Derivados estruturais do peptídeo Histatina-5: síntese e aplicação no tratamento de candidose bucal

O uso contínuo de antifúngicos tópicos e sistêmicos no tratamento convencional de candidose oral tem resultado no aparecimento de Candida albicans resistente. Por este motivo, novas tecnologias para o desenvolvimento de drogas, como os biofármacos, constituem uma estratégia, além de inovadora devido a seu mecanismo de ação, também promissora no campo da biotecnologia. Verificou-se que esta nova tecnologia possui potencial efeito em diminuir a resistência de microrganismos, especialmente do agente etiológico da candidose bucal. A Candida albicans, agente patológico de origem fúngica, expressa diversos fatores de virulência sendo comumente encontrada na pele, cavidade oral, esôfago, trato gastrointestinal e órgão reprodutor feminino podendo acometer pessoas de idades variadas, imunologicamente comprometidas, ou que utilizam próteses dentárias. Nesse sentido, peptídeos com efeito antifúngico, produzidos por plantas, animais e microrganismos estão sendo utilizados como modelos para o desenvolvimento de novas drogas com aplicações em saúde. A Histatina 5 é um peptídeo encontrado na saliva humana com forte propriedade fungicida in vitro. Este peptídeo é extremamente rico nos aminoácidos histidina e lisina e, em pH fisiológico, possui potencial de inibição da formação do biofilme de Candida albicans, podendo ser aplicado portanto, no tratamento da candidose oral. Nesse contexto, o presente estudo consiste na obtenção de análogos da Histatina-5 com modificações em sua estrutura molecular, com o objetivo de otimizar o seu potencial terapêutico já verificado nos peptídeos da família das Histatinas. A Histatina 5SC possui o aminoácido serina C-terminal substituído pela cisteína, o qual é constituído pelo grupo sulfidrila em sua cadeia lateral, para a formação de dímeros. Os peptídeos foram desenvolvidos sinteticamente pelo método de Síntese Orgânica em Fase Sólida, utilizando-se a estratégia Fmoc e...

Síntese e estudos de sistemas de bioencapsulação associados a peptídeos antimicrobianos miméticos da toxina natural CcdB

Pós-graduação em Biotecnologia - IQ

Autonomia e reflexão nas práticas telecolaborativas em teletandem

New technologies have been playing an important role in providing access to foreign languages and cultures and to authentic communication. Telecollaborative practice can enrich foreign languages teaching and learning and the teachers’ formation processes. This paper focuses on the possibilities that emerge in teletandem for learners to practice autonomy and reflection. Teletandem is a distance tandem modality performed by audio and video conferences with tools such as Windows Live Messenger, Skype or ooVoo. This modality is presented by Teletandem Brasil Project: foreign languages for all. Based on a qualitative ethnographic study with Brazilian and foreign students, the results have shown that teletandem provides and encourages reflexive and autonomous attitudes.

O professor e a prática telecolaborativa no teletandem

The new technologies have increasingly provided access to foreign languages and cultures and also to authentic communication. If we consider that the foreign languages teaching/learning process and teachers’ education can be enriched by telecollaboration, I believe it is necessary to observe the roles played by language teachers. Based on an ethnographic qualitative study carried out with Brazilian and foreign university students, this paper focuses on teletandem practice, a distance tandem modality carried out by audio and video conferences with resources such as Windows Live Messenger, Skype or ooVoo, to investigate roles played by language teachers in telecollaborative practice. The data were collected from (a) e-mails exchanged between the partners and between partners and the mediator-teacher; (b) DVDs of interaction sessions recordings; (c) written teletandem sessions recordings; (d) recordings of interviews between the partners and the researcher at ooVoo; (e) fi eld notes taken at Teletandem Laboratory at UNESP- Assis; and (f) participants’ written reports. The data analysis, from the hermeneutic interpretative perspective, revealed that the teacher is not ignored but is given new roles to maximize the process towards meaningful and intercultural learning.

