In Utero Exposure to Antiretroviral Drugs: Effect on Birth Weight and Growth Among HIV-exposed Uninfected Children in Brazil.

BACKGROUND There are concerns about the effects of in utero exposure to antiretroviral drugs (ARVs) on the development of HIV-exposed but uninfected (HEU) children. The aim of this study was to evaluate whether in utero exposure to ARVs is associated with lower birth weight/height and reduced growth during the first 2 years of life. METHODS This cohort study was conducted among HEU infants born between 1996 and 2010 in Tertiary children's hospital in Rio de Janeiro, Brazil. Weight was measured by mechanical scale, and height was measured by measuring board. Z-scores for weight-for-age (WAZ), length-for-age (LAZ) and weight-for-length were calculated. We modeled trajectories by mixed-effects models and adjusted for mother's age, CD4 cell count, viral load, year of birth and family income. RESULTS A total of 588 HEU infants were included of whom 155 (26%) were not exposed to ARVs, 114 (19%) were exposed early (first trimester) and 319 (54%) later. WAZ were lower among infants exposed early compared with infants exposed later: adjusted differences were -0.52 (95% confidence interval [CI]: -0.99 to -0.04, P = 0.02) at birth and -0.22 (95% CI: -0.47 to 0.04, P = 0.10) during follow-up. LAZ were lower during follow-up: -0.35 (95% CI: -0.63 to -0.08, P = 0.01). There were no differences in weight-for-length scores. Z-scores of infants exposed late during pregnancy were similar to unexposed infants. CONCLUSIONS In HEU children, early exposure to ARVs was associated with lower WAZ at birth and lower LAZ up to 2 years of life. Growth of HEU children needs to be monitored closely.

Are there age-, strain-, and sex-differences in the prolonged exposure to methylphenidate?

Repeated treatment with psychostimulants produces behavioral sensitization that results in increased locomotor responses so that lower drug doses are required to obtain the same effect and cross-sensitization with other stimulants. Methylphenidate (MPD; Ritalin) is most frequently prescribed to treat children having attention deficit hyperactivity disorder (ADHD), a syndrome with onset in childhood characterized by high levels of inattention, hyperactivity, and impulsivity. Little is known of the consequences involving the long-term use of MPD as treatment for ADHD. This study investigates if there are age, genetic/strain, and sex differences in the prolonged exposure to MPD and cross-sensitization with amphetamine. The objective is to determine whether (a) early exposure to MPD in adolescent rats increases their sensitivity to the drug when they are adult rats, (b) there are strain and sex differences in the response to MPD, and (c) treatment with MPD in adolescent and adult Wistar-Kyoto (WKY), spontaneously hyperactive/hypertensive rat (SHR), and Sprague-Dawley (SD) rat results in cross-sensitization with amphetamine. The hypotheses are that (1) early exposure to MPD in adolescent rats increases their sensitivity to the drug when they reach adulthood, and that this hypersensitivity is dose-, strain-, and sex-dependent and (2) adult rats treated with MPD as adolescents will show a greater cross-sensitization to amphetamine than those adult rats treated with saline as adolescents, and that this cross-sensitization is dose-, strain-, and sex-dependent. The study consists of recording and evaluating locomotor activity of female and male WKY, SHR, and SD rats before and after acute and repeated MPD administration when these rats are young and as adults follows by an amphetamine treatment. Results showed that repeated treatment with MPD elicited behavioral sensitization and cross-sensitization with amphetamine in these animals. The study also found that strain and sex play a crucial role in the differentiated sensitivity to the acute and chronic effects of MPD. The development of behavioral sensitization and cross-sensitization are also dependent on the dose of MPD and the age of the rat. ^

Factors contributing to the attrition of women in the African-American Nutrition for Life study

