999 resultados para episódios isquêmicos assintomáticos


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The oral records, deprived of great rhetoric elaboration, mark the family accounts and the testimonies about remarkable and apparently minor particularities of grand conflicts, like the World War II. The oral memory fulfilled an important function of historical transmission, especially in handing on to written record the organization of testimonies, revealing personal memories in the form of letters, diaries and narratives, besides of integrating itself to several works of fiction. In the present work we present the value of former partigiani’s testimonies collected in the volume Io sono l’ultimo (I am the last one) as evocation and transmission of personal remembrances strongly linked to the conflict and as manifestations in the literary field as well. The valuing by descendants and fellow countrymen of a tradition of memory communication make the testimony of men and women that fought for the liberation of many Italian locations much more than fragmented reports when the interested reader in the memory of those that survived, integrated to the micro-history of the events, perceive its expressive logic. We explore both the meaning of witness adopted by Giorgio Agamben and the esthetical value of the traumatized voice in the perspective of Márcio Seligman-Silva.

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While a certain novel ponders about the traces left by Ettore Majorana and expounds some theories about the fate of the character mysteriously disappeared, a movie by Gianni Amelio also inspirited by facts goes through another path, of the story of Via Panisperna boys, stressing the enigmatic figure of Ettore Majorana and the exciting episodes surrounding some of the greatest physicists of the world. When Leonardo Sciascia publishes the novel in which he uses the actual fact of Ettore Majorana’s disappearance in order to create what he calls a “philosophical novel of mystery”, the public had already probably forgotten the intriguing events of 1938: the young and bright physicist disappeared, by all accounts, voluntarily, without leaving proofs of his death or reliable evidence of his whereabouts. In 1972, Sciascia learns about mysterious clues by means of Erasmo Recami and considers the motives that could have made Majorana leave Italy and later abandon his life almost in the mode fictionalized by Pirandello.

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Purpose: Angiogenesis involves many mediators including integrins, and the tripeptide RGD is a target amino acid recognition sequence for many of them. Hindlimb ischemia is a simple and convenient animal model however standardization of the injection procedures in the devascularized and control limb is lacking, thus rendering difficult the interpretation of results. The aim of this investigations was to evaluate neovascularization in a hindlimb murine model by means of 99mTc-HYNIC-ß-Ala-RGD. Methods: 99mTc-HYNIC-RGD analog was prepared using coligands. Ischemia was induced in Wistar rats by double- ligation of the common femoral artery. Radiolabeled RGD was injected after 2h, as well as 1, 3, 5, 7, 10 and 14 days. Uptake was evaluated by planar imaging and biodistribution studies. Results: The highest ratio between ischemia and control was achieved at the 7th day (2.62 ± 0.95), with substantial decrease by the 14th day. For pertechnetate the 7th day ratio was 0.87 ± 0.23. Scintigraphic image confirmed different uptakes. Conclusion: 99mTc-HYNIC-RGD analog concentrated in ischemic tissue by the time of widespread angiogenesis and pertechnetate confirmed reduction in blood flow. In this sense, the protocol can be recommended for ischemic models.

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This review will focus on long-term outcomes after acute kidney injury (AKI). Surviving AKI patients have a higher late mortality compared with those admitted without AKI. Recent studies have claimed that long-term mortality in patients after AKI varied from 15% to 74% and older age, presence of previous co-morbidities, and the incomplete recovery of renal function have been identified as risk factors for reduced survival. AKI is also associated with progression to chronic kidney (CKD) disease and the decline of renal function at hospital discharge and the number and severity of AKI episodes have been associated with progression to CKD. IN the most studies, recovery of renal function is defined as non-dependence on renal replacement therapy which is probably too simplistic and it is expected in 60-70% of survivors by 90 days. Further studies are needed to explore the long-term prognosis of AKI patients.

