The Common Security and Defence Policy: National Perspectives. Egmont Paper No. 79, May 2015

FOREWORD. When one looks at the present state of the CSDP, one cannot help but look on with disenchantment at the energy that appears to have abandoned both institutions and Member States. Commentators increasingly take for granted that nothing much should be expected from this field of EU policy. The reasons for this state of mind are well known: the recent economic and financial strains, which have impacted all EU action since 2008, means that most of the Member States will struggle to keep their defence budgets at their present level in the future, and we may even see reductions. Furthermore, and to put it mildly, most of the recent CSDP operations have also experienced a lack of enthusiasm. Adding to this overall trend, the EU is far from presenting a common vision of what security and defence should really mean. Many of the Member States do not want to be involved in all of today’s international turmoils, and they rarely share the strategic culture which inspires those Member States who see themselves as having special responsibilities in dealing with these crises. In the end it may be that Member States diverge fundamentally on the simple question of whether it is relevant for the EU to engage in most of the ‘hot’ crises Europe faces; many prefer to see Europe as a soft power, mostly dedicated to intervening on less dramatic fronts and more inclined to mend than to fight. For whatever reason given, it remains that if there is a lack of common understanding on what CSDP should really be about, it should not come as a surprise if this policy is presently in stalemate. As an additional blow, the Ukrainian crisis, which dragged on for the whole of last year, could only add to the downward spiral the EU has been experiencing, with a new Russia aggressively confronting Europe in a manner not too distant from the Cold War days. This attitude has triggered the natural reaction among EU Member States to seek reassurances from NATO about their own national security. Coupled with the return of France a few years ago into the integrated military command, NATO’s renewed relevance has sent a strong message to Europe about the military organisation’s credibility with regard to collective defence. Surprisingly, this overall trend was gathering momentum at the same time as other more positive developments. The European Council of December 2013 dedicated its main session to CSDP: it underlined Europe’s role as a ‘security provider’ while adopting a very ambitious road map for Europe in all possible dimensions of the security sector. Hence the impression of a genuine boost to all EU institutions, which have been invited to join efforts and give CSDP a reinvigorated efficiency. In the same way, the increasing instability in Europe’s neighbourhood has also called for more EU operations: most recently in Iraq, Libya, Northern Nigeria or South Sudan. Pressure for further EU engagement has been one of the most constant features of the discussions taking place around these crises. Moreover, a growing number of EU partners in Asia, Latin America or Eastern Europe have shown a renewed eagerness to join CSDP missions in what sounds like a vote of confidence for EU capacities. What kind of conclusion should be drawn from this contradictory situation? Probably that the EU has much more potential than it can sometimes figure out itself, if only it would be ready to adapt to the new global realities. But, more than anything else, an enhanced CSDP needs from all Member States strong political will and a clear vision of what they want this policy to be. Without this indispensable ingredient CSDP may continue to run its course, as it does today. It may even grow in efficiency but it will keep lacking the one resource that would definitely help it overcome all the present shortcomings that have prevented Europe from finding its true role and mission through the CSDP. Member States remain central to EU security and defence policy. This is why this collection of essays is so valuable for assessing in no uncertain way the long road that lies ahead for any progress to be made. Pierre VIMONT Senior Associate at Carnegie Europe Former Executive Secretary-General of the European External Action Service

A perceção sobre a solidão e qualidade de vida no envelhecimento: impacto de um projeto de animação sociocultural