Background. There is currently a push to increase the number of minorities in cancer clinical trials in an effort to reduce cancer health disparities. Overcoming barriers to clinical trial research for minorities is necessary if we are to achieve the goals of Healthy People 2010. To understand the unexpectedly high rate of attrition in the A NULIFE study, the research team examined the perceived barriers to participation among minority women. The purpose of this study was to determine if either personal or study-related factors influenced healthy pre-menopausal women aged 25-45 years to terminate their participation in the A NULIFE Study. We hypothesized that personal factors were the driving forces for attrition rates in the prevention trial.^ Methods. The target population consisted of eligible women who consented to the A NULIFE study but withdrew prior to being randomized (N= 46), as well as eligible women who completed the informed consent process for the A NULIFE study and withdrew after randomization (N= 42). Examination of attrition rates in this study occurred at a time point when 10 out of 12 participant groups had completed the A NULIFE study. Data involving the 2 groups that were actively engaged in study activities were not used in this analysis. A survey instrument was designed to query the personal and study-related factors that were believed to have contributed to the decision to terminate participation in the A NULIFE study.^ Results. Overall, the highest ranked personal reason that influenced withdrawal from the study was being “too busy” with other obligations. The second highest ranked factor for withdrawal was work obligations. Whereas, more than half of all participants agreed that they were well-informed about the study and considered the study personnel to be approachable, 54% of participants would have been inclined to remain in the study if it were located at a local community center.^ Conclusions. Time commitment was likely a major factor for withdrawal from the A NULIFE study. Future investigators should implement trials within participant communities where possible. Also, focus group settings may provide detailed insight into factors that contribute to the attrition of minorities in cancer clinical trials.^

Mid-Wisconsin to Holocene permafrost and landscape dynamics based on a drained lake basin core from the northern Seward Peninsula, Northwest Alaska

Permafrost-related processes drive regional landscape dynamics in the Arctic terrestrial system. A better understanding of past periods indicative of permafrost degradation and aggradation is important for predicting the future response of Arctic landscapes to climate change. Here, we used a multi-proxy approach to analyze a ~4 m long sediment core from a drained thermokarst lake basin on the northern Seward Peninsula in western Arctic Alaska (USA). Sedimentological, biogeochemistical, geochronological, micropaleontological (ostracoda, testate amoeba) and tephra analyses were used to determine the long-term environmental Early-Wisconsin to Holocene history preserved in our core for Central Beringia. Yedoma accumulation dominated throughout the Early to Late-Wisconsin but was interrupted by wetland formation from 44.5 to 41.5 ka BP. The latter was terminated by deposition of 1 m of volcanic tephra, most likely originating from the South Killeak Maar eruption at about 42 ka BP. Yedoma deposition continued until 22.5 ka BP and was followed by a depositional hiatus in the sediment core between 22.5 and 0.23 ka BP. We interpret this hiatus as due to intense thermokarst activity in the areas surrounding the site, which served as a sediment source during the Late-Wisconsin to Holocene climate transition. The lake forming the modern basin on the upland initiated around 0.23 ka BP, which drained catastrophically in spring 2005. The present study emphasizes that Arctic lake systems and periglacial landscapes are highly dynamic and permafrost formation as well as degradation in Central Beringia was controlled by regional to global climate patterns and as well as by local disturbances.

(Table 1) Sea ice and snow characteristics and heat fluxes observed during R/V Aurora Australis cruise to East Antarctica in September/October 2007