Vozes de professores: indícios de/para cursos de formação

In this article we analyze discourses of teachers on the linguistic practices of their students and discourses of future teachers. We consider studies of Bakhtin on dialogism and ideology in the production of meanings. Results indicate the following conclusions: the student in the analyzed discourses is a bad speaker, a bad writer, a bad reader, the great villain of language and reading in school is the advent of new technologies and languages which introduce new practices that have not been accepted by the interviewees. In this discourses, we can notice ways that can be taken into consideration in new teacher’s formation courses.

Innovation in pediatric surgery: the use of ultrasonic CVD tips: case report

The non-eruption of teeth due to highly keratinized gingival mucosa is a frequent event in the pediatric dentistry, which harms the oral aesthetics and function. A surgical excision of the involved area is indicated, exposing the non-erupted tooth. This procedure involves anesthesia and cutting instruments that may increase the fear and anxiety in young patients. The use of new technologies has avoided these instruments and has promoted more comfort to the patients. This study presents clinical cases in which gingivectomy was performed using the innovative method with an ultrasound-activated CVD tip. It was concluded that this method presented effectiveness, promoted more comfort, and less fear to the patients, making its use a viable alternative to pediatric surgery.

Redução do medo durante o tratamento odontológico utilizando pontas ultrassônicas

Over the last few years, new technologies have been developed to making cavity preparations, among which the diamond burs CVDentus® (CVDentus, São José dos Campos, Brazil) are outstanding. These points are produced by chemical deposition from the vapor phase, forming a single diamond stone, with greater durability than the conventional diamond burs. Coupled to the ultrasound appliance, they have several clinical applications in Dentistry with advantages over conventional rotary instruments, such as lower pressure, noise, vibration and heat, as well as reducing the need to use local anesthesia, contributing to minimize patient’s fear and anxiety. The aim of this study was to present the complete restorative dental treatment performed with this system in a child patient with a prior history of non-cooperative behavior. The use of this new technology offered the patient greater comfort, making it possible recondition the patient’s attitude to dental treatment, in addition to favoring conservative cavity preparations to be made.

Human identification by means of conventional and digital Cheiloscopy: a study of the literature

One of the areas of human identification is Cheiloscopy, the name given to the study of the lips, their characteristics (such as thickness, position of the grooves and grooves) and the record of the impressions left by them. There are variations in the layout of the lines and fissures of the lips, which are unique to each individual, permanent and unchanging. The lip print rarely changes, enduring minor traumas such as inflammation or sores. In criminal investigations, lip prints, visible through the presence of lipstick, can be found on glasses, napkins, clothes, cigarettes, indicating a relationship between the subject and the scene of the crime. Latent impressions may be revealed employing specific chemicals such as powder of silver and aluminum nitrate. Although it is not a very common method, Cheiloscopy may become very useful in forensics due to the extensive amount of valuable information that it brings. The objective of this study was to review the literature on the use of Cheiloscopy in human identification, using traditional and digital methods. It was found that the literature is still in need of studies in this area. The advent of new digital technologies can facilitate the implementation of technical expertise, generating speed and objectivity. New research studies are necessary, especially in the development of digital methods. The application of Cheiloscopy can greatlyhelp with Law, in the identification of living suspects and dead individuals. In the end the benefit will fall to society as a whole.

O ensino de informática para crianças: um estímulo à aprendizagem

The use of computers in childhood education makes it possible for them to acquire knowledge in a fun way through games. This paper describes the experience of implementing the course “Computers for Children”, which is part of a University Extension Program at the School of Dentistry at UNESP - Araraquara. This course is offered to children aged 5-7 years old and it aims, not only, to offer children, via computer, a direct contact with new teaching technologies, but also, to help them develop both their motor and logical thinking abilities through educational games. The children that participated in this course are from the Children’s Center “Casinha de Abelha” at the UNESP -Araraquara and also from the Municipal Recreation and Educational Centers also in Araraquara, SP, Brazil. The software resources used in this course to teach computer skills are the educational games “Coelho Sabido Maternal”, “A Estrela Cintilante” and “Festa dos Dentinhos”. The children’s learning and the level of difficulty in using the computer as a tool were evaluated. It was possible to conclude that the course has been contributing to the digital inclusion of children aged 5-7 years old, in addition to training their visual and audio perception, their motor coordination and memorization, hence developing skills that are essential to the children’s literacy process.

