Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study.

OBJECTIVES: The purpose of this study was to evaluate the association between inflammation and heart failure (HF) risk in older adults. BACKGROUND: Inflammation is associated with HF risk factors and also directly affects myocardial function. METHODS: The association of baseline serum concentrations of interleukin (IL)-6, tumor necrosis factor-alpha, and C-reactive protein (CRP) with incident HF was assessed with Cox models among 2,610 older persons without prevalent HF enrolled in the Health ABC (Health, Aging, and Body Composition) study (age 73.6 +/- 2.9 years; 48.3% men; 59.6% white). RESULTS: During follow-up (median 9.4 years), HF developed in 311 (11.9%) participants. In models controlling for clinical characteristics, ankle-arm index, and incident coronary heart disease, doubling of IL-6, tumor necrosis factor-alpha, and CRP concentrations was associated with 29% (95% confidence interval: 13% to 47%; p < 0.001), 46% (95% confidence interval: 17% to 84%; p = 0.001), and 9% (95% confidence interval: -1% to 24%; p = 0.087) increase in HF risk, respectively. In models including all 3 markers, IL-6, and tumor necrosis factor-alpha, but not CRP, remained significant. These associations were similar across sex and race and persisted in models accounting for death as a competing event. Post-HF ejection fraction was available in 239 (76.8%) cases; inflammatory markers had stronger association with HF with preserved ejection fraction. Repeat IL-6 and CRP determinations at 1-year follow-up did not provide incremental information. Addition of IL-6 to the clinical Health ABC HF model improved model discrimination (C index from 0.717 to 0.734; p = 0.001) and fit (decreased Bayes information criterion by 17.8; p < 0.001). CONCLUSIONS: Inflammatory markers are associated with HF risk among older adults and may improve HF risk stratification.

17/2/20, Mardi gras, sans-culottes à Montmartre [personnes déguisées] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58078

« Passetems chronologique et historique, ou Coup d'oeil recréatif sur le règne des khalifes, des roix et des sultans d'Égipte [632-1620], de la composition du cheikh, le plus docte des docteurs, MERYI fils de Jousuf, hanbelite et natif de Jérusalem ; traduit par le citoyen VENTURE [DE PARADIS], secrétaire-interprète de la République française pour les langues orientales. A Alger, 1789 ».

Contient : « Principes du gouvernement musulman, selon la doctrine de l'imam Hanbel »

初學玉玲瓏Chu xue yu ling long.Traité de composition.

Sur les divisions d'une pièce de wen zhang, avec exemples (thèmes des Quatre Livres). Par Xu Xuan Jing xian, de Tang ; préface de l'auteur (1750). Réédition de la salle Zhi yi (1835).4 livres.