The 10th Anniversary of the Junior Members and Affiliates of the European Academy of Allergy and Clinical Immunology

This year is the 10th anniversary of the European Academy of Allergy and Clinical Immunology (EAACI) Junior Members and Affiliates (JMAs). The aim of this review is to highlight the work and activities of EAACI JMAs. To this end, we have summarized all the initiatives taken by JMAs during the last 10 yr. EAACI JMAs are currently a group of over 2380 clinicians and scientists under the age of 35 yr, who support the continuous education of the Academy's younger members. For the past decade, JMAs enjoy a steadily increasing number of benefits such as free online access to the Academy's journals, the possibility to apply for Fellowships and the Mentorship Program, travel grants to attend scientific meetings, and many more. In addition, JMAs have been involved in task forces, cooperation schemes with other scientific bodies, organization of JMA focused sessions during EAACI meetings, and participation in the activities of EAACI communication platforms. EAACI JMA activities represent an ideal example of recruiting, training, and educating young scientists in order for them to thrive as future experts in their field. This model may serve as a prototype for other scientific communities, several of which have already adapted similar policies.

El patrocinio artístico femenino a través de la monarquía hispánicarchivo de ordenador] : Sancha de León, Isabel La Católica e Isabel de Farnesio

[ES]Análisis del patrocinio artístico ejercido por soberanas españolas de los siglos XI al XVIII. Las reinas elegidas son: Sancha de León (m. 1067) y su legitimación del poder a través de las artes y el tesoro de San Isidoro de León; Isabel de Castilla (1451-1504) y la pintura flamenca: su pintor de cámara Juan de Flandes; e Isabel de Farnesio (1692-1766) y la imposición del arte italiano en el siglo XVIII español con sus colecciones de escultura y pintura.

Adopción de tecnologías en banca electrónica

El estudio presenta el análisis de varios modelos teóricos con el fin de identificar las variables que explican el uso de banca electrónica por parte de los consumidores, basándose en la convergencia de tres enfoques: (i) modelos de medición de la calidad en servicios desde la perspectiva de los consumidores; (ii) modelos de aceptación de tecnologías basadas en teorías de las ciencias del comportamiento y (iii) modelos de calidad de plataformas tecnológicas desde un enfoque de calidad de las páginas web. Los resultados preliminares del estudio, aplicado en esta primera fase como prueba piloto, permiten identificar con altos índices de confiabilidad y validez los factores que explican el uso de la banca por Internet de las personas de nivel socioeconómico A/B en Lima.

Experimental viscosity measurements of biodiesels at high pressure

The viscosity of biodiesels of soybean and rapeseed biodiesels blended with mineral diesel fuel were measured at pressures of up to 200 MPa. Using a falling sinker-type viscometer reproducible viscosity data were obtained based on the time taken for a sinker to descend a fixed distance down an enclosed tube under the influence of gravity. Measurements were taken using pressures which correspond to those of interest in automotive common rail diesel engines, and at temperatures of between 25oC and 80oC. In all cases, the viscosity of the biodiesel blends were found to increase exponentially for which the blends were noted as being more viscous than pure mineral fuels. A pressure-freezing effect was not observed for the blends.

Parentalidade em tempos de mudança: articulando tempos de qualidade com tempo livre

Dissertação apresentada à Escola Superior de Educação de Paula Frassinetti para obtenção do grau de Mestre em Educação Pré-escolar

Cross-resistance to elvitegravir and dolutegravir in 502 patients failing on raltegravir: a French national study of raltegravir-experienced HIV-1-infected patients

International audience

Quantifying aggressive behavior in zebrafish

Aggression is a complex behavior that influences social relationships and can be seen as adaptive or maladaptive depending on the context and intensity of expression. A model organism suitable for genetic dissection of the underlying neural mechanisms of aggressive behavior is still needed. Zebrafish has already proven to be a powerful vertebrate model organism for the study of normal and pathological brain function. Despite the fact that zebrafish is a gregarious species that forms shoals, when allowed to interact in pairs, both males and females express aggressive behavior and establish dominance hierarchies. Here, we describe two protocols that can be used to quantify aggressive behavior in zebrafish, using two different paradigms: (1) staged fights between real opponents and (2) mirror-elicited fights. We also discuss the methodology for the behavior analysis, the expected results for both paradigms, and the advantages and disadvantages of each paradigm in face of the specific goals of the study.

