepam treatment (1 and 10 mg/kg) induced a significant reduction in the LPS-induced macrophage stimulation and TNF-α activity. Diazepam (10 mg/kg) also reduced the inflammatory cellular migration when compared to the control. It can be concluded that the diazepam treatment in a single dose is able to influence the inflammatory cellular influx, macrophage stimulation and TNF-α activity in the acute inflammatory response in mice, having possible implications on the anti-infectious response efficiency.

Ação extra-nuclear do hormônio triiodotironina (T3) na expressão gênica de HIF-1α e TGFα em linhagem celular de adenocarcinoma mamário

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Migração e invasão celular in vitro de células humanas expressando variantes da oncoproteína LMP1 do vírus de Epstein-Barr (EBV)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Viabilidade do recipiente biodegradável na produção de mudas florestais nativas

Pós-graduação em Ciência Florestal - FCA

Viabilidade e eficiência de óleos essenciais no manejo do míldio da videira

Pós-graduação em Agronomia - FEIS

Cinéticas de espumación y control de la estructura celular en materiales basados en caucho natural y poliolefinas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Viabilidade agroeconômica do consórcio de couve com espinafre 'Nova Zelândia'

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Procedimentos para o dimensionamento de reservatório de água pluvial para residências unifamiliares: viabilidade e aprimoramento metodológico

This paper focus to apply, to discuss and to propose the Maximum Harvesting Method improvement, regarding the method application, for household rainwater harvesting systems. For this purpose, the rainwater was considered to supply the flush toilet demand in a household for 3, 4, and 5 inhabitants. The 80, 120 and 200m2 catchments areas and the 0, 1, 2 and 4mm first flushes discharges were also considered. Further, the improvement suggestions for cistern volume calculus and volume/level dynamics variation in a period were presented and the results were compared applying the Simulation Analyses Method. The results indicate that the Maximum Harvesting Method could be applied and that the improvement proposal can be used to determinate the cistern volume as well to analyze the dynamic behavior of volume/level, constituting by itself a single tool to assist rainwater harvesting systems designers.

Using Pichia pastoris to produce recombinant glycerol kinase

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Adição de ácido linolênico e L-carnitina na maturação oocitária: efeitos sobre o metabolismo celular, potencial de desenvolvimento e criotolerância de embriões bovinos produzidos in vitro

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeito de parâmetros variáveis de fermentação sobre o crescimento celular e composição química do fermentado de batata-doce

This study aimed to evaluate the use of sweet potato as a substrate for the production of spirits. In order to promote an alternative technologically feasible, an experimental design was performed to minimize the operations of preparation, defining the most adequate conditions for the fermentation process. From sweet potato flour obtained by milling and dehydration process of the roots was carried out an enzymatic process of hydrolysis-saccharification of suspension of sweet potato flour with 18% dry matter. The hydrolyzate was used in the fermentation process which followed the 23 full factorial experimental design with central and axial points, and the independent variables were the concentration of reducing sugars, concentration of viable yeast and fermentation temperature. The dependent variables were viable cells, residual sugar, ethanol, glycerol and methanol. The dependent variables were quantified by liquid chromatography. The data analysis indicate that the best fermentation conditions among the tested conditions were: concentration of yeast 5 x 107-1 x 108 in number of viable cells, total reducing sugars from 12.5 to 13.5% and temperature between 33 -34ºC.

Estudo da viabilidade econômica da implantação de incineradores de RSU na Região de Bauru

A principal preocupação relacionada à produção de resíduos tem sido o manejo e a gestão integrada, procedimentos que passaram a fazer parte das políticas de gestão com o objetivo de evitar problemas irreversíveis ao meio ambiente e aos seres humanos. Neste trabalho estuda-se a possibilidade da incineração dos Resíduos Sólidos Urbanos (RSU) como solução para o problema relacionado com a destinação dos resíduos gerados na Região de Bauru. Estimar os custos de capital e a viabilidade econômica para o projeto de incineradores de larga escala é uma tarefa prioritária para auxiliar o processo de tomada de decisão. Este trabalho revê a situação dos resíduos sólidos na região de Bauru e realiza revisão dos processos empregados e existentes no tratamento dos RSU com o objetivo de analisar a viabilidade da implantação de uma usina de incineração com geração de energia elétrica para o tratamento dos resíduos sólidos coletados na Região de Bauru. O estudo apresenta um retorno interessante ao passo que as simulações apresentam indicadores favoráveis a sua implantação.

Análise da viabilidade do uso de biogás gerado a partir de dejetos bovinos em microturbinas para fins de geração, cogeração e trigeração de energia

The use of digesters has become an important alternative for the proper disposal of organic agricultural wastes, serving as a solution to some environmental and health problems. Furthermore, the process of digestion provides commercially valuable by products such as biogas and bio fertilizer. The generation of biogas from agricultural waste, and its use in power generation systems has aroused great interest in rural areas because it enables supply in whole or in large part the energy demand of ownership by reducing production costs. The advent of technology has brought new forms of energy conversion of biogas, as the use of micro turbines specifies to be fuelled with biogas derived from the decomposition of organic matter in digesters, since it has a low level of methane in its composition, and high degree of impurities such as hydrogen sulphide, which are harmful to equipment and reduce the calorific value of biogas. The use of micro turbines behind other advantages like low emissions, great fuel flexibility and low maintenance. This paper presents an analysis of the feasibility of using biogas generated from cattle manure in micro turbines to generate electricity. Behind also an assessment of the energy potential that each animal has on various uses of biogas, and forms of energy recovery from the exhaust gases of the micro turbine. Also conducts an evaluation of the energy savings that the use of biogas aggregates properties.