931 resultados para Jerome, David Howell, 1829-1896
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verf. von Benedikt Foges
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The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.
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Nir Daṿid likhvod ha-rav he-ḥakham R. Daṿid Simonsen
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hrsg. von Simon Eppenstein ...
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von Max Landsberg
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ed. by Kaufmann Kohler. A biographical essay by Kaufmann Kohler. A memorial oration by Emil G. Hirsch
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Moses Bensabat Amzalak
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von David Kaufmann
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deciphered by L. Loewe
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Breslau, Univ., Diss., 1866
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von Nathan Bamberger