Morfoanatomia e histoquímica de órgãos vegetativos e reprodutivos de Brosimum gaudichaudii Trecul (Moraceae)

Pós-graduação em Ciências Biológicas (Botânica) - IBB

Doença periodontal em puérperas com parto prematuro

Pós-graduação em Ginecologia, Obstetrícia e Mastologia - FMB

Avaliação da atividade antinociceptiva e anti-inflamatória de Mikania lindleyana DC: validação do uso na medicina popular

Mikania lindleyana (Asteraceae), popularmente conhecida como sucuriju, é uma espécie nativa da região amazônica, cujo chá das folhas é a principal forma de uso popular para tratamento de gastrite, infecção, dor e inflamação. Para validar a forma e a alegação de uso decidiu-se avaliar a toxicidade aguda e as atividades antinociceptiva e anti-inflamatória do extrato bruto aquoso liofilizado de Mikania lindleyana devidamente identificada (EAML), bem como investigar sua composição química. Na análise fitoquímica do EAML detectou-se a presença de saponinas, proteínas, aminoácidos, fenóis, taninos, ácidos orgânicos e flavonoides. Por cromatografia em camada delgada (CCD) foram observadas zonas de fluorescência azul características de ácido o-cumárico. Por cromatografia liquida acoplada à espectrometria de massa (CLAE-DAD-EM) foram encontrados compostos altamente glicosilados. O EAML na dose de 5000mg/kg não provocou morte nos animais. No teste de contorções abdominais, o EAML (nas doses 125, 250, 500, 750, 1000 e 1500mg/kg) promoveu redução no número de contorções de maneira significante e dose-dependente. A dose efetiva mediana (DE₅₀) de 692,6 mg/kg não prolongou o tempo de latência sobre a placa quente. No teste de formalina, o EAML reduziu o tempo no qual os animais permaneceram lambendo a pata injetada com formalina nas duas fases sendo este efeito revertido pelo antagonista opioide naloxona. A dose de 692,6 mg/kg inibiu a formação de eritema, mas não o edema provocado por dextrana. A mesma dose inibiu a formação do edema por carragenina a partir da 2ª hora e reduziu a migração de neutrófilos para a cavidade peritonial. Estes resultados sugerem que o EAML, nas doses utilizadas, apresenta atividade antinociceptiva na qual pode haver a participação do sistema opioide e, apresenta atividade anti-inflamatória que pode ser atribuída à ação sobre mediadores inflamatórios, como PGs, e, ainda sobre moléculas de adesão, cuja participação de citocinas pode ser crucial.

Effect of copaiba oil in hepatic damage induced by acetaminophen in rats

PURPOSE: To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol. METHODS: Thirty six rats were distributed into six study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours afther the acetaminophen; and N-Acetyl-Cysteine Group, , that received the N-Acetyl-Cysteine two hours afther the acetaminophen. Euthanasia was performed after 24 hours. The serum levels of AST, ALT, alkaline phosphatase, GT, total bilirubin, direct bilirubin and indirect bilirubin and histological analisis were analized. RESULTS: The prophylactic copaiba group 7, therapy copaiba group and N-Acetyl-Cysteine Group showed amounts of AST and ALT similar to the control group; and the prophylactic copaiba group 1 showed similar levels to the acetaminophen group. There was no significant difference between the groups regarding the amount of alkaline phosphatase and GT (p>0.05). The therapy copaiba group showed the highest levels of bilirubin and was statistically different from the other groups (p<0.01) and this increased the costs of direct bilirubin. Regarding histopathology, the oil of copaiba administered prophylactic or therapeutic form for 7 days could decrease the amount of necrosis and inflammatory infiltrate. CONCLUSION: Copaiba oil administered prophylactically for seven days, and therapeutic could reduce liver damage caused by paracetamol similarly N-Acetyl-Cysteine, however, when treated with copaiba therapeutically showed increases in bilirubin, costs increasing fraction indirect.