The properties of snow on East Antarctic sea ice off Wilkes Land were examined during the Sea Ice Physics and Ecosystem Experiment (SIPEX) in late winter of 2007, focusing on the interaction with sea ice. This observation includes 11 transect lines for the measurement of ice thickness, freeboard, and snow depth, 50 snow pits on 13 ice floes, and diurnal variation of surface heat flux on three ice floes. The detailed profiling of topography along the transects and the d18O, salinity, and density datasets of snow made it possible to examine the snow-sea-ice interaction quantitatively for the first time in this area. In general, the snow displayed significant heterogeneity in types, thickness (mean: 0.14 +- 0.13 m), and density (325 +- 38 kg/m**3), as reported in other East Antarctic regions. High salinity was confined to the lowest 0.1 m. Salinity and d18O data within this layer revealed that saline water originated from the surface brine of sea ice in 20% of the total sites and from seawater in 80%. From the vertical profiles of snow density, bulk thermal conductivity of snow was estimated as 0.15 W/K/m on average, only half of the value used for numerical sea-ice models. Although the upward heat flux within snow estimated with this value was significantly lower than that within ice, it turned out that a higher value of thermal conductivity (0.3 to 0.4 W/K/m) is preferable for estimating ice growth amount in current numerical models. Diurnal measurements showed that upward conductive heat flux within the snow and net long-wave radiation at the surface seem to play important roles in the formation of snow ice from slush. The detailed surface topography allowed us to compare the air-ice drag coefficients of ice and snow surfaces under neutral conditions, and to examine the possibility of the retrieval of ice thickness distribution from satellite remote sensing. It was found that overall snow cover works to enhance the surface roughness of sea ice rather than moderate it, and increases the drag coefficient by about 10%. As for thickness retrieval, mean ice thickness had a higher correlation with ice surface roughness than mean freeboard or surface elevation, which indicates the potential usefulness of satellite L-band SAR in estimating the ice thickness distribution in the seasonal sea-ice zone.

Compañeros de ruta, reencuentro de ex presos políticos cordobeses

El propósito de este trabajo es investigar los motivos, anhelos, sueños, deseos que llevan a un grupo de entre 20 y 25 ex presos políticos a reunirse semanalmente en el local del sindicato Luz y Fuerza, Córdoba. Optamos por entrevistar a quienes daban la sensación de ser más participativos o más explícitos, en la elección procuramos que hubiesen casi por igual miembros de las dos organizaciones mayoritarias en el pasado: Montoneros y Partido Revolucionario de los Trabajadores. El celo a la hora de elegir se entronca con las subculturas que emergieron de las organizaciones. Otro aspecto observado es la cuestión de género, mujeres y hombres, equitativamente incorporados, se constituyeron en narradores.2 En la ciudad mediterránea hubo alrededor de dos mil detenidos por causas políticas a partir de la dictadura que iniciara Jorge Rafael Videla. La curiosidad social es acicateada por el número exiguo de ex-represaliados que constituyen la comisión de presos políticos, que entre otras tareas peticiona ante las autoridades solicitando reivindicaciones a raíz de su condición de ex detenidos, organizan eventos sociales y políticos, gestionan los ex centros de detención convertidos en "museos de la memoria", impulsan los juicios contra los ex represores, editan publicaciones. Concurrimos a las reuniones semanales, a asados, "locreadas"; empleamos en las investigaciones la observación participante. La participación se dio en eventos, en compartir ruedas de mate en la casa de los entrevistados, íntimas ruedas de café, por un fenómeno de indexicalidad en relación con el discurso ideológico pudimos avanzar en la profundidad de la conversación. Además, de las entrevistas en profundidad, analizamos material periodístico y material escrito por los detenidos; cuando la emoción del entrevistado dificultaba la conversación, en algunos casos nos remitieron a elaboraciones suyas sobre la situación planteada.. Nos favoreció, en el trabajo, el hecho de haber participado en la vida política, y el tener familiares que lucharon junto a los ex-represaliados. A pesar de ello no fue fácil llegar a subjetividades que hacía largo tiempo se hallaban abroqueladas. Mead e Erving Goffman nos acompañaron en el camino de reconocimiento de los selfs en la dramaturgia montada en el local de Luz y Fuerza