A alteração demográfica característica deste século e a desertificação do interior, em detrimento de grandes meios urbanos, no litoral, tem levado a que a população seja maioritariamente idosa e isolada. A falta de perspectiva, valorização pessoal e mesmo objectivos de vida conduzem à solidão, constituindo-se um dos principais problemas dos dias de hoje, com repercussões a nível social e económico. Este trabalho surge exactamente nesse sentido, constituindo-se numa forma de modificar atitudes e comportamentos dos idosos, tornando-os, dentro das limitações e gostos individuais, mais ativos e, tendencialmente, menos sedentários. Com o tema: A percepção sobre a solidão e qualidade de vida no envelhecimento: impacto de um projeto de animação sociocultural, tem como objectivo conhecer o impacto de um plano de actividades de animação sociocultural, na perceção sobre a solidão e qualidade de vida de vida de um grupo de pessoas com mais 65 anos. O trabalho apresentado está estruturado em três partes: enquadramento conceptual, metodologia e apresentação e discussão dos resultados, onde se identificam os dados da solidão como barreira limitativa e as condicionantes que provoca aos diferentes níveis na qualidade de vida do indivíduo. Através de uma série de atividades de animação sociocultural, com carácter lúdico e informal, propõe-se despertar os idosos para as vantagens de uma socialização mais ativa, como forma de estímulo também a nível cognitivo. Relativamente à metodologia do trabalho, optou-se por uma recolha de dados fidedigna através da versão portuguesa da Escala de Solidão da UCLA e pela versão portuguesa do WHOQOL-100 sendo o trabalho centrado no estudo da evolução destas variáveis nos idosos, antes e depois das actividades. O grupo estudado é constituído por catorze reformados, residentes no concelho de Portalegre, com idades compreendidas entre os 63 e os 83 anos, de ambos os géneros, e com escolaridade que varia entre a 4ª ano do ensino básico e o ensino superior, permitindo uma abordagem abrangente. Relativamente aos domínios da qualidade de vida foram encontrados valores superiores em todos os domínios, na avaliação efectuada após as atividades, sendo essas diferenças estatisticamente significativas em todos os domínios excepto no Domínio Psicológico. Na variável solidão foram encontrados valores superiores de percepção da solidão após a realização das atividades embora essa diferença não seja estatisticamente significativa. Relativamente aos resultados informais, percebeu-se que todo o grupo mostrou interesse em participar nas atividades de carácter cultural e social propostas, referindo nos seus próprios depoimentos a vontade de continuar, reconhecendo as diferenças no seu próprio comportamento e as significativas melhorias nas suas vivências e de relação com o outro, atribuindo outra visão ao seu tempo livre e participação ativa num envelhecimento que reconheceram como “mais saudável”.

Urinary Biomarkers Indicative of Apoptosis and Acute Kidney Injury in the Critically Ill.

BACKGROUND Apoptosis is a key mechanism involved in ischemic acute kidney injury (AKI), but its role in septic AKI is controversial. Biomarkers indicative of apoptosis could potentially detect developing AKI prior to its clinical diagnosis. METHODS As a part of the multicenter, observational FINNAKI study, we performed a pilot study among critically ill patients who developed AKI (n = 30) matched to critically ill patients without AKI (n = 30). We explored the urine and plasma levels of cytokeratin-18 neoepitope M30 (CK-18 M30), cell-free DNA, and heat shock protein 70 (HSP70) at intensive care unit (ICU) admission and 24h thereafter, before the clinical diagnosis of AKI defined by the Kidney Disease: Improving Global Outcomes -creatinine and urine output criteria. Furthermore, we performed a validation study in 197 consecutive patients in the FINNAKI cohort and analyzed the urine sample at ICU admission for CK-18 M30 levels. RESULTS In the pilot study, the urine or plasma levels of measured biomarkers at ICU admission, at 24h, or their maximum value did not differ significantly between AKI and non-AKI patients. Among 20 AKI patients without severe sepsis, the urine CK-18 M30 levels were significantly higher at 24h (median 116.0, IQR [32.3-233.0] U/L) than among those 20 patients who did not develop AKI (46.0 [0.0-54.0] U/L), P = 0.020. Neither urine cell-free DNA nor HSP70 levels significantly differed between AKI and non-AKI patients regardless of the presence of severe sepsis. In the validation study, urine CK-18 M30 level at ICU admission was not significantly higher among patients developing AKI compared to non-AKI patients regardless of the presence of severe sepsis or CKD. CONCLUSIONS Our findings do not support that apoptosis detected with CK-18 M30 level would be useful in assessing the development of AKI in the critically ill. Urine HSP or cell-free DNA levels did not differ between AKI and non-AKI patients.