Transformações expansivas na produção matemática online

Pós-graduação em Educação Matemática - IGCE

Espaços projetados a partir da extensão: as experiências do núcleo de projetos arquitetônicos e urbanos

Pós-graduação em Planejamento, Urbanismo e Ambiente - FCT

A inovação para o desenvolvimento social: políticas públicas e internacionalização

Os sete textos aqui apresentados resultam de seleção realizada entre 296 trabalhos em outubro de 2013, durante o VII Congresso de Extensão Universitária da Unesp. Abrangem propostas inovadoras nas áreas de Direitos Humanos, Educação, Espaços Construídos, Política e Economia, Saúde e Tecnologia. O trabalho “Educação e Estatuto da Criança e do Adolescente (ECA)” propõe preparar agentes sociais e professores da cidade de Rio Claro e região para que o trabalho com as crianças e adolescentes possa ser mais efetivo em relação à aplicabilidade do ECA e para fortalecer as redes de atendimento. Em “Cursinho Pré-Vestibular Gera Bixo” o objetivo é a redução do déficit educacional do aluno proveniente do ensino público. O trabalho relata que em oito anos de existência o cursinho aprovou mais de duzentos alunos em universidades públicas ou particulares com 100% de bolsa e que o índice de aprovações alcançou 47% em 2012. “O direito à habitação e o papel da universidade pública” discute a habitação enquanto direito social assegurado pela Constituição. Trata de pesquisas e propostas alternativas para a habitação social que possibilitem custos mais baixos. Os autores de “Transparência e controle social: a experiência do Observatório da Gestão Pública de Marília (SP)” relatam como o Observatório viabiliza a prática do controle social da gestão e a advocacia de ideias no âmbito do município de Marília. O trabalho “Atendimento aos pacientes do Centro de Oncologia Bucal da Faculdade de Odontologia de Araçatuba Unesp” tem como objetivo ampliar o número e os tipos de atendimento de pacientes portadores de patologias bucais, orientar os alunos nos procedimentos de exame clínico, complementares e cirúrgicos, visando ao diagnóstico e tratamento das patologias bucais. Utilizar a jardinagem e a horticultura na recuperação de pacientes com dependência química, alcoólatras e desabilitados do Núcleo de Saúde Mental (Cerdif), de Ilha Solteira foi a proposta de “Jardinagem como terapia ocupacional na recuperação de pacientes do Cerdif/Ilha Solteira (SP). Em “Equipamentos para promoção de melhor qualidade de vida de pessoas com deficiência motora” os autores partiram do censo de 2010, segundo o qual 13,17 milhões de brasileiros declararam-se portadores de algum tipo de deficiência grave. Para contribuir com essa população, o Grupo de Pesquisa Novas Tecnologias e Qualidade de Vida dos Deficientes Físicos tem fabricado diversos equipamentos voltados à tecnologia assistiva.

Open design no cenário contemporâneo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Blog para o basquetebol: uma ferramenta no processo ensino-aprendizagem-treinamento dos sistemas táticos

Pós-graduação em Desenvolvimento Humano e Tecnologias - IBRC

Amizade e a virtualização das relações humanas na sociedade contemporânea: reflexões a partir de Zygmunt Bauman

This article analyzes the human bonds in the context of contemporary society from the work of the polish sociologist Zygmunt Bauman. Taking as starting point the bond of friendship and relational virtualization process motivated by the development of new technologies, it was observed the occurrence in the present world an affective-relational impoverishment. As an alternative to this, it is argued the exercise of building and maintenance of dense bonds that provide an alternative to the bind model of momentary satisfaction, this time marks. Finally, it is indicated that the discussion of friendship necessarily imply on the problematization of contemporary ethics which will provide the foundation for building a new affective political.