Portrait of Gretel Soudek nee Heimann Portraits Women

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Studio portrait of Gretel Heimann (on right) with her sister Anna Portraits Children

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Nachum Glatzer studying Torah Portraits Men

Signed by photographer lower right

New genetic loci link adipose and insulin biology to body fat distribution

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10−8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Signed portrait of Gretel Soudek nee Heimann Portraits Women

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Studio portrait of Josef Soudek as a young boy dressed in a sailor suit; Bodenbach (Děčín, Czech Republic) Portraits Children

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Portrait of the Vienna physician Dr. Friedrich Foerster Portraits Men

Photograph found in book donated to LBI library by Alex Natan (AR 11349)

Miriam Levin, neice of Dr. Friedrich Foerster, with her husband Dr. J. Levin Portraits Couples

Photograph found in book donated to LBI library by Alex Natan (AR 11349)

Reiss family portrait; (l-r) Olga, Herbert, Flora Lotte, Walter, Moritz and Kurt; Saaz, Czechoslovakia Portraits Family

Olga Reiss nee Kohn died 1950s; Herbert Reiss, 1905-circa 1980; Flora Lotte "Lola" Reiss, 1910-1995; Walter Reiss, 1908-1937; Moritz Reiss, 1876-1965; Kurt Reiss, 1906-1996

Portrait of Walter Reiss in uniform Portraits Men

Walter Reiss, 1908-1937

Photo identification portrait of Walter Reiss Portraits Men

Walter Reiss, 1908-1937

Studio portrait of Josef Reiss(?); Saaz, Czechosolvakia Portraits Men

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Portrait of Moritz Reiss in uniform taken by the Imperial photographer; Vienna Portraits Men

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Portrait of Moritz and Olga Reiss Portraits Couples

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Portrait of Olga Reiss nee Kohn Portraits Women

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