Elaboració de la guia docent de l’assignatura Llengua Catalana aplicada a les Ciències de l’Activitat Física i l’Esport

El propòsit de la xarxa 3252 ha estat el de plantejar una sèrie de canvis en la guia docent de l’assignatura «Llengua Catalana aplicada a les Ciències de l’Activitat Física i l’Esport» (codi 16830), la qual, al nostre parer, acompleix els requisits de llengua d’ús homologable a d’altres d’impartides pel Departament de Filologia Catalana de la UA a la Facultat d’Educació, però no compta amb un inseriment adient en el marc dels estudis del grau que l’acull, ço és, CAFE. En aquest sentit, la memòria present vol ser testimoni dels canvis suggerits en pro d’un encaixament més orgànic i esclaridor d’acord amb una visió fonamentada en el Tractament Integrat de Llengua i Continguts.

Oratorio de religiosos y exercicio de virtuosos / compuesto por el Illustre señor don Antonio de Gueuara, ...

Capitulares grab. xil.

Tomus secundus Operum aliquot D. Gregorii Papæ huius nominis primi, cognomento magni, doctæ ac piæ institutionis refertissimorum : nunc denuo ad fidem veterum exemplarium accuratiori diligentia à mendis innumeris repurgatorum ...

Capitulares grab. xil.

VERIFYING SUCCESS OF ARTIFICIAL REEFS IN THE HURON-ERIE CORRIDOR FOR LAKE STURGEON

Lake sturgeon (Acipenser fulvescens) were historically abundant in the Huron-Erie Corridor (HEC), a 160 km river/channel network composed of the St. Clair River, Lake St. Clair, and the Detroit River that connects Lake Huron to Lake Erie. In the HEC, most natural lake sturgeon spawning substrates have been eliminated or degraded as a result of channelization and dredging. To address significant habitat loss in HEC, multi-agency restoration efforts are underway to restore spawning substrate by constructing artificial spawning reefs. The main objective of this study was to conduct post-construction monitoring of lake sturgeon egg deposition and larval emergence near two of these artificial reef projects; Fighting Island Reef in the Detroit River, and Middle Channel Spawning Reef in the lower St. Clair River. We also investigated seasonal and nightly timing of larval emergence, growth, and vertical distribution in the water column at these sites, and an additional site in the St. Clair River where lake sturgeon are known to spawn on a bed of ~100 year old coal clinkers. From 2010-12, we collected viable eggs and larvae at all three sites indicating that these artificial reefs are creating conditions suitable for egg deposition, fertilization, incubation, and larval emergence. The construction methods and materials, and physical site conditions present in HEC artificial reef projects can be used to inform future spawning habitat restoration or enhancement efforts. The results from this study have also identified the likelihood of additional uncharacterized natural spawning sites in the St. Clair River. In addition to the field study, we conducted a laboratory experiment involving actual substrate materials that have been used in artificial reef construction in this system. Although coal clinkers are chemically inert, some trace elements can be reincorporated with the clinker material during the combustion process. Since lake sturgeon eggs and larvae are developing in close proximity to this material, it is important to measure the concentration of potentially toxic trace elements. This study focused on arsenic, which occurs naturally in coal and can be toxic to fishes. Total arsenic concentration was measured in samples taken from four substrate treatments submerged in distilled water; limestone cobble, rinsed limestone cobble, coal clinker, and rinsed coal clinker. Samples were taken at three time intervals: 24 hours, 11 days, and 21 days. ICP-MS analysis showed that concentrations of total arsenic were below the EPA drinking water standard (10 ppb) for all samples. However, at the 24 hour sampling interval, a two way repeated measures ANOVA with a Holm-Sidak post hoc analysis (α= 0.05) showed that the mean arsenic concentration was significantly higher in the coal clinker substrate treatment then in the rinsed coal clinker treatment (p=0.006), the limestone cobble treatment (p

The Role of the Transcription Factor Ets1 in Melanocyte Development

Melanocytes, pigment-producing cells, derive from the neural crest (NC), a population of pluripotent cells that arise from the dorsal aspect of the neural tube during embryogenesis. Many genes required for melanocyte development were identified using mouse pigmentation mutants. The deletion of the transcription factor Ets1 in mice results in hypopigmentation; nevertheless, the function of Ets1 in melanocyte development is unknown. The goal of the present study was to establish the temporal requirement and role of Ets1 in murine melanocyte development. In the mouse, Ets1 is widely expressed in developing organs and tissues, including the NC. In the chick cranial NC, Ets1 is required for the expression of Sox10, a transcription factor critical for the development of melanocytes, enteric ganglia, and other NC derivatives. Using a combination of immunofluorescence and cell survival assays Ets1 was found to be required between embryonic days 10 and 11, when it regulates NC cell and melanocyte precursor (melanoblast) survival. Given the requirement of Ets1 for Sox10 expression in the chick cranial NC, a potential interaction between these genes was investigated. Using genetic crosses, a synergistic genetic interaction between Ets1 and Sox10 in melanocyte development was found. Since Sox10 is essential for enteric ganglia formation, the importance of Ets1 on gut innervation was also examined. In mice, Ets1 deletion led to decreased gut innervation, which was exacerbated by Sox10 heterozygosity. At the molecular level, Ets1 was found to activate a Sox10 enhancer critical for Sox10 expression in melanoblasts. Furthermore, mutating Ets1 at a site I characterized in the spontaneous variable spotting mouse pigmentation mutant, led to a 2-fold decrease in enhancer activation. Overexpression and knockdown of Ets1 did not affect Sox10 expression; nonetheless, Ets1 knockdown led to a 6-fold upregulation of the transcription factor Sox9, a gene required for melanocyte and chondrocyte development, but which impairs melanocyte development when its expression is prolonged. Together, these results suggest that Ets1 is required early during melanocyte development for NC cell and melanoblast survival, possibly acting upstream of Sox10. The transcription factor Ets1 may also act indirectly in melanocyte fate specification by repressing Sox9 expression, and consequently cartilage fate.