Le Goff : Balance crítico de un legado

Los primeros trabajos de Jacques Le Goff, sobre mercaderes, banqueros e intelectuales de la Edad Media, presentan cualidades que anuncian su desarrollo posterior: débil teoría económica y mayor desarrollo sobre historia de las ideas. A partir de 1964, con la publicación de La civilización del occidente medieval, se produce un cambio. Ese cambio se inscribe en una nueva orientación general de la escuela de Annales: el estudio de las mentalidades. Le Goff pretende realizar un análisis de la mentalidad del hombre medieval. Su estudio se basa principalmente en textos eruditos eclesiásticos. Se demuestra en este artículo que ese tipo de fuentes permiten acceder a la mentalidad de la parte sacerdotal de la clase de poder. De manera secundaria, Le Goff estudió fuentes literarias que permiten acercarse a la mentalidad de los caballeros. Para el análisis de los campesinos y de distintos sectores subalternos se necesitarían otro tipo de fuentes que nunca fueron utilizadas por Le Goff. Este análisis mantiene algunas semejanzas con el materialismo histórico, pero también tiene profundas diferencias con la doctrina de Marx. En base a esto se determina el alcance del legado de Le Goff

Pliocene to Pleistocene planktonic foraminiferal datum levels in the North Pacific

Continuous late Neogene planktonic foraminiferal records have been studied in the deep-sea cores of DSDP Sites 173, 310, and 296 across mid-latitudes of the North Pacific. These three sites have been correlated on the basis of planktonic foraminiferal events and major paleoclimatic/paleoceanographic intervals and tied to diatom, radiolarian, and nannofossil datum levels, and paleomagnetic and isotopic stratigraphy. Ten planktonic foraminiferal datum levels have been recognized within these Pliocene to Pleistocene sections; two of these are recognizable within the Pleistocene and eight within the Pliocene. Six planktonic foraminiferal zones are proposed which combined with the foraminiferal datum levels provide a high resolution biostratigraphic correlation for the mid-latitudes of the North Pacific.

Le Goff : Balance crítico de un legado

Los primeros trabajos de Jacques Le Goff, sobre mercaderes, banqueros e intelectuales de la Edad Media, presentan cualidades que anuncian su desarrollo posterior: débil teoría económica y mayor desarrollo sobre historia de las ideas. A partir de 1964, con la publicación de La civilización del occidente medieval, se produce un cambio. Ese cambio se inscribe en una nueva orientación general de la escuela de Annales: el estudio de las mentalidades. Le Goff pretende realizar un análisis de la mentalidad del hombre medieval. Su estudio se basa principalmente en textos eruditos eclesiásticos. Se demuestra en este artículo que ese tipo de fuentes permiten acceder a la mentalidad de la parte sacerdotal de la clase de poder. De manera secundaria, Le Goff estudió fuentes literarias que permiten acercarse a la mentalidad de los caballeros. Para el análisis de los campesinos y de distintos sectores subalternos se necesitarían otro tipo de fuentes que nunca fueron utilizadas por Le Goff. Este análisis mantiene algunas semejanzas con el materialismo histórico, pero también tiene profundas diferencias con la doctrina de Marx. En base a esto se determina el alcance del legado de Le Goff

Compañeros de ruta, reencuentro de ex presos políticos cordobeses

El propósito de este trabajo es investigar los motivos, anhelos, sueños, deseos que llevan a un grupo de entre 20 y 25 ex presos políticos a reunirse semanalmente en el local del sindicato Luz y Fuerza, Córdoba. Optamos por entrevistar a quienes daban la sensación de ser más participativos o más explícitos, en la elección procuramos que hubiesen casi por igual miembros de las dos organizaciones mayoritarias en el pasado: Montoneros y Partido Revolucionario de los Trabajadores. El celo a la hora de elegir se entronca con las subculturas que emergieron de las organizaciones. Otro aspecto observado es la cuestión de género, mujeres y hombres, equitativamente incorporados, se constituyeron en narradores.2 En la ciudad mediterránea hubo alrededor de dos mil detenidos por causas políticas a partir de la dictadura que iniciara Jorge Rafael Videla. La curiosidad social es acicateada por el número exiguo de ex-represaliados que constituyen la comisión de presos políticos, que entre otras tareas peticiona ante las autoridades solicitando reivindicaciones a raíz de su condición de ex detenidos, organizan eventos sociales y políticos, gestionan los ex centros de detención convertidos en "museos de la memoria", impulsan los juicios contra los ex represores, editan publicaciones. Concurrimos a las reuniones semanales, a asados, "locreadas"; empleamos en las investigaciones la observación participante. La participación se dio en eventos, en compartir ruedas de mate en la casa de los entrevistados, íntimas ruedas de café, por un fenómeno de indexicalidad en relación con el discurso ideológico pudimos avanzar en la profundidad de la conversación. Además, de las entrevistas en profundidad, analizamos material periodístico y material escrito por los detenidos; cuando la emoción del entrevistado dificultaba la conversación, en algunos casos nos remitieron a elaboraciones suyas sobre la situación planteada.. Nos favoreció, en el trabajo, el hecho de haber participado en la vida política, y el tener familiares que lucharon junto a los ex-represaliados. A pesar de ello no fue fácil llegar a subjetividades que hacía largo tiempo se hallaban abroqueladas. Mead e Erving Goffman nos acompañaron en el camino de reconocimiento de los selfs en la dramaturgia montada en el local de Luz y Fuerza

