Investigação de Leishmania SP em carrapatos de cães de bairros de Imperatriz-MA, através da Reação em Cadeia da Polimerase (PCR)

A Leishmaniose é uma doença causada pelo protozoário Leishmania sp, podendo acometer homem e animais dependendo da espécie do parasita, São transmitidos pelos flebotomíneos fêmeas, insetos do gênero Lutzomyia, que ao exercer o hematofagismo inoculam as formas promastigota infectantes, mas recentemente, tem sido levantado hipóteses sobre a transmissão por carrapatos. Segundo a vigilância epidemiológica de Imperatriz-MA a cidade é endêmica tanto para Leishmaniose Tegumentar (LT) quanto para a Leishmaniose Visceral (LV). Este trabalho teve como objetivo principal investigar a presença de DNA de Leishmania sp em carrapatos coletados de cães atendidos em petshop e Centro de Controle de Zoonoses do município de Imperatriz utilizando a técnica de PCR. O DNA foi extraído a partir de 640 carrapatos fêmeas e testadas utilizando o primer que amplifica o gene de mini-exon de Leishmania sp. Os carrapatos foram coletados de 41 cães de diferentes bairros da cidade de Imperatriz. A maioria dos carrapatos foram identificados como Rhipicephalus sanguineus. Os seguintes sinais clínicos sugestivos de leishmaniose foram observados nos cães: onicogrifose em 53,65% (22/41); úlceras em 63,41% (26/41), a perda de cabelo e inapetência em 39,02% (16/41). Cento e setenta carrapatos (26,56%) coletados de 16 cães apresentaram DNA de Leishmania do subgênero Viannia, responsável pela forma cutânea da doença. Não foi detectado nenhum DNA de Leishmania infantum chagasi. Carrapatos infectados foram coletados de ambos os cães sintomáticos e assintomáticos. Embora ainda não tenha sido demonstrado que os carrapatos possam transmitir Leishmania aos cães sob condições naturais, o resultado deste estudo tem vários aspectos importantes, pois é um método não-invasivo de detecção, capaz de diferenciar os grupos de parasitas em circulação, em especial se os animais não têm lesões, pode ser um indicador biológico em locais onde não é feito uma investigação sorológica e nem entomológica, podendo dar suporte aos programas de vigilância de saúde local.

Avaliação comparativa da eficácia da terapia de reposição hormonal de baixa dose isolada ou associada à sinvastatina no perfil lipídico e lipoprotéico em mulheres sintomáticas e dislipidêmicas na pós-menopausa

Pós-graduação em Ginecologia, Obstetrícia e Mastologia - FMB

Parâmetros fisiológicos de laranjeiras com Huanglongbing

Pós-graduação em Agronomia (Produção Vegetal) - FCAV

Caracterização de lesões desportivas no basquetebol

INTRODUCTION: Basketball is characterized with high injury rate. In the literature it's not defined whether or not there are differences between the sexes. OBJECTIVE: Characterize and analyze the incidence of athletic injuries in basketball players, comparing the sexes. MATERIALS AND METHODS: Fifteen under-23 category athletes of each sex were interviewed with the reported morbidity inquire. RESULTS: The age of the female and male teams, in average, was 18 ± 0.65 and 18.20 ± 1.57 years respectively. The male team had more injuries than the female one (respectively 2.6 ± 1.45 against 1.2 ± 1.18, p < 0.05). The joint damage was the most common injury in the male team, representing 58.97%, and the second most common in the female team (33.33%). The lower limbs were the most common injured sites (80.95% in the female and 69.23% in the male). The most frequent injury mechanism in the male team was the landing (43.59%), and in the female was the vertical jump (28.57%). In both teams the most injuries occurred during the training (61.9% in the female and 71.8% in the male). The absence was necessary in 47.62% (female) and 56.41% (male). Great part of the athletes didn't received any treatment (61.9% and 51.28% in the female and male team respectively). The return to the activities was mostly symptomatic, in both female and male team (85.71% and 84.62% respectively). CONCLUSION: The incidence of injuries in basketball is higher in the lower limbs. The male team is more likely to suffer injuries, and the main injury mechanisms were different between male and female team.

