Iowa's 5 Percent Safety Report, 2006

A report of Iowa's top 5 percent of locations with the most severe safety needs, as required by the most recent federal highway reauthorization bill.

IoWoman September/October 2006, Vol.36, no.5

Newsletter for the Iowa Commission on the Status of Women

Puhemies Rafael Paasio 19/5 1966

Kirje

Kirjailija Ilmari Kianto 28/5 1966

Kirje 28.5.1966

Till Herr Chefredaktören 13.5.1973

Kirje

Förlagsdirektör Erik Westerberg 2/5 1967

Kirje 2.5.1967

Ellen Niemelä-Pylkkänen 5/4 1975

Kirje 5.4.1975

[Tasavallan Presidentin virallinen vierailu Saksan Liittotasavaltaan 6.5.-9.5.1979] (tasavallan presidentti Urho Kekkosen vastaus liittokansleri Helmut Schmidtin lounaalla pitämään puheeseen Bonnissa 8.5.1979)

Puhe

The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system.

Inositol Inpp5k (or Pps, SKIP) is a member of the inositol polyphosphate 5-phosphatases family with a poorly characterized function in vivo. In this study, we explored the function of this inositol 5-phosphatase in mice and cells overexpressing the 42-kDa mouse Inpp5k protein. Inpp5k transgenic mice present defects in water metabolism characterized by a reduced plasma osmolality at baseline, a delayed urinary water excretion following a water load, and an increased acute response to vasopressin. These defects are associated with the expression of the Inpp5k transgene in renal collecting ducts and with alterations in the arginine vasopressin/aquaporin-2 signalling pathway in this tubular segment. Analysis in a mouse collecting duct mCCD cell line revealed that Inpp5k overexpression leads to increased expression of the arginine vasopressin receptor type 2 and increased cAMP response to arginine vasopressin, providing a basis for increased aquaporin-2 expression and plasma membrane localization with increased osmotically induced water transport. Altogether, our results indicate that Inpp5k 5-phosphatase is important for the control of the arginine vasopressin/aquaporin-2 signalling pathway and water transport in kidney collecting ducts.