Condutas terapêuticas para tratamento da Síndrome da Apnéia e Hipopnéia Obstrutiva do Sono (SAHOS) e da Síndrome da Resistência das Vias Aéreas Superiores (SRVAS) com enfoque no Aparelho Anti-Ronco (AAR-ITO)

Os autores apresentam uma revisão da literatura referente às alternativas de tratamento cirúrgicas e não-cirúrgicas para a Síndrome da Apnéia e Hipopnéia Obstrutiva do Sono (SAHOS) e para a Síndrome da Resistência das Vias Aéreas superiores (SRVAS) com enfoque no princípio de ação e evolução dos aparelhos de avanço mandibular e, em particular, no mecanismo dinâmico de ação do Aparelho Anti-Ronco® (AAR-ITO).

Investimento e financiamento: um enfoque sobre empresas de capital aberto

O objetivo do artigo é analisar os determinantes do investimento para uma amostra com 334 empresas no Brasil para o período de 1998 a 2000. As empresas foram selecionadas segundo o critério de liquidez acionário através do índice de negociabilidade de 1998 da Bolsa de Valores de São Paulo, que aponta o grau de liquidez das ações. Com isso, procuramos contribuir para o entendimento do financiamento das empresas no Brasil em condições de instabilidade macroeconômica.

A comunicação midiática da tecnociência: uma leitura a partir do enfoque cts

This paper has two basic aims. The first one is to propose a discussion about the journalistic potential of information regarding patents, trying to identify using some experiences, the characteristics of this techno-scientific product that, somehow, draws the attention of the media. The second one is to understand the relationship between media and patents from the perspective of the studies on Science, Technology and Society (STS). The following assumption is made: the media treatment of patents is still strongly marked by economic bias and follows the logic of the supply-linear model, under which, among other important ideas, basic research is followed by applied research and, then, by technological developments that allow the launch of a new product bringing benefits for society. The paper presents results from case studies of science communication involving patents of the Federal University of Silo Carlos (UFSCar), Brazil, indicating that they are an important source of news for the media, and emphasizing the importance of the media in the national and international discussions about the protection of intellectual work.

Estudo comparativo das complicações terapêuticas no Lúpus Eritematoso Sistêmico e nas glomerulopatias idiopáticas.

PURPOSE: To evaluate the therapeutic complications due to the use of immunosupressors in patients with nephropathy. METHODS: 76 patients who had used steroids and cyclophosphamide were retrospectively studied. The cases were divided into three groups: G1= 15 patients with Systemic Lupus Erythematosus without renal lesion; G2= 33 patients with lupus nephritis and G3= 28 patients with nephrotic syndrome owing to idiopathic glomerulopathy. RESULTS: There were no differences related to time of follow up (G1= 42.4 +/- 51, G2= 52.3 +/- 51, G3= 41.8 +/- 47.8 months), total used dosage of steroids (G1= 20, G2= 28, G3= 16 grams) and time of drug use (G1= 20, G2= 26, G3= 14.5 months). About cyclophosphamide use, there was no difference in the percentage of patients who used it (13% in G1, 51% in G2, 28% in G3), but the patients from G1 received lower total dosage than those from G2 (p<0.05). Cushingoid appearance, epigastric distress, psychiatric disorders, diabetes mellitus and ocular alterations occurred in all the three groups, with no statistically significant differences. The infections complications, those considered more severe clinically, were more frequent in G2 (G1= 6%, G2= 15%, G3= 0% - p<0.05), the same occurring with the deaths (7% in G1, 30% in G2, 0% in G3 - p<0.05). CONCLUSION: In patients with lupus nephritis there were more infections complications owing to prolonged immunosuppresion what may indicate a severity marker of this type of lesion.

Sistemas para liberação colônica: Uma alternativa para a veiculação de fármacos para efeito local ou sistêmico

Problems related to the systemic administration of drugs, such as biodistribution, difficulty of targeting, necessity of high doses to achieve adequate levels of the drug in specific sites, toxicity, and undesirable side effects have lead to the development of systems able to direct the drug to specific sites in the body. Among the possible organs to the targeting of drugs, the colon can be used for local and systemic therapies. By developing such systems some models have been tested, using pH dependent release, release controlled by enzymatic degradation, time controlled release systems and pressure controlled release systems. This review presents an overview of the colonic release of drugs and the strategies used to achieve such targeting.

Bienestar y estar bien: un enfoque renovado de la cohesión social en América Latina

Incluye Bibliografía

A inflação chilena: um enfoque heterodoxo

Incluye Bibliografía

Desenvolvimento, subdesenvolvimento, dependência, marginalização e desigualdades espaciais: por um enfoque totalizante

Incluye Bibliografía

Formación de capital y entorno macroeconómico: bases para un enfoque estructuralista

Incluye Bibliografía

La eficacia de la política fiscal y los déficit privados: un enfoque macroeconómico

Incluye Bibliografía

Aglomeraciones pesqueras en América Latina: ventajas asociadas al enfoque de cluster

Incluye Bibliografía

Equidad y transformación productiva: un enfoque integrado

Incluye Bibliografía

La inflación chilena: un enfoque heterodoxo

Incluye Bibliografía

Desarrollo, subdesarrollo, dependencia, marginación y desigualdades espaciales: hacia un enfoque totalizante: selección

Incluye Bibliografía