Uma análise dos efeitos do uso a longo prazo de antidepressivos

Pós-graduação em Psicologia - FCLAS

New treatment strategies for Alzheimer's disease: is there a hope?

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease, and corresponds to the most common cause of dementia worldwide. Although not fully understood, the pathophysiology of AD is largely represented by the neurotoxic events triggered by the beta-amyloid cascade and by cytoskeletal abnormalities subsequent to the hyperphosphorylation of microtubule-associated Tau protein in neurons. These processes lead respectively to the formation of neuritic plaques and neurofibrillary tangles, which are the pathological hallmarks of the disease. Clinical benefits of the available pharmacological treatment for AD with antidementia drugs (namely cholinesterase inhibitors and memantine) are unquestionable, although limited to a temporary, symptomatic support to cognitive and related functions. Over the past decade, substantial funding and research have been dedicated to the search and development of new pharmaceutical compounds with disease-modifying properties. The rationale of such approach is that by tackling key pathological processes in AD it may be possible to attenuate or even change its natural history. In the present review, we summarize the available evidence on the new therapeutic approaches that target amyloid and Tau pathology in AD, focusing on pharmaceutical compounds undergoing phase 2 and phase 3 randomized controlled trials.

The role of IL-6 on apical periodontitis: a systematic review

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Do people with recurrent back pain constrain spinal motion during seated horizontal and downward reaching?

Background: Although the effect of symptomatic back pain on functional movement has been investigated, changes to spinal movement patterns in essentially pain-free people with a history of recurrent back pain are largely unreported. Reaching activities, important for everyday and occupational function, often present problems to such people, but have not been considered in this population. The purpose of this study was to compare the amplitude and timing of spinal and hip motions during two, seated reaching activities in people with and without a history of recurrent low back pain (RLBP).Methods: Spinal and hip motions during reaching downward and across the body, in both directions, were tracked using electromagnetic sensors. Analyses were conducted to explore the amplitudes, velocities and timings of 3D segmental movements and to compare controls with subjects with recurrent, but asymptomatic lumbar or lumbosacral pain.Findings: We detected significant differences in the amplitude and timing of movement in the lower thoracic region, with the RLBP group restricting movement and demonstrating compensatory increased motion at the hip. The lumbar region displayed no significant between-group differences. The order in which the spinal segments achieved peak velocity in cross-reaching was reversed in RLBP compared to controls, with lumbar motion leading in controls and lagging in RLBP.Interpretation: Subjects with a history of RLBP show a number of altered kinematic features during reaching activities which are not related to the presence or intensity of pain, but which suggest adaptive changes to movement control. (C) 2013 Elsevier Ltd. All rights reserved.

Serological and infection statuses of dogs from a visceral leishmaniasis-endemic area

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Identification and sequence analysis of five allexiviruses species infecting garlic crops in Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Indícios de subjetividade na fala de uma criança psicótica: um olhar para as hesitações

This study, performed under a linguistic-discoursive prism, aimed to: (1) describe the moments in which occurred hesitations in the utterances of a psychotic child diagnosed with Language Disorder; and (2) determine the extent to which these moments (also) can indicate aspects of a subjectivity trying to emerge in this child. Data were extracted from a speech therapy session with a ten year old female child. Concerning the fi rst goal, from a total of 362 utterances produced by the child, only 74 (20%) had hesitation traces, while 288 (80%) did not. Concerning the second goal, the utterances with hesitation traces occurred in situations of: topic development, especially in the form of complementarity; introduction of new topic; return to the previous topic; refuses to the topic; enunciative incompleteness. The high percentage of utterances without hesitation traces (80%) is explained because they are highly predictable from the context, mostly in situations of ritualized adjacent pairs, oftentimes in situations of immediate specularity. The reduced percentage of utterances with hesitation traces are explained precisely by the fact that, unlike those without traces, in these ones, signs of a subjectivity that tries to emerge and show itself in the discourse production are detected. With the development of this study, we tried to emphasize the view at the hesitations as marks of subjectivity – in other words, evidences of confl icting relationships between the subject and the others that constitute the utter. The concern was also about bringing to the fi eld of Speech Pathology discoursive linguistic refl ections based on data extracted from symptomatic contexts of language.