Implementação da educação inclusiva: análise do projeto político pedagógico das escolas

The Policy Pedagogical Project can be understand like a guide element of education actions, that links itself to a history social project, bringing an specific way to understand the school and its function in society. The actual brazilian legislation is based on inclusive educational policy defended since 1990 by Ministry of Education. Faced this situation the present research intends verify if the schools are organized to act into this new paradigm, using analisis of the Policy Pedagogical Projects. That's why were analized the projects of 6 public schools of basic study that attend impaired students in regular classes. Those projects were analized based on a inclusive school indicators purposed by the Ministry of Education, that is based on a specific theorical reference and on determined actions that favor the impaired student learning. The data pointed that the majority of schools shows in theorical camp assumptions vinculated to Inclusive Education Policy. However, the presented actions are still shy and limited, so there is no differentiated purpose that attend the educational needs of impaired students. It concludes that the speech about inclusive education have already been assimilated by the school, however the actions are still begginers. The Pedagogical Project colectively built, could constitute an effective instrument to think about an make a quality school, an emancipatory school for all.

A religião, a magia e o canto de Orfeu na Argonáutica de Apolônio de Rodes

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

A leitura promovendo o uso adequado da variação linguística e do letramento

This Work focuses the importance of children‟s literature with the insertion of authors‟ like Aesopo, La Fontaine and Monteiro Lobato in the early years of elementary school, so that children could develop their reading that could bring reflections about the use of the language. It entends to show that books can give kids maturity to notice that when it comes to language there‟s not righ or wrong, but contexts that they should fit, in so that they can communicate and decrease the language prejudice. The authors studied in this study are the ones who study the language, the importance of children‟s literature and language prejudice at schools. This work was done through quantitative and qualitative approach, divided into 2 parts, observation and interventions, the research could be in touch with the observed class and get information about the students. Later the researcher could act by telling stories and get data. A third-grade class in a public school in the year of 2010, was observed during the internship in the early years of elementary school compared to another fourth grade class of another public school. The results and analisis oh the data show kids‟ lack of contact with an appropriate children‟s literature, like the fables which are short tales with moral and romance like Emília no País da Gramática by Monteiro Lobato, would make it difficult to learn the production of consistent texts and appropriate language in different contexts. Schools play an important role for kids to be in touch with these good books, so they should have the main role in the children‟s development and background, making them able to be aware of the importance of reading and writing in their lives. Most of the children found it difficult to write texts, but in the end they reached a god level of language related to the proposed context, writing consistent texts, but the part of children still mistake and in literacy and language adaptation

O ato alimentar em três espécies de Artibeus de grande porte (Chiroptera: Phyllostomidae) do Sudeste brasileiro

The alimentary act of three species of frugivorous bats of the genus Artibeus: A. lituratus, A. fimbriatus and A. planirostris, in a total of nine individuals, was studied by observations in field and captivity, during the months of May to September of 2008. With the objective to caracterize the form of consumption of two tipes of fruits (soft and consistent) and it relates with the dentary structure of this bats, the alimentary act was film and analysed later. It had little variation between the species. The fruits had been consumed in similar way, being that statistics analisis had demonstrated that consistent fruits had received more lateral bytes than the soft fruits. The dentary analisis shown that the posterior teeth (pre-molar and molar) present important characteristcs to triturate pieces of more consistent fruits and the incisors serve to scrape the pulp of the soft fruits. This study it served to describe the form of feeding of frugivorous bats, that little is explained in the studies of alimentary behavior

Análise comparativa de características seminais de Mazama cinzas brasileiros: morfometria espermática e proteômica do plasma seminal

Pós-graduação em Medicina Veterinária - FCAV

Tom e Vinícius na Alvorada: um prisma geográfico

This article has been generated by the interface between geography and music. Methodologically, we have used a multidisciplinary bibliography that contemplates cultural geography, history, music, linguistics, literature, anthropology, for we understand that, for the understanding of a polysemous code, as it is in music, we need a diversity of looks. Our main document for an analysis of the construction of Brasília is the “Sinfonia da Alvorada” (Symphony of the Dawn), composed by Antônio Carlos Jobim and Vinícius de Moraes. Here, we attempt mainly to do a textual analysis of the work under an external perspective of the symphonic work, we mean, analyzing more its semantics (considering the product between interlocution and interpretation), and less its instrumental aesthetics, although the latter is also present. Finally, we attempt to understand the connection that exists between the actors and the spaces which are metamorphosing along with the construction of the city and which puts into evidence the idea of social circularity, proposed by the “Sinfonia da Alvorada”. This piece captures social and cultural elements related to the construction of Brasília and repositions and rearranges it through the execution of the music, in such a way that this arrangement can provide a change in the senses which are constructed from the urban experience in Brasília.

