N-acetylcysteine versus placebo for treating nail biting, a double blind randomized placebo controlled clinical trial

Nail biting is a common behavioral problem. While there are established behavioral interventions for management, they are of modest efficacy, and there is minimal evidence for effective pharmacotherapy. This study investigated the role of N-acetylcysteine (NAC) a potent glutathione and glutamate modulator for the treatment of pathological nail biting in children and adolescents. This pilot randomized, double-blind, placebo-controlled clinical trial of NAC (800mg/day) or placebo enrolled 42 children and adolescents with chronic nail biting. Nail length was the objective outcome. Evaluations were carried out three times; before treatment, one month after enrollment in the study, and two months after enrollment. The duration (chronicity) of nail biting in the NAC and placebo groups was 3.63(2.45) and 5.09(3.74) years (P=0.14). The mean nail length gradually increased in both the NAC and placebo groups during this trial. There was a statistically significant difference between the two groups regarding increased nail length after the first month of trial [(5.21(5.75) and 1.18(3.02) millimeters], however no difference after two months was observed. Two patients in the NAC group discontinued medication due to adverse events. One patient experienced headache, agitation, and social withdrawal, and another patient expressed severe aggression after taking medication and was withdrawn from the study. This study supports the hypothesis that NAC decreases nail biting behavior in children and adolescents over the short term. NAC is relatively well tolerated and severe adverse effects are rare. However, there was a high rate of dropout. Further studies with longer durations that build on these preliminary data are recommended.

Advanced science and technology letters : advanced researches on security and assurance

We would like to welcome you to the Regular Papers proceedings of the 7th International Conference on Information Security and Assurance (ISA 2013) which was held on April 26-28, 2013 at Waterfront Airport Hotel and Casino, Cebu, Philippines. ISA 2013 is focused on various aspects of advances in researches on Security and Assurance. It provided a chance for academic and industry professionals to discuss recent progress in the related areas. We expect that the conference and its publications will be a trigger for further related research and technology improvements in this important subject. We would like to acknowledge the great effort of all the Chairs and members of the Editorial Committee. We would like to express our gratitude to all of the authors of submitted papers and to all attendees, for their contributions and participation. We believe in the need for continuing this undertaking in the future.

A cross-disciplinary analysis of thematic structure of dissertation abstracts

The ways by which the academic texts are investigated differ from time to time with legacies of each tradition influencing the subsequent approaches. One of the approaches that has not lost its favor ever since it was established is the Australian Systemic Functional tradition. Based on the descriptions provided by this tradition, in this study, the thematic structure (Halliday, 1994) of the gap indication move and the Introduction section (Swales, 2004) of 120 dissertation abstracts from six disciplines was investigated at two levels, i.e. choice of theme type and thematic progression. The simple topical theme was recognized as the typical theme of the rhetorical units in focus across the six disciplines. With respect to the thematic progression, the theme-reiteration and zig-zag patterns were found to be the characteristic patterns. These results indicate that the language of abstracts is remarkably factual and far from abstraction.

Comparative study of routing protocols for opportunistic networks

Opportunistic networks or OppNets refer to a number of wireless nodes opportunistically communicating with each other in a form of “Store-Carry-Forward”. This occurs when they come into contact with each other without proper network infrastructure. In OppNets there is no end-to-end connection between the source node and the destination node. OppNets grow from a single node (seed) to become large networks by inviting new nodes (helpers) to join the network. Due to these characteristics, OppNets are subject to real routing challenges. In this paper, we have presented an overview of the main available three families of OppNet routing protocols. Further, we have evaluated one protocol from each family (Epidemic, Direct Delivery and PRoPHET) in terms of complexity and scalability. Simulation results show that for small and medium complexity, the three protocols perform better than large complexity. As for scalability, simulation results show that Epidemic and PRoPHET perform better than Direct Delivery in terms of delivery rates and delays, but at a very high cost while Direct Delivery achieved lower delivery rates with a low cost.

A cross-disciplinary analysis of rhetorical structure of dissertation abstracts

The teaching rhetorical structure of various academic genres has been recognized as a practical, pedagogical tool in both ESL and EFL academic settings. However, assigning a unitary structure for different fields of study might poses problems for novice writers. In this study, the rhetorical structure of 120 abstracts (ninety ‘masters’ theses and thirty ‘doctoral’ dissertations) from six disciplines were investigated. In this exploratory study, four rhetorical structures were found: IMRC/D, CARS, Mixed, and None (which means the texts lack any rhetorical structure). The conclusion is that nonnative speakers require more than grammatical knowledge at the clause level. They need to be familiarized with the discourse grammar with the functional tokens attached to it in order to be successful in their academic writing.

Economic effects of the external debt crisis for Pakistan

Pakistan experienced an external debt crisis in 1998. There is robust evidence of the significant positive effects of the growth rate of real long-term external debt and negative effects of the growth rate of total debt servicing as a percentage of exports on real GDP growth in short and long-run.