Semiparametric Estimation of Models for Natural Direct and Indirect Effects

In recent years, researchers in the health and social sciences have become increasingly interested in mediation analysis. Specifically, upon establishing a non-null total effect of an exposure, investigators routinely wish to make inferences about the direct (indirect) pathway of the effect of the exposure not through (through) a mediator variable that occurs subsequently to the exposure and prior to the outcome. Natural direct and indirect effects are of particular interest as they generally combine to produce the total effect of the exposure and therefore provide insight on the mechanism by which it operates to produce the outcome. A semiparametric theory has recently been proposed to make inferences about marginal mean natural direct and indirect effects in observational studies (Tchetgen Tchetgen and Shpitser, 2011), which delivers multiply robust locally efficient estimators of the marginal direct and indirect effects, and thus generalizes previous results for total effects to the mediation setting. In this paper we extend the new theory to handle a setting in which a parametric model for the natural direct (indirect) effect within levels of pre-exposure variables is specified and the model for the observed data likelihood is otherwise unrestricted. We show that estimation is generally not feasible in this model because of the curse of dimensionality associated with the required estimation of auxiliary conditional densities or expectations, given high-dimensional covariates. We thus consider multiply robust estimation and propose a more general model which assumes a subset but not all of several working models holds.

Leaving Home: Philo of Alexandria on the Exodus.

For Jewish-Hellenistic authors writing in Egypt, the Exodus story posed unique challenges. After all, to them Egypt was, as Philo of Alexandria states, their fatherland. How do these authors come to terms with the biblical story of liberation from Egyptian slavery and the longing for the promised land? In this chapter I am taking a close look at Philo’s detailed discussion of the Exodus and locate it within the larger context of Jewish-Hellenistic literature (Wisdom of Solomon, Ezekiel’s Exagoge). In Philo’s rewriting of the Exodus the destination of the journey is barely mentioned. Contrary to the biblical narrative, in the scene of the burning bush, as retold by Philo, God does not tell Moses where to go. Philo’s main concern is what happens in Egypt: both in biblical times and in his own days. The Exodus is nevertheless important to Philo: He reads the story allegorically as a journey from the land of the body to the realms of the mind. Such a symbolic reading permitted him to control the meaning of the Exodus and to stay, literally and figuratively, in Egypt.

Consideraciones en torno de la articulación entre investigación y docencia en educación superior : propuestas de estrategias de intervención e innovación

El presente artículo busca elaborar una reflexión a partir de un conjunto de experiencias en las que profesores del área de humanidades y ciencias sociales diseñaron y ejecutaron proyectos de intervención pedagógica, de carácter innovador, en el desarrollo de sus cursos, y luego los discutieron en el marco de los foros organizados por la red Innova/Cesal. Se abordan marcos de referencia que contribuyan al diseño de intervenciones pedagógicas y brinden insumos que orienten el trabajo de la docencia universitaria interesada en modificar su práctica educativa e innovar sus estrategias de enseñanza y aprendizaje.

Os (des)caminhos de um pesquisador do futebol brasileiro

The research in professional football within the human and social sciences, despite increased, still faced limitations and restrictions imposed by the clubs, hindering its realization. As part of my master's thesis, this article aims to portray the effects of leadership on the functioning of the group and to detect the importance and necessity of cohesion in a professional team of footballers. Furthermore, the relationship between the researcher and the football club was analyzed and described, as well as the limitations and obstacles encountered during field research. Following the guidelines of qualitative research and having social psychology as a theoretical background (Kurt Lewin and Pichon-Rivière), this research resulted from the analysis of a professional football club (players, staff and executives of a club with national and international importance) during 5 days of daily contact with the group in games, practice, concentration and meals. The difficulties in analyzing the group's leadership and cohesion were vast, among which stand out the difficulty or impossibility of access to the places-situations suggested as methodology, their refusals to interviews and rejection of the administration of a free choice test. The bond created and the roles taken harmed attempts for further analysis. Therefore, due to the characteristics of contemporary football, especially the financial and political interests the difficulties likely to arise range according to the characteristics of the institution

Os (des)caminhos de um pesquisador do futebol brasileiro

The research in professional football within the human and social sciences, despite increased, still faced limitations and restrictions imposed by the clubs, hindering its realization. As part of my master's thesis, this article aims to portray the effects of leadership on the functioning of the group and to detect the importance and necessity of cohesion in a professional team of footballers. Furthermore, the relationship between the researcher and the football club was analyzed and described, as well as the limitations and obstacles encountered during field research. Following the guidelines of qualitative research and having social psychology as a theoretical background (Kurt Lewin and Pichon-Rivière), this research resulted from the analysis of a professional football club (players, staff and executives of a club with national and international importance) during 5 days of daily contact with the group in games, practice, concentration and meals. The difficulties in analyzing the group's leadership and cohesion were vast, among which stand out the difficulty or impossibility of access to the places-situations suggested as methodology, their refusals to interviews and rejection of the administration of a free choice test. The bond created and the roles taken harmed attempts for further analysis. Therefore, due to the characteristics of contemporary football, especially the financial and political interests the difficulties likely to arise range according to the characteristics of the institution

