1000 resultados para Sanderson, Robert, 1587-1663.
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Inscripción en al ángulo inferior derecho: "1er. Volume"
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Durante el verano de 2013 Manhattan albergó las muestras de dos artistas que trabajan con la luz y el espacio: una amplia exposición retrospectiva de James Turrell en el Museo Guggenheim y una instalación de Robert Irwin para el Museo Withney de Arte Americano. Ambos han hecho de la percepción el elemento fundamental de sus obras en una investigación que comenzó en los años sesenta y que han continuado desarrollando a lo largo de los últimos cuarenta y cinco años. Los dos compartieron en sus comienzos una línea de investigación conjunta, sis investigaciones sobre las sensaciones en el espacio y su estudio empírico fueron cruciales para el desarrollo de sus obras que hacen de la experiencia espacial un mecanismo de trascendencia. Sus trabajos son de gran interés para la arquitectura poarque los dos hacen de la percepción en el espacio el argumento fundamental de su investigación artística.
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The period between 1570-1620 has left a remarkable amount of documents related to shipbuilding in the Iberian Peninsula. Among them, the Instrucción nautica written by Diego García de Palacio in 1587 is widely recognized as the first published book that includes an extensive discussion of ship design and construction. García de Palacio centres his discussion on a 400 toneladas nao, a series of woodcuts that illustrate the shape and dimensions of the ship accompany the explanation. In the late XVI century ship hulls were designed following procedures based upon an old shipwrightry tradition born in the Mediterranean. By simple rules the master shipwright plots the central frame and tail frames and complete the hull body using wooden ribbands. Computer software for 3D modelling using NURBs surfaces helps to recreate ships hulls. In this work the 400 toneladas nao is reconstructed and her hydrostatic parameters are compared with other ships.
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Hay un ejemplar encuadernado con: Synodus oriolana secunda (XVI/96).
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Nonpathogenic, resident bacteria participate in the pathogenesis of inflammation in the small intestine, but the molecular messages produced by such bacteria are unknown. Inflammatory responses involve the recruitment of specific leukocyte subsets. We, therefore, hypothesized that butyrate, a normal bacterial metabolite, may modulate chemokine secretion by epithelial cells, by amplifying their response to proinflammatory signals. We studied the expression of the chemokine, macrophage inflammatory protein-2 (MIP-2) by the rat small intestinal epithelial cell line, IEC-6. Cells were stimulated with lipopolysaccharide or with interleukin 1β (IL-1β) and incubated with sodium butyrate. Acetylation of histones was examined in Triton X acetic acid–urea gels by PAGE. Unstimulated IEC-6 cells did not secrete MIP-2. However, lipopolysaccharide and IL-1β induced MIP-2 expression. Butyrate enhanced MIP-2 secretion both in lipopolysaccharide-stimulated and IL-1β-stimulated enterocytes; but butyrate alone did not induce MIP-2 expression. Butyrate increased the acetylation of histones extracted from the nuclei of IEC-6 cells. Furthermore, acetylation of histones (induced by trichostatin A, a specific inhibitor of histone deacetylase) enhanced MIP-2 expression by cells stimulated with IL-1β. In conclusion, trichostatin A reproduced the effects of butyrate on MIP-2 secretion. Butyrate, therefore, increases MIP-2 secretion in stimulated cells by increasing histone acetylation. We speculate that butyrate carries information from bacteria to epithelial cells. Epithelial cells transduce this signal through histone deacetylase, modulating the secretion of chemokines.
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Inclui notas explicativas, bibliográficas e bibliografia