Biofilmes multiespécies de Candida Albicans associados com streptococcus mitis e streptococcus sanguinis: estudo in vitro e in vivo

Pós-graduação em Odontologia Restauradora - ICT

Estudo sobre as respostas diferenciadas de 3 espécies de roedores à fragmentação da Mata Atlântica, utilizando uma abordagem integrativa do balanço hídrico

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Clusters of leprosy transmission and of late diagnosis in a highly endemic area in Brazil: focus on different spatial analysis approaches

Objective The Brazilian National Hansens Disease Control Program recently identified clusters with high disease transmission. Herein, we present different spatial analytical approaches to define highly vulnerable areas in one of these clusters. Method The study area included 373 municipalities in the four Brazilian states Maranha o, Para ', Tocantins and Piaui '. Spatial analysis was based on municipalities as the observation unit, considering the following disease indicators: (i) rate of new cases / 100 000 population, (ii) rate of cases < 15 years / 100 000 population, (iii) new cases with grade-2 disability / 100 000 population and (iv) proportion of new cases with grade-2 disabilities. We performed descriptive spatial analysis, local empirical Bayesian analysis and spatial scan statistic. Results A total of 254 (68.0%) municipalities were classified as hyperendemic (mean annual detection rates > 40 cases / 100 000 inhabitants). There was a concentration of municipalities with higher detection rates in Para ' and in the center of Maranha o. Spatial scan statistic identified 23 likely clusters of new leprosy case detection rates, most of them localized in these two states. These clusters included only 32% of the total population, but 55.4% of new leprosy cases. We also identified 16 significant clusters for the detection rate < 15 years and 11 likely clusters of new cases with grade-2. Several clusters of new cases with grade-2 / population overlap with those of new cases detection and detection of children < 15 years of age. The proportion of new cases with grade-2 did not reveal any significant clusters. Conclusions Several municipality clusters for high leprosy transmission and late diagnosis were identified in an endemic area using different statistical approaches. Spatial scan statistic is adequate to validate and confirm high-risk leprosy areas for transmission and late diagnosis, identified using descriptive spatial analysis and using local empirical Bayesian method. National and State leprosy control programs urgently need to intensify control actions in these highly vulnerable municipalities.

MAXIMAL PSEUDOCOMPACT AND MAXIMAL R-CLOSED SPACES

In this paper a space X is pseudocompact if it is Tychonoff and every real-valued continuous function on X is bounded. We obtain conditions under which a Tychonoff space is maximal pseudocompact and study conditions under which a regular space is maximal R-closed.

Avaliação do processo de acolhimento em Saúde Mental na região centro-oeste do município de São Paulo: a relação entre CAPS e UBS em análise

Este trabalho relata a experiência de avaliação do acolhimento em saúde mental na cidade de São Paulo-SP, utilizando entrevistas com trabalhadores de um Centro de Atenção Psicossocial (CAPS) e duas Unidades Básicas de Saúde (UBS). Objetivou entender o acolhimento, considerando a percepção dos trabalhadores e identificando o vínculo e a articulação da rede nesse processo. Utilizou-se como método a hermenêutica filosófica, para identificar que elementos participantes do processo de acolhimento poderiam ser destacados. Procedeu-se à análise das narrativas a partir de três linhas de argumentação: vínculo, acolhimento e articulação da rede - resultando em quatro categorias: sensação de ausência; mistura de modelos; primazia em tecnologias duras; e ineficiência quanto à integralidade. A discussão apontou uma imbricação dessas categorias, colocando o investimento em tecnologias leves como centro do debate para a superação da sensação de ausência, da mistura dos modelos e para construção da integralidade do cuidado.