Isoleucine epimerization in Quarternary planktic foraminifera of sediment core GIK12519-2, Sierra Leone Rise

Panktonic foraminiferal tests of the spinose species Orbulina universa, of the non-spinose Globorotalia tumida-menardii complex, and of a mixed species assemblage (grain size fraction 200-400 µm) were isolated from Sierra Leone Rise core GIK13519-2 and analyzed for free, total, and bound (by difference) amino acids to study the isoleucine epimerization mechanism in fossil foraminiferal tests and to define empirical calibration curves for dating deep-sea sediments over the past 900,000 years. Total isoleucine epimerization curves typically separate into three "linear" segments of decreasing apparents rates with increasing time and exhibit a pronounced "species effect". The degree of epimerization attained at time is considerably lower in O. universa than in G. tumida-menardii while the mixed species results scatter between the limits delineated by the two monospecific curves. Total allo/iso ratios are closely related to the proportion of free to total isoleucine accumulating in the tests indicating that the rate of hydrolysis of matrix proteins and peptides controls the overall epimerization reaction. The results are consistent with experimental evidenve where upon isoleucine epimerizes at a rapid rate in terminal positions but at slow rates in interior positions as well as in the free state. Notwithstanding free isoleucine exhibits the highest degree of epimerized terminal isoleucine. Species-specific hydrolysis and epimerization rates are maintained until about 50 % of bound isoleucine have been hydrolyzed to the free state corresponding to a total allo/iso ratio of about 0.5. Remaining peptide units appear to be more resistent against hydrolysis and separate species then show the same apparent epimerization rate dominantly controlled by the slow conversion rate in the free state until equilibrium is achieved in Miocene samples under deep-ocean temperature conditions. The degree of epimerization attained at comparable time in separate species will, however, remain different due to different initial rates of hydrolysis.

Asia and the Americas.

Mode of access: Internet.

365 desserts : a dessert for every day in the year : selected from Marion Harland, Mrs. Lincoln, Good housekeeping, Table talk, and others.

Recipes are organized by month; some recipes include wine or liquor as an ingredient. Sample recipes: Mock cantaloupe, Iced cocoa, Apple charlotte.

Foreign trade zones (FTZ's) [microform] : hearing before the Commerce, Consumer, and Monetary Affairs Subcommittee of the Committee on Government Operations, House of Representatives, One Hundred First Congress, first session, March 7, 1989.

CIS Microfiche Accession Numbers: CIS 89 H401-58

Bye-words; a collection of tales, new and old,

The boy bishop.--One will and three ways.--Kaspar's summer dream.--Buy a broom.--The travels of two kits.--Selma's secret sighs.--Our ghost at Fantford.--Anna's wedding cake.--Autobiography of Patty Applechecks.--A holiday engagement; or, The Campbells are coming.

The doctrine of man : outline notes based on Luthardt /

Contains a translation of the portions of Luthardt's "Kompendium der Dogmatik" dealing with man, sin, and free-will.

The Free press.

Description based on: Vol. 3, no. 2 (Aug. 23, 1856); title from caption.

A treatise on the faith of the Freewill Baptists : with an appendix, containing a summary of their usages in church government /

On spine: Faith of the Freewill Baptists.

Descriptive sketches of Tunbridge Wells and the Calverley estate : with brief notices of the picturesque scenery, seats, and antiquities in the vicinity /

The plates are lithographs.

Hymns for Christian melody. Selected from various authors...

Without music.

Mazzini, and other essays,

The essay entitled "Emerson's wit and humor" was first published in the Forum.

A select collection of old plays : in eight volumes ; with additional notes and corrections /

Apparently an edition made up from the 12 v. ed. of 1825-27, omitting v. 2-4 and 10.