Le Goff : Balance crítico de un legado

Los primeros trabajos de Jacques Le Goff, sobre mercaderes, banqueros e intelectuales de la Edad Media, presentan cualidades que anuncian su desarrollo posterior: débil teoría económica y mayor desarrollo sobre historia de las ideas. A partir de 1964, con la publicación de La civilización del occidente medieval, se produce un cambio. Ese cambio se inscribe en una nueva orientación general de la escuela de Annales: el estudio de las mentalidades. Le Goff pretende realizar un análisis de la mentalidad del hombre medieval. Su estudio se basa principalmente en textos eruditos eclesiásticos. Se demuestra en este artículo que ese tipo de fuentes permiten acceder a la mentalidad de la parte sacerdotal de la clase de poder. De manera secundaria, Le Goff estudió fuentes literarias que permiten acercarse a la mentalidad de los caballeros. Para el análisis de los campesinos y de distintos sectores subalternos se necesitarían otro tipo de fuentes que nunca fueron utilizadas por Le Goff. Este análisis mantiene algunas semejanzas con el materialismo histórico, pero también tiene profundas diferencias con la doctrina de Marx. En base a esto se determina el alcance del legado de Le Goff

Late Miocene to Holocene calcareous nannofossils from ODP sites of Leg 125

During Leg 125 of the Ocean Drilling Program, nine sites were drilled in the Mariana and Izu-Bonin areas. The sediments recovered range in age from early Pliocene to late Pleistocene in the Mariana Region and from middle Eocene to late Pleistocene in the Izu-Bonin region. This contribution concerns the biostratigraphic study of the latest Miocene (CN9b Subzone) to late Pleistocene interval. Aquantitative analysis of all calcareous nannofossil associations was conducted for the interval encompassing late Miocene to the top of the early Pliocene. Moreover, the genera Discoaster, Amaurolithus, and Ceratolithus were quantitatively investigated from the late Miocene to late Pliocene interval. Some bioevents were identified, and variations in the composition of assemblages were linked to climatic changes.

Early Cretaceous palynomorphes from ODP Hole 113-692B

Detailed descriptions of in situ ?Valanginian to Albian Antarctic palynofloras are presented from Weddell Sea claystones with high percentages of organic matter ("black shales") and intercalated volcanic ash layers. The claystones were recovered from two sites (ODP Leg 113, Sites 692 and 693) on the continental margin of Dronning Maud Land. Palynological investigations of these Cretaceous sediments revealed a ?Valanginian-Hauterivian age for the Site 692 sediments and an Aptian-Albian age for Site 693. This paper is focused on the palynomorphs of Site 692. Miospores, dinoflagellate cysts, and acritarchs are listed and compared with early Cretaceous microfloras from the Antarctic Peninsula, Australia, and South America. The dinocyst assemblage of Site 692 seems to be very similar in composition to an assemblage from the South Shetlands (?Valanginian-Hauterivian-Barremian). It also agrees well with associations described from early Early Cretaceous sequences from the Perth Basin, southwestern Australia. According to the Australian miospore zonation schemes, the sporomorph flora from Site 692 belongs to the South Australian Foraminisporis wonthaggiensis Zone (early Valanginian to Hauterivian) or the lower part of the dinocyst Muderongia Superzone (Valanginian to Hauterivian).