Incidência e Caracterização de Lesões Desportivas no Taekwondo segundo o Gênero

Taekwondo practice has been associated with physical and biomechanical overloads, which are related to occurrence of sports injuries (SI). However, etiological and nosographic information about SI are limited and conflicting. This study analyzed and characterized the SI in Taekwondo athletes, according to gender. Casuistic integrated 22 athletes, 12 men and 10 women, athletes from São Paulo State Team of Taekwondo, adult category, with 23,6±6,8 years, body weight of 66,0±13,1 kg and 1,72±0,09 m of height. Reported morbidity survey was used to obtain retroactive information to 2009 season. Nosographic variables were analyzed using Goodman’s Test for contrasts among multinomial populations. All athletes reported injuries in the season; 56 cases were registered, determining an injury rate of 2.54 SI/athlete; 26 events (46.4%) occurred in males (2.17 SI/athlete), and 30 (53.6%) were related to women (3.00 SI/athlete). There were predominance of injuries in joints (35,7%) and muscles (39,3%); both genders presented injuries in lower members (82.1%, p<0.01), predominant in combat situations (80.4%, p<0.05), during the preparatory period of training (73.2%). There was a higher treatment request among male athletes (73.1%), which showed high asymptomatic return (69.2%); the female group referred similar proportions of absence and presence of treatment request, collaborating for the greater symptomatic return of these athletes (70.0%). In conclusion, the results support predominance of muscles and joints injuries in lower segments, derived from fighting, involving female athletes.

Caracterização das lesões desportivas em atletas de Tênis de Mesa

Introduction: The table tennis is characterized by requiring of the athletes intense body movement. The gestures performed by athletes require continuous postural changes, in cases of any sway in body structures may produce postural changes or initiate processes of injuries. Objective: The aim of this study was to characterize the table tennis lesions. Method: Were evaluated 31 athletes (26 males and fi ve females) with mean age 22.35±6.67 years. The subjects were interviewed with the Reported Morbidity Inquires retroactive to the 2009 season. It was used techniques of descriptive and analytical statistics. Results: The largest number of injuries was muscular (74.35%), on the shoulder (43.58%) during the movement of top spin (33.33%) in the specifi c training phase (64.1%) with symptomatic return to the activities (69.23%). Conclusion: The weekly training workload infl uences the number of lesions.

Changes in heart period during endodontic treatment

Background: Tooh extraction was demonstrated to increase sympathetic modulation of the heart, however, it is not understood the effects of endodontic treatment on cardiac autonomic regulation. We evaluated heart rate variability (HRV) during endodontic treatment. Method: 50 male and female patients aged between 18 and 40 years old and diagnosed with irreversible pulpitis or pulp necrosis of the lower molars with indication of gender endodontic treatment were analyzed. HRV was analyzed in the time (SDNN, RMSSD, pNN50) and frequency (LF, HF and LF/HF ratio) domains recorded in the first session of root canal treatment. The indices were analyzed in the following periods: T1) ten minutes before the endodontic treatment, T2) ten minutes after the administration of anesthesia before endodontic treatment, T3) during the entire period of endodontic treatment and T4) thirty minutes after the end of the endodontic treatment. Results: The SDNN, RMSSD and pNN50 indices increased at T2 compared to T1, the pNN50 and RMSSD indices increased at T3 and T4 compared to T2. The LF in normalized units increased at T4 compared to T2 and in absolute units it was increased at T4 compared to T1. The HF in normalized units was reduced at T4 compared to T2 and in absolute units was reduced at T1, T3 and T4 compared to T2. The LF/HF ratio was higher at T4 compared to T2. Conclusion: The global modulation of heart increases after local anesthesia and vagal tone reduce during surgery procedures and after the surgical procedures.