ICGE: an R package for detecting relevant clusters and atypical units in gene expression

Background: Gene expression technologies have opened up new ways to diagnose and treat cancer and other diseases. Clustering algorithms are a useful approach with which to analyze genome expression data. They attempt to partition the genes into groups exhibiting similar patterns of variation in expression level. An important problem associated with gene classification is to discern whether the clustering process can find a relevant partition as well as the identification of new genes classes. There are two key aspects to classification: the estimation of the number of clusters, and the decision as to whether a new unit (gene, tumor sample ... ) belongs to one of these previously identified clusters or to a new group. Results: ICGE is a user-friendly R package which provides many functions related to this problem: identify the number of clusters using mixed variables, usually found by applied biomedical researchers; detect whether the data have a cluster structure; identify whether a new unit belongs to one of the pre-identified clusters or to a novel group, and classify new units into the corresponding cluster. The functions in the ICGE package are accompanied by help files and easy examples to facilitate its use. Conclusions: We demonstrate the utility of ICGE by analyzing simulated and real data sets. The results show that ICGE could be very useful to a broad research community.

Kalman Filtering in R

Support in R for state space estimation via Kalman filtering was limited to one package, until fairly recently. In the last five years, the situation has changed with no less than four additional packages offering general implementations of the Kalman filter, including in some cases smoothing, simulation smoothing and other functionality. This paper reviews some of the offerings in R to help the prospective user to make an informed choice.

Cartas enviadas por Julio Altadill a Justo Garate entre 1929 y 1931

3 cartas (manuscritas) ; entre 210x265mm y 161x222mm. Ubicación: Caja 1 - Carpeta 23

Cartas enviadas por Telesforo de Aranzadi a Justo Garate entre 1929 y 1932

8 cartas (manuscritas) y 1 carta (manuscrita y mecanografiada) ; entre 160x180mm y 320x200mm. Ubicación: Caja 1 - Carpeta 40

Cartas enviadas por Francisco R. de Arbulu a Justo Garate en 1970

12 cartas y 2 notas (manuscritas) ; entre 160x215mm y 240x350mm. Ubicación: Caja 1 - Carpeta 41

Cartas enviadas por Francisco R. de Arbulu a Justo Garate entre 1972 y 1973

12 cartas (manuscritas) ; entre 215x230mm y 210x2970mm. Ubicación: Caja 1 - Carpeta 41

Alvará de declaração com força de Lei, pelo qual V.A.R. ha por bem ordenar, que os Ministros, quando despacharem o levantamento dos depositos feitos no Banco Nacional, o fação por precatorios expedidos na conformidade do que se acha determinado para a Junta da Administração dos depositos de Lisboa no Alvará de seis de julho de mil setecentos cincoenta e quatro, na forma acima exposta : para Vossa Alteza Real ver

Variação do Título : Obrigação de precatorias para levantamento de depositos no Banco do Brasil.

Alvará, pelo qual V.A.R. ha por bem estabelecer hum methodo de Thesourarias Geraes para o Exercito, em que se reuna exactidão na fiscalização da Fazenda Real como prompto pagamento das tropas, extinguindo as Thesourarias, e Pagadorias, que agora existem, tudo como acima se declara : para Vossa Alteza Real ver

Variação do Título : Regulamento das Tesourarias Gerais do Exercito.

Tarjeta enviada por R. Azkue a Justo Garate en 1925

1 tarjeta (manuscrita) ; 136x92mm. Ubicación: Caja 1 - Carpeta 83

Synopse dos trabalhos da Camara dos Srs. Deputados : relativos ao anno de 1929 : acompanhados de differentes documentos : organizada na Secretaria da mesma Camara

Sinopse dos trabalhos da Câmara dos Deputados, em 1929.

Toxicity of Gramoxone super(R) and detergent to nile tilapia (Oreochromis niloticus) L. fingerlings

Acute toxicity tests on the effects of Gramoxone and detergent (both applied as a single dose) to nile tilapia, Oreochromis niloticus, fingerlings (mean weight 2.7~c1 g) were conducted using static bioassay. The 96-h LC sub(50) of Gramoxone and detergent applied were 0.08ml/l and 0.004 g/l, respectively. The fingerlings showed increased hyperactivities exemplified by erratic movement, loss of reflex, and hyperventilation during the period of exposure. These effects increased with increasing concentrations of Gramoxone or detergent throughout the duration of exposure. Tilapia fingerlings of the same size showed different levels of tolerance to the same concentration of both pollutants

Diagonal forms, linear algebraic methods and Ramsey-type problems

This thesis focuses mainly on linear algebraic aspects of combinatorics. Let N_t(H) be an incidence matrix with edges versus all subhypergraphs of a complete hypergraph that are isomorphic to H. Richard M. Wilson and the author find the general formula for the Smith normal form or diagonal form of N_t(H) for all simple graphs H and for a very general class of t-uniform hypergraphs H.

As a continuation, the author determines the formula for diagonal forms of integer matrices obtained from other combinatorial structures, including incidence matrices for subgraphs of a complete bipartite graph and inclusion matrices for multisets.

One major application of diagonal forms is in zero-sum Ramsey theory. For instance, Caro's results in zero-sum Ramsey numbers for graphs and Caro and Yuster's results in zero-sum bipartite Ramsey numbers can be reproduced. These results are further generalized to t-uniform hypergraphs. Other applications include signed bipartite graph designs.

Research results on some other problems are also included in this thesis, such as a Ramsey-type problem on equipartitions, Hartman's conjecture on large sets of designs and a matroid theory problem proposed by Welsh.

Carta enviada por Barbado a Justo Garate en 1929

1 carta (mecanografiada) ; 320x205mm.