905 resultados para Excipients for tablets
Resumo:
Cassava contributes significantly to biobased material development. Conventional approaches for its bio-derivative-production and application cause significant wastes, tailored material development challenges, with negative environmental impact and application limitations. Transforming cassava into sustainable value-added resources requires redesigning new approaches. Harnessing unexplored material source, and downstream process innovations can mitigate challenges. The ultimate goal proposed an integrated sustainable process system for cassava biomaterial development and potential application. An improved simultaneous release recovery cyanogenesis (SRRC) methodology, incorporating intact bitter cassava, was developed and standardized. Films were formulated, characterised, their mass transport behaviour, simulating real-distribution-chain conditions quantified, and optimised for desirable properties. Integrated process design system, for sustainable waste-elimination and biomaterial development, was developed. Films and bioderivatives for desired MAP, fast-delivery nutraceutical excipients and antifungal active coating applications were demonstrated. SRRC-processed intact bitter cassava produced significantly higher yield safe bio-derivatives than peeled, guaranteeing 16% waste-elimination. Process standardization transformed entire root into higher yield and clarified colour bio-derivatives and efficient material balance at optimal global desirability. Solvent mass through temperature-humidity-stressed films induced structural changes, and influenced water vapour and oxygen permeability. Sevenunit integrated-process design led to cost-effectiveness, energy-efficient and green cassava processing and biomaterials with zero-environment footprints. Desirable optimised bio-derivatives and films demonstrated application in desirable in-package O2/CO2, mouldgrowth inhibition, faster tablet excipient nutraceutical dissolutions and releases, and thymolencapsulated smooth antifungal coatings. Novel material resources, non-root peeling, zero-waste-elimination, and desirable standardised methodology present promising process integration tools for sustainable cassava biobased system development. Emerging design outcomes have potential applications to mitigate cyanide challenges and provide bio-derivative development pathways. Process system leads to zero-waste, with potential to reshape current style one-way processes into circular designs modelled on nature's effective approaches. Indigenous cassava components as natural material reinforcements, and SRRC processing approach has initiated a process with potential wider deployment in broad product research development. This research contributes to scientific knowledge in material science and engineering process design.
Resumo:
Fysisk inaktivitet och stillasittande är stora hälsorisker då samhället idag blir allt mer beroende av teknologin både under fritid, inom arbetslivet och i skolan. Vårt syfte med denna studie är att undersöka om teknologin på något sätt påverkar barnens fysiska aktivitet negativt. Detta är en kvalitativ fallstudie med intervjuer och observationer som genomförts i två lågstadieklasser på två olika skolor med olika regler gällande användandet av teknologi. Ena skolan använder sig av surfplattor från och med förskoleklass medan den andra skolan inte börjar med teknologi, i form av datorer, förrän i sjundeklass. Undersökningens resultat visar att barnens fysiska aktivitet i skolmiljö inte påverkas nämnvärt av att skolorna har regler angående användandet av tekniska resurser. Utifrån våra observationer kan vi också se att det behövs mer fokus och riktlinjer på hur man kan förminska förslitningsskador från barnens dåliga hållning vid användandet av surfplatta i framtiden. Intervjuerna visar också att lärare tycker att mer ansvar bör läggas på föräldrarna än på skolorna för att få barnen mer aktiva och intresserade av en fortsatt aktiv livsstil.
Resumo:
Fully articulated hand tracking promises to enable fundamentally new interactions with virtual and augmented worlds, but the limited accuracy and efficiency of current systems has prevented widespread adoption. Today's dominant paradigm uses machine learning for initialization and recovery followed by iterative model-fitting optimization to achieve a detailed pose fit. We follow this paradigm, but make several changes to the model-fitting, namely using: (1) a more discriminative objective function; (2) a smooth-surface model that provides gradients for non-linear optimization; and (3) joint optimization over both the model pose and the correspondences between observed data points and the model surface. While each of these changes may actually increase the cost per fitting iteration, we find a compensating decrease in the number of iterations. Further, the wide basin of convergence means that fewer starting points are needed for successful model fitting. Our system runs in real-time on CPU only, which frees up the commonly over-burdened GPU for experience designers. The hand tracker is efficient enough to run on low-power devices such as tablets. We can track up to several meters from the camera to provide a large working volume for interaction, even using the noisy data from current-generation depth cameras. Quantitative assessments on standard datasets show that the new approach exceeds the state of the art in accuracy. Qualitative results take the form of live recordings of a range of interactive experiences enabled by this new approach.
Resumo:
RESUMO - Com a popularização de tablets e smartphones e as peculiaridades do desenvolvimento de aplicativos para esses dispositivos, surge a necessidade de adaptar os métodos de avaliação de usabilidade para resultados mais precisos. Este trabalho propõe o método Coldemob para validação de interfaces de aplicativos móveis com a participação de representantes do usuário final, com uma etapa presencial e uma etapa remota após o lançamento do aplicativo, detalhando a aplicação da segunda etapa. O método foi testado com um aplicativo do domínio agrícola e os resultados mostraram que ao incluir o usuário no processo de construção do aplicativo, a compreensão dos desenvolvedores acerca do domínio aumentou. A etapa remota se mostrou complementar à presencial, possibilitando um maior número de problemas identificados.
Resumo:
The idea of Grid Computing originated in the nineties and found its concrete applications in contexts like the SETI@home project where a lot of computers (offered by volunteers) cooperated, performing distributed computations, inside the Grid environment analyzing radio signals trying to find extraterrestrial life. The Grid was composed of traditional personal computers but, with the emergence of the first mobile devices like Personal Digital Assistants (PDAs), researchers started theorizing the inclusion of mobile devices into Grid Computing; although impressive theoretical work was done, the idea was discarded due to the limitations (mainly technological) of mobile devices available at the time. Decades have passed, and now mobile devices are extremely more performant and numerous than before, leaving a great amount of resources available on mobile devices, such as smartphones and tablets, untapped. Here we propose a solution for performing distributed computations over a Grid Computing environment that utilizes both desktop and mobile devices, exploiting the resources from day-to-day mobile users that alternatively would end up unused. The work starts with an introduction on what Grid Computing is, the evolution of mobile devices, the idea of integrating such devices into the Grid and how to convince device owners to participate in the Grid. Then, the tone becomes more technical, starting with an explanation on how Grid Computing actually works, followed by the technical challenges of integrating mobile devices into the Grid. Next, the model, which constitutes the solution offered by this study, is explained, followed by a chapter regarding the realization of a prototype that proves the feasibility of distributed computations over a Grid composed by both mobile and desktop devices. To conclude future developments and ideas to improve this project are presented.