Audit report on Pocahontas County, Iowa for the year ended June 30, 2009

Audit report on Pocahontas County, Iowa for the year ended June 30, 2009

Audit report on the Disaster Grants – Public Assistance program of the Green Bay Levee and Drainage District in Lee County, Iowa for the year ended June 30, 2009

Audit report on the Disaster Grants – Public Assistance program of the Green Bay Levee and Drainage District in Lee County, Iowa for the year ended June 30, 2009

Audit report on the Cedar County Economic Development Commission for the years ended June 30, 2009, 2008 and 2007

Audit report on the Cedar County Economic Development Commission for the years ended June 30, 2009, 2008 and 2007

Report on a special investigation of the Muscatine County Drug Task Force for the period January 1, 2004 through November 30, 2009

Report on a special investigation of the Muscatine County Drug Task Force for the period January 1, 2004 through November 30, 2009

Audit report on the Disaster Grants – Public Assistance program of the Iowa River - Flint Creek Levee District in Des Moines County and Louisa County, Iowa for the year ended June 30, 2009

Audit report on the Disaster Grants – Public Assistance program of the Iowa River - Flint Creek Levee District in Des Moines County and Louisa County, Iowa for the year ended June 30, 2009

Audit report on the Disaster Grants – Public Assistance program of Louisa – Des Moines County Drainage District in Des Moines County and Louisa County, Iowa for the year ended June 30, 2009

Audit report on the Disaster Grants – Public Assistance program of Louisa – Des Moines County Drainage District in Des Moines County and Louisa County, Iowa for the year ended June 30, 2009

Report on a special investigation of certain driver’s license collections at the Sioux County Treasurer’s Office for the period July 1, 2009 through May 31, 2010

Report on a special investigation of certain driver’s license collections at the Sioux County Treasurer’s Office for the period July 1, 2009 through May 31, 2010

Report on the Iowa Judicial Branch – County Clerks of District Courts, a part of the State of Iowa, for the year ended June 30, 2009

Report on the Iowa Judicial Branch – County Clerks of District Courts, a part of the State of Iowa, for the year ended June 30, 2009

Audit report on Washington County, Iowa for the year ended June 30, 2009

Audit report on Washington County, Iowa for the year ended June 30, 2009

Audit report on the South Dallas County Landfill Agency for the year ended June 30, 2010

Audit report on the South Dallas County Landfill Agency for the year ended June 30, 2010

Audit report on Adair County, Iowa for the year ended June 30, 2010

Audit report on Adair County, Iowa for the year ended June 30, 2010

Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells.

Interactions between Notch1 receptors on lymphoid progenitors and Delta-like 4 (DL4) ligands on cortical thymic epithelial cells (cTEC) are essential for T cell lineage commitment, expansion, and maturation in the thymus. Using a novel mAb against DL4, we show that DL4 levels on cTEC are very high in the fetal and neonatal thymus when thymocyte expansion is maximal but decrease dramatically in the adult when steady-state homeostasis is attained. Analysis of mutant mouse strains where thymocyte development is blocked at different stages indicates that lymphostromal interactions ("thymus crosstalk") are required for DL4 down-regulation on cTEC. Reconstitution of thymocyte development in these mutant mice further suggests that maturation of thymocytes to the CD4(+)CD8(+) stage and concomitant expansion are needed to promote DL4 down-regulation on cTEC. Collectively, our data support a model where thymic crosstalk quantitatively regulates the rate of Notch1-dependent thymopoiesis by controlling DL4 expression levels on cTEC.

Audit report on Muscatine County, Iowa for the year ended June 30, 2010

Audit report on Muscatine County, Iowa for the year ended June 30, 2010

Audit report on the Butler County Solid Waste Commission for the year ended June 30, 2010

Audit report on the Butler County Solid Waste Commission for the year ended June 30, 2010

Reaudit report on Cass County Memorial Hospital in Atlantic, Iowa for the period July 1, 2008 through June 30, 2009

Reaudit report on Cass County Memorial Hospital in Atlantic, Iowa for the period July 1, 2008 through June 30, 2009