Os (des)caminhos de um pesquisador do futebol brasileiro

The research in professional football within the human and social sciences, despite increased, still faced limitations and restrictions imposed by the clubs, hindering its realization. As part of my master's thesis, this article aims to portray the effects of leadership on the functioning of the group and to detect the importance and necessity of cohesion in a professional team of footballers. Furthermore, the relationship between the researcher and the football club was analyzed and described, as well as the limitations and obstacles encountered during field research. Following the guidelines of qualitative research and having social psychology as a theoretical background (Kurt Lewin and Pichon-Rivière), this research resulted from the analysis of a professional football club (players, staff and executives of a club with national and international importance) during 5 days of daily contact with the group in games, practice, concentration and meals. The difficulties in analyzing the group's leadership and cohesion were vast, among which stand out the difficulty or impossibility of access to the places-situations suggested as methodology, their refusals to interviews and rejection of the administration of a free choice test. The bond created and the roles taken harmed attempts for further analysis. Therefore, due to the characteristics of contemporary football, especially the financial and political interests the difficulties likely to arise range according to the characteristics of the institution

The pulpit and American life,

Contents.--The Puritan preacher.--Jonathan Edwards.--Lyman Beecher.--William Ellery Channing.--Horace Bushnell.--Henry Ward Beecher.--Phillips Brooks, the man and the preacher.--The old and new evangelism.--Some distinctive contributions to the American pulpit.--The present American pulpit.--The pulpit and social welfare.--The pulpit and the nation.

The health and nutritional status of multiethnic perimenopausal women

An integrated, dual-phase study design assessed the health and nutritional status and practices of African-American (A-A), Caribbean (A-C), and white non-Hispanic (W-A) women during perimenopause (40–55 years). During Phase I, four focus groups (n = 37) of male and female participants discussed the health and social implications of perimenopause. A conceptual framework for the main study (Phase II) was developed from the focus groups' findings, in concert with the main study's specific aims and objectives. ^ The main study, a cross-sectional survey, quantitatively assessed the health and nutritional status of a convenience sample of 109 women (25 A-A, 31 A-C and 53 W-A), who met specific eligibility criteria. Using seven instruments, sociodemographic, dietary, medical, reproductive health, health practice and anthropometric data were collected. ^ The groups were of comparable age, education, and socioeconomic status (SES). Despite these similarities, statistically significant interethnic nutritional status differences were found. Significantly more total energy and energy from fat were consumed by A-A than W-A and A-C women. Also, significantly more A-A and A-C than W-A women were overweight or obese with android-type weight patterning. ^ Overall, iron and calcium Recommended Dietary Allowances (RDA's) were not met by 35% and 68% of participants, respectively. Iron deficiency anemia was reported by 29% of participants while 33% reported heavier menstrual bleeding. Coupled with suboptimal iron intakes, this is likely to present a serious public health problem. Similarly, increased bone demineralization characteristic of perimenopause, coupled with suboptimal calcium intakes could precipitate another public health problem, osteoporosis. ^ Participants had different expectations about the role of medical care during perimenopause. Significantly more white (57%) than black (38% [A-A and AC]) women sought medical attention for symptoms. Whereas Hormone Replacement Therapy (HRT) was prescribed for 25% of them, only 13% were compliant at enrollment. ^ The trends and statistically significant findings of this study have huge public health policy implications. It is imperative that appropriate policies are formulated to ensure that America's ethnically diverse perimenopausal women have ready access to culturally appropriate care. This would optimize their health outcomes, and enhance their quality of life and productive capacities at this critical juncture of their lives. ^

Indicador de vulnerabilidade agropecuária a extremos climáticos para o nordeste do Brasil

The effects of climate change on human societies have become the focus of many researchers for their research. Understanding weather patterns (circulation of the atmosphere, precipitation, temperature) is essences for predicting extreme weather, but analyze how these extreme events act in our society and look for ways to reduce the impact caused by these events is the great challenge. Using a concept very in the humanities and social sciences to understand these impacts and the adaptation of the society's vulnerability. The objective of this work is to develop and apply a methodology for evaluating fining scale and quantify the vulnerability of the Brazilian Northeast to climatic extremes, developing a methodology that combines aspects of vulnerability to drought, as well as socioeconomic and climatic indicators used to assess exposure, ability to adaptation and the sensitivity of geographical microregions of the region. The assessment of the susceptibility or degree of exposure to risk is the regional using the SPI (Standardized Precipitation Index) by the degree of magnitude dried (MD), the rate of precipitation such as PCD (Precipitation Concentration Degree) and PCP (Precipitation Period Concentration) helped characterize and regional climatology, these indices showed satisfactory results in the pilot study of Rio Grande do Norte to assess the degree of exposure to drought. Regarding sensitivity agricultural / livestock multivariate statistical technique to factor analysis showed acceptable results for the proposed model using data for the period 1990-1999 (P1). The application of the analysis of vulnerability considering the adaptive capacity, as the adaptive disability have almost similar results with much of the region's vulnerability to extreme south of