Mutually assured destruction or co-dependence? The G20 and the UN

The G20 forum has acted to crystallise important changes in the architecture of global governance emerging since the 1970s. This has seen the locus of power shift away from the United Nations (UN) System as smaller and poorer states become increasingly adept at exercising their power within UN structures. Yet it is too simple to set the G20 against the UN, for example as minilateralism versus multilateralism. While the UN seems increasingly constrained and less relevant, it is not about to disappear. Moreover, we argue there are two significant obstacles to the G20 claiming the mantle of dominant global governance institution. First, that minilateralism is still a form of multilateralism, and ultimately subject to the same problems with the generation of consensus if extended, as in the G20, to include sufficiently diverse state members for a claim of legitimacy. Second, its emergence from the Global Financial Crisis and historical focus on financial governance means its agenda is excessively narrow at a time when food and environmental crises command similar global political significance. We conclude by considering some of the different elements of the emerging G20/UN dynamic, and whether this emerging dialectic can enhance prospects for wide ranging reforms to global trade, finance and economic structures that are currently incapable of functioning sustainably or preventing wide scale famine.

MAKINGtheLINK : a school-based health promotion programme to increase help-seeking for cannabis and mental health issues among adolescents

Aim: There is increasing concern regarding the use of cannabis among adolescents, especially given recent evidence highlighting its link with later mental disorders. Encouraging young people with mental health or drug issues to seek professional help is an important early intervention strategy; however, adolescents are typically reluctant to do so and instead turn to their peers for help. Peers may not have the skills or knowledge required to assist their friends to access professional help. This paper describes the development and evaluation of MAKINGtheLINK, a school-based health promotion programme that promotes help-seeking behaviour for mental health and cannabis use issues among young people.

Methods: The MAKINGtheLINK programme was piloted with 182 Year 10 students at a secondary school in Melbourne, Australia. Forty teachers received the MAKINGtheLINK staff professional development session.

Results: The delivery of the MAKINGtheLINK programme was found to be both acceptable and feasible within a school setting. Students and teachers described it as a fun, engaging, helpful and important programme. Students reported increased confidence and awareness of how to seek help for themselves or a friend, and teachers indicated increased confidence and awareness of how to assist students to seek help for cannabis use and/or mental health problems.

Conclusions: MAKINGtheLINK was successfully implemented within the school curriculum. We believe this is the first school-based programme that specifically focuses on facilitating professional help-seeking for cannabis use and mental health problems among young people, and demonstrates that utilizing peer models for help-seeking is a valuable resource for early intervention initiatives.

Orientation dependence of the substructure characteristics in a Ni- 30%Fe austenitic alloy deformed in hot torsion

The present work examines the microstructure and texture evolution in a Ni-30wt.%Fe austenitic model alloy deformed in torsion at 1000 °C, with a particular emphasis on the orientation dependence of the substructure characteristics within the deformed original grains. Texture of these grains was principally consistent with that expected for simple shear and comprised the main A, B and C components. The deformation substructure within the main texture component grains was characterised by "organised" arrays of parallel microbands with systematically alternating misorientations, locally accompanied by micro-shear bands within the C grains. With increasing strain, the mean subgrain size gradually decreased and the mean misorientation angle concurrently increased towards the saturation. The stored deformation energy within the main texture component grains was principally consistent with the respective Taylor factor values. The microband boundaries corresponded to the expected single slip {111} plane for the A oriented grains while these boundaries for the C oriented grains represented a variety of planes even for a single grain.

The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence

Nicotine dependence is common in people with mood disorders; however the operative pathways are not well understood. This paper reviews the contribution of inflammation and oxidative stress pathways to the co-association of depressive disorder and nicotine dependence, including increased levels of pro-inflammatory cytokines, increased acute phase proteins, decreased levels of antioxidants and increased oxidative stress. These could be some of the potential pathophysiological mechanisms involved in neuroprogression. The shared inflammatory and oxidative stress pathways by which smoking may increase the risk for development of depressive disorders are in part mediated by increased levels of pro-inflammatory cytokines, diverse neurotransmitter systems, activation the hypothalamic-pituitary-adrenal (HPA) axis, microglial activation, increased production of oxidative stress and decreased levels of antioxidants. Depressive disorder and nicotine dependence are additionally linked imbalance between neuroprotective and neurodegenerative metabolites in the kynurenine pathway that contribute to neuroprogression. These pathways provide a mechanistic framework for understanding the interaction between nicotine dependence and depressive disorder.