[Rome. Chiesa di San Gregorio Magno]

Référence bibliographique : Weigert, 516

[Rome. Basilica di San Lorenzo fuori le mura]

Référence bibliographique : Weigert, 527

[Rome. Basilica di San Lorenzo fuori le mura]

Référence bibliographique : Weigert, 528

[Rome. Basilica di San Lorenzo fuori le mura]

Référence bibliographique : Weigert, 529

[Rome. Basilica di San Lorenzo fuori le mura]

Référence bibliographique : Weigert, 530

[Rome. Basilica di Santa Maria in Aracoeli]

Référence bibliographique : Weigert, 507

[Rome. Basilica di Santa Maria in Aracoeli]

Référence bibliographique : Weigert, 549

[Rome. Basilica di Santa Maria in Domnica]

Référence bibliographique : Weigert, 551

[Rome. Chiesa di Santa Maria di Loreto]

Référence bibliographique : Weigert, 550

[Rome. Basilica di Santa Maria Maggiore]

Référence bibliographique : Weigert, 552

Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission.

Synaptic transmission depends critically on the Sec1p/Munc18 protein Munc18-1, but it is unclear whether Munc18-1 primarily operates as a integral part of the fusion machinery or has a more upstream role in fusion complex assembly. Here, we show that point mutations in Munc18-1 that interfere with binding to the free Syntaxin1a N-terminus and strongly impair binding to assembled SNARE complexes all support normal docking, priming and fusion of synaptic vesicles, and normal synaptic plasticity in munc18-1 null mutant neurons. These data support a prevailing role of Munc18-1 before/during SNARE-complex assembly, while its continued association to assembled SNARE complexes is dispensable for synaptic transmission.

[Rome. Grotta di Egeria, dite aussi Aqua Farella]

Référence bibliographique : Weigert, 556-557

[Rome. Chiesa di Sant'Urbano alla Caffarella]

Référence bibliographique : Weigert, 543

[Rome. Cenotafio di Annia Regilla]

Référence bibliographique : Weigert, 595