983 resultados para Bohemia (Czech Republic)


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Recent publications allow us to conclude that the economic relations between Germany and Central Europe have come to the ‘end of history’, and nothing new will happen. However, a deeper analysis of these relationships reveals interesting new trends. Since joining the European Union the states of Central Europe have not settled for maintaining the average level of economic development, but have continued to narrow the distance between them and Western Europe, something which the global financial crisis did not prevent. Their improved economic situation also affected their relations with Germany. The latest results from the Visegrád Group states show them to be Germany’s most important trading partner, and their balance of trade in goods is in a state of equilibrium, while many euro area countries have recorded high trade deficits with Germany. The aim of this report is to display the trends in trade and investment between Germany and Central Europe, based on the example of the Visegrád Group. The author will also attempt to answer the question of whether the advancing economic cooperation between Germany and the V4 countries will lead to the further modernisation of those countries’ economies, or whether it will run the risk of leaving them in the ‘middle income trap’.

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In the last few years, several EU member states have reduced support to renewable energy, leading to numerous claims that these policy changes retroactively affected existing investments and that the practice of ‘grandfathering’ should have been observed. Among these, the case of Spain stands out, both due to the material size of the cuts and the large volume of investments affected, although the Czech Republic, Bulgaria, Poland, Romania and Italy have also introduced reforms with deleterious consequences to their renewable energy sectors.

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Rhomboid intramembrane proteases are the enzymes that release active epidermal growth factor receptor (EGFR) ligands in Drosophila and C. elegans, but little is known about their functions in mammals. Here we show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes trafficking of several membrane proteins, including the EGFR ligand TGFα, from the endoplasmic reticulum (ER) to the Golgi apparatus, thereby triggering their secretion by extracellular microvesicles. Our data also demonstrate that RHBDL4-dependent trafficking control is regulated by G-protein coupled receptors, suggesting a role for this rhomboid protease in pathological conditions, including EGFR signaling. We propose that RHBDL4 reorganizes trafficking events within the early secretory pathway in response to GPCR signaling. Our work identifies RHBDL4 as a rheostat that tunes secretion dynamics and abundance of specific membrane protein cargoes.

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Suspended publication during Oct. 1942-June 1945, when Česky časopis filologicky was published instead.

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Signatures: )(⁶ (+1) A-R⁴ S².

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Pieter Bruegel the Elder; oil on wood

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"August 1912, 43. Bereinsjahr."

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Description based on: 43. Jahrg., 1. Heft, published in 1904; title from caption.

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Vols. for 1926-1934 (Jahrg. 64-72) include Beilage für Archiv- und Musealwesen und für Denkmalpflege; vols. for 1864-1914 (Jahrg. 2-53) include Literarische Beilage.

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Vols. 37- (1931- ) in 2 separately paged sections: Skupina pravěká, Skupina historická.

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Has supplements.

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Himmelfahrt zu "Gott Vaterlos" -- Des Kreuzwegs letzter Stern -- Die Wunde des Ludwig Perls -- Hilflose Augen.

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Mode of access: Internet.