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The aim of this work was to analyze the neuron morphology and morphometry of cervical, thoracic and lumbar areas of nonsymptomatic seropositive dogs’ spinal cord for toxoplasmosis. Twenty indefinite-breed adult dogs were used; ten dogs were healthy, with negative serology for toxoplasmosis, and were used as the control group (group 1), and ten dogs were nonsymptomatic but seropositive for toxoplasmosis (group 2). After the microtomy, with interval of 100 micrometers (µm), the histological 5-µm-thick cuts were dyed by hematoxylin-eosin and Masson's trichrome techniques. The glass slides were analyzed under light microscope to examine the neuron morphology. The parameters considered for the morphometric analysis were area, perimeter, maximum diameter, minimum diameter and shape factor of cytoplasm and nucleus of neuron. The results were statistically analyzed by Student’s t test at 5% probability level. The morphological characteristics between the two groups were similar and according to literature. The morphometric results showed that there were changes in neurons size and structure, and increase and loss of star shape were noticed in seropositive animals. The results suggest that the neurons of these dogs, yet nonsymptomatic, can have lost their conductor function.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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To establish guidelines based on cientific evidences for the management of cryopyrin associated periodic syndromes. The Guideline was prepared from 4 clinical questions that were structured through Pico (Patient, Intervention or indicator, Comparison and Outcome), to search in key primary scientific information databases. After defining the potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. 1215 articles were retrieved and evaluated by title and abstract; from these, 42 articles were selected to support the recommendations. 1. The diagnosis of Caps is based on clinical history and clinical manifestations, and later confirmed by genetic study. Caps may manifest itself in three phenotypes: FCAS (mild form), MWS (intermediate form) and Cinca (severe form). Neurological, ophthalmic, otorhinolaryngological and radiological assessments may be highly valuable in distinguishing between syndromes; 2. The genetic diagnosis with NLRP3 gene analysis must be conducted in suspected cases of Caps, i.e., individuals presenting before 20 years of age, recurrent episodes of inflammation expressed by a mild fever and urticaria; 3. Laboratory abnormalities include leukocytosis and elevated serum levels of inflammatory proteins; 4. Targeted therapies directed against interleukin-1 lead to rapid remission of symptoms in most patients. However, there are important limitations on the long-term safety. None of the three anti-IL-1β inhibitors prevents progression of bone lesions.

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Pós-graduação em Fisiopatologia em Clínica Médica - FMB

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Pós-graduação em Fisiopatologia em Clínica Médica - FMB

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This Project proposes a study of three documentaries about prostitution produced by a television program, Conexão Repórter (http://www.sbt.com.br/conexaoreporter/). These Journalistic Productions were chosen because they are episodes of a high-visibility program which purpose is to show the backstage of news. The study is based on social-anthropological productions about gender and sexuality, besides national and international literature about the subject. The analyses are completed with contributions from Journalism Theories, like Framing and Agenda-Setting. The studies developed by Michel Foucault on the historic aspect of sexuality will also be useful to support the ideas presented throughout the project. The goal is to analyze the construction of narratives about prostitution in all productions, taking as initial hypotheses that documentaries continue to reproduce stereotypes about the subject and, especially, what is the reason for such reproduction. The research seeks answers about journalist's challenges approaching prostitution. Starting from the hypothesis that the episodes in the study approach prostitution based on stereotypes, which other possible ways there may be to address the subject on TV documentaries? The goal is to relate the plots constructed by the reporting team with the theory in order to analyze discourses about the issue

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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The lateral movement presents a combination of lateral condylar and protrusive displacement on the non-working side. The objective os this study was to check the differences in the adjustment of the semiadjustable articulator starting from two different initial positions, centric relation an intercuspal position using positional records of rotusion and lateral movements in acrylic resin for the adjustment of condylar guidance as for ennett Angle. Twenty pacients dentate and assintomatic were recruited and their adjustment were performed in the semiadjustable articulator checking the differences among the studied groups, not finding statistically significant differences. Concludes that, in semiadjustable articulator adjustment, starting the montage in centric relation or intercuspal position, the results obtained for the condylar guidande and Bennett Angle aren´t statistically diferents, as well there is no difference in condylar guidance adjustment using lateral or protrusive records.