Effective Use of Alteplase for Occluded Tunneled Venous Catheter in Hemodialysis Patients

Despite their propensity for significant infectious and mechanical complications, tunneled central venous catheters (CVCs) have become a common means of vascular access in the world for patients requiring chronic hemodialysis for end-stage renal disease. The objective of this study was to explore if cryopreserved solutions of the thrombolytic agent alteplase could be used as an effective, safe, and economically reasonable alternative in hemodialysis patients with occluded tunneled CVC. Patients requiring chronic hemodialysis and presenting with occluded tunneled CVC received a sufficient volume of the alteplase solution to fill the occluded catheter. To make alteplase economically feasible, it was diluted to 1-mg/mL aliquots and they were stored at -20 degrees C until use. Eighty-one patients accounting for 179 attempted clearances were assessable for efficacy. One hundred forty-seven (82.1%) of the 179 catheter clearance attempts resulted in successful catheter clearance after one dose. Twenty-seven (15.1%) of all occluded CVCs were successful after two doses whereas five (2.8%) were not. No adverse events were reported. Cryopreserved 1-mg/mL aliquots of alteplase are safe and effective in the clearance of occluded CVC for hemodialysis patients.

Why have land use change models for the Amazon failed to capture the amount of deforestation over the last decade?

Land cover change in the Neotropics represents one of the major drivers of global environmental change. Several models have been proposed to explore future trajectories of land use and cover change, particularly in the Amazon. Despite the remarkable development of these tools, model results are still surrounded by uncertainties. None of the model projections available in the literature plausibly captured the overall trajectory of land use and cover change that has been observed in the Amazon over the last decade. In this context, this study aims to review and analyze the general structure of the land use models that have most recently been used to explore land use change in the Amazon, seeking to investigate methodological factors that could explain the divergence between the observed and projected rates, paying special attention to the land demand calculations. Based on this review, the primary limitations inherent to this type of model and the extent to which these limitations can affect the consistency of the projections will also be analyzed. Finally, we discuss potential drivers that could have influenced the recent dynamic of the land use system in the Amazon and produced the unforeseen land cover change trajectory observed in this period. In a complementary way, the primary challenges of the new generation of land use models for the Amazon are synthesized. (c) 2014 Elsevier Ltd. All rights reserved.

Urethral striated muscle and extracellular matrix morphological characteristics among mildly diabetic pregnant rats: translational approach

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Bacterial leaf glands in Styrax camporum (Styracaceae): first report for the family

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Description of the larva of telebasis griffinii (Martin, 1896) (zygoptera: coenagrionidae)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Impactos da institucionalização na saúde mental do idoso

The present work proposes an analysis of the conditions of the elderly on a Brazilian context, focusing the institutionalized elders and the nuances of the institutionalization process on their mental health. Bibliographical analysis and participative observation were used as method. On the discussion, the present work demonstrates that the institutionalization have harmful effects to the elders, at their mental health and from this, proposes a multidisciplinary view of the process.

Lugar e Comunidades no Jardim Morada do Sol e Parque Residencial Francisco Belo Galindo: análise a partir de uma Estratégia de Educação de Jovens e Adultos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Cytochemical study of Rhodnius neglectus and Rhodnius prolixus salivary gland cells (Hemiptera, Triatominae)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Palavras em desdobramento na poesia de Herberto Helder

No poema Em silêncio descobri essa cidade no mapa, inserido em A máquina lírica (1964), Herberto Helder desenha um contra mapa desnorteante com as palavras, que pulalam na travessia da escrita, deslocando-se incessantemente e ocupando diferentes posições nos versos. A proliferação dos vocábulos que se cruzam em novas combinações dão origem aos fios cambiantes que se dobram, redobram e desdobram-se no tecido da linguagem que objetivamos desfiar neste trabalho.

Laboratório de Investigação de Paternidade FCFAr-UNESP: Histórico e Atualidades

The Laboratory of Investigation on Paternity - FCFAr-UNESP performs an outreach university activity according to 53, UNESP Resolution article 3 , published on November 3, 2004. This article is classified in Human Rights area involving community services, training highly qualified human resources and scientific development. This kind of service is performed with advanced technological resources and quality control similar to the international standard. in human identification by DNA research results are available . The laboratory offers a highly qualified service at a fair price, allowing the low-income population access to such tests.

A conversão de registros na implantação de repositórios institucionais: o caso do Repositório Institucional UNESP

O Repositório Institucional UNESP foi criado em 2013 e, para sua implantação, foi povoado com dados obtidos de forma automática. Considerando a experiência realizada na UNESP, este trabalho tem por objetivo apresentar os processos utilizados para a conversão dos registros coletados de três diferentes fontes de dados (Web of Science, SciELO e Scopus) para inclusão no repositório. A partir da coleta dos registros, os padrões de metadados da Web of Science, da SciELO e da Scopus foram mapeados para o perfil de aplicação de metadados utilizado no repositório. Os registros foram coletados como arquivos XML e, para sua conversão, foram elaboradas folhas de estilo utilizando a linguagem XSLT. Após essa conversão, os arquivos XML foram convertidos em arquivos CSV e, então, importados no Repositório. Conclui-se que os processos de conversão utilizados permitiram alcançar as metas iniciais do Repositório e evitaram a necessidade de inclusão dos registros de forma manual.

Seleção de espécies e procedências de Pinus sp para a região de Assis, Estado de São Paulo

Pós-graduação em Agronomia - FEIS