Asociación entre la escala de riesgo Framingham y el puntaje de calcio coronario

Introducción: Entre las diferentes herramientas clínicas para evaluar la presencia de enfermedad coronaria mediante puntajes, la más usada es la Escala de Riesgo cardiovascular de Framingham. Desde hace unos años, se creó el puntaje de calcio coronario el cual mide el riesgo cardiovascular según la presencia de placas ateromatosas vistas por tomografía computarizada. Se evaluó la asociación entre la escala de Framigham y el puntaje de calcio coronario en una población de sujetos sanos asintomáticos. Metodología: Se realizó un estudio transversal para evaluar la asociación entre el puntaje de calcio coronario y la escala de Framingham en sujetos asintomáticos que se practicaron exámen médico preventivo en la Fundación Cardioinfantil- Instituto de Cardiología (FCI-IC) en el periodo comprendido entre 1 de Julio 2011 hasta el 31 de octubre de 2015. Resultados: Se evaluaron 262 pacientes en total. La prevalencia de riesgo cardiovascular fue bajo en un 77.86% de la población, medio en 18.70% y alto en 3.44%, según la escala de Framingham. El riesgo cardiovascular según el puntaje de Calcio coronario fue nulo 70.99%, bajo en 21.75%, medio en 4.19%, severo en 3.05%. Se encontró una asociación entre ambos puntajes para riesgo estadísticamente significativa (p0,00001) Discusión: El riesgo cardiovascular establecido por escala de Framingham se relaciona de forma significativa con la presencia de placas aterioscleróticas. El estudio demostró que en una muestra de sujetos asintomáticos, hay una alteración estructural coronaria temprana.

Tendencia editorial UR Número 2

El Boletín Tendencia Editorial es un proyecto que nació en 2010 con motivo de la Feria Internacional del Libro de Bogotá para construir y hacer visibles diferentes saberes desde la academia y la edición. Para 2014, el cambio de periodicidad coincidió con uno de los eventos más importantes para la edición universitaria, la Feria Internacional del Libro de Guadalajara donde anualmente se realiza el encuentro de Editores Universitarios Latinoamericanos, el proyecto pasó de su fase nacional a ser pensado en red. Las líneas temáticas traspasan fronteras locales y convocan, en un mismo espacio, las voces de los gestores y especialistas, cuya labor y experiencia permiten cada día mejorar la edición universitaria, lo que posibilita acabar con el mito que concibe a la Universidad como ente ajeno a la sociedad, cuando en realidad esta es la forjadora de líderes, investigadores y emprendedores.

Serie de documentos Facultad de Jurisprudencia N° 75. Estado del arte del proyecto de invstigación. "Los daños antijurídicos producidos por los agentes de las Fuerzas Militares: límites al ejercicio de la fuerza del Estado como función pública"

La concepción de Estado moderno está íntimamente vinculada al ejercicio del monopolio legítimo de la fuerza, en tanto supone que la violencia es una de las principales prerrogativas que el Estado pretende detentar, para constituirse en una organización política de poder que perdure en la sociedad en la que se instaura. En este sentido, el proyecto de investigación tiene como uno de sus objetivos específicos, identificar, caracterizar y analizar los daños antijurídicos por los cuales el Comité de Conciliación del Ministerio de Defensa Nacional autoriza el ejercicio de la acción de repetición contra los funcionarios o ex-funcionarios de las Fuerzas Militares, limitando el análisis al periodo transcurrido durante los años 2010 a 2016. Lo anterior, con el fin de establecer cuáles son las causas generadoras de responsabilidad más frecuentes en las que han incurrido los agentes de la entidad, para luego observar su impacto en el erario de la nación y verificar cómo se constituyen en una necesidad de imposición de límites al ejercicio de la fuerza del Estado.