Kouvolan Sanomain Päätoimittaja 19/11 1974

Kirje 19.11.1974

Kirjekonsepti Elias Simojoelle 11.12.1938

Kirje

Informe sobre los viajes exploratorios entre Salaverry y Banco de Máncora, de los arrastreros Roncal y Tucán del 11 de setiembre al 1° de diciembre de 1968

Presenta información sobre los viajes realizados a bordo de los arrastreros Roncal y Tucán, para efectuar un reconocimiento parcial de la zona de pesca con miras a la identificación de las áreas apropiadas de las especies más importantes. Indica, que el recurso merluza es la especie más abundante por lo que se ubicó las áreas donde se concentra la merluza en tamaños comerciales.

In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1-.

Susceptibility of BALB/c mice to infection with Leishmania major is associated with a T helper type 2 (Th2) response. Since interleukin-4 (IL-4) is critically required early for Th2 cell development, the kinetics of IL-4 mRNA expression was compared in susceptible and resistant mice during the first days of infection. In contrast to resistant mice, susceptible mice exhibited a peak of IL-4 mRNA in their spleens 90 min after i.v. injection of parasites and in lymph nodes 16 h after s.c. injection. IL-12 and interferon-gamma (IFN-gamma) down-regulated this early peak of IL-4 mRNA; the effect of IL-12 was IFN-gamma dependent. Treatment of resistant C57BL/6 mice with anti-IFN-gamma allowed the expression of this early IL-4 response to L. major. The increased IL-4 mRNA expression occurred in V beta 8, 7, 2- CD4+ cells in BALB/c mice and NK1.1- CD4+ cells in anti-IFN-gamma treated C57BL/6 mice. These results show that the NK1.1+ CD4+ cells, responsible for the rapid burst of IL-4 production after i.v. injection of anti-CD3, do not contribute to the early IL-4 response to L. major.

Maisteri Antti Filppula 20/11 1972

Kirje 20.11.1972

President J. K. Paasikivi 27.11.1956 Härstädes

Kirje

Herr Chefredaktör Pentti Poukka 21.11.1971 Uusi Suomi

Kirje