Paleogene and early Neogene stable isotope record of foraminifera from ODP Leg 119 samples

Oxygen and carbon isotopic records of monogeneric and monospecific benthic and planktonic foraminifer samples from Sites 744 and 738 drilled on the southern end of the Kerguelen Plateau during ODP Leg 119 reveal the evolution of polar Indian Ocean water masses from the early Paleocene to the middle Miocene. Results from Site 738 are from sediments of early Paleocene to late Eocene age and those from Site 744 are late Eocene to middle Miocene. They suggest that intermediate waters at this location did not originate in the high latitudes during the early Eocene. Surface and near-surface waters cooled gradually after the maximum warming at 56 Ma, when surface waters were about 18°C. Intermediate waters cooled after 52 Ma. The highest temperatures (lowest d18O values) of the Cenozoic occurred from 56 to 52 Ma. The records of equatorial Pacific Site 577 and Weddell Sea Site 690 resemble that of the polar Indian Ocean in this interval. The well-documented d13C excursions toward positive values in the late Paleocene and negative values in the early Eocene are represented by foraminifers increases of 1.5 per mil and following decreases of about 3 per mil. Most of the cooling in the Paleogene occurred in the middle and late Eocene. A 2°C decrease of surface water at about 38.4 Ma heralded the beginning of extensive glacial conditions in Antarctica in the early Oligocene. At Site 744, the global d18O shift just above the Eocene/Oligocene boundary is 1.15 per mil, and occurred gradually in sediments dated at 36.5-35.9 Ma. Ice-rafted debris was deposited beginning at 36.1 Ma for about the next 2 m.y. This simultaneous occurrence of the global d18O shift with ice-rafted debris is evidence for early Oligocene glaciation in East Antarctica. Moreover, early and late Oligocene Cibicidoides d18O values between 2 and 2.2 per mil indicate intermediate water cooling and a small ice-volume effect. Production of cold dense bottom water in Antarctica was intensified with continental cooling and glaciation in the early Oligocene. Comparison of Oligocene and early Miocene isotopic data from high-latitude and low-latitude deepsea sites indicates that there were probably at least two sources of bottom waters at this time.

Geochemistry and accumulation rates of the early Paleogene in the Weddel Sea, Maud Rise and Kerguelen Plateau

Marine biological productivity has been invoked as a possible climate driver during the early Paleogene through its potential influence on atmospheric carbon dioxide concentrations. However, the relationship of export productivity (the flux of organic carbon (C) from the surface ocean to the deep ocean) to organic C burial flux (the flux of organic C from the deep ocean that is buried in marine sediments) is not well understood. We examine the various components involved with atmosphere-to-ocean C transfer by reconstructing early Paleogene carbonate and silica production (using carbonate and silica mass accumulation rates (MARs)); export productivity (using biogenic barium (bio-Ba) MARs); organic C burial flux (using reactive phosphorus (P) MARs); redox conditions (using uranium and manganese contents); and the fraction of organic C buried relative to export productivity (using reactive P to bio-Ba ratios). Our investigations concentrate on Paleocene/Eocene sections of Sites 689/690 from Maud Rise and Site 738 from Kerguelen Plateau. In both regions, export productivity, organic C burial flux, and the fraction of organic C buried relative to export productivity decreased from the Paleocene/early Eocene to the middle Eocene. A shift is indicated from an early Paleogene two-gyre circulation in which nutrients were not efficiently recycled to the surface via upwelling in these regions, to a circulation more like the present day with efficient recycling of nutrients to the surface ocean. Export productivity was enhanced for Kerguelen Plateau relative to Maud Rise throughout the early Paleogene, possibly due to internal waves generated by the plateau regardless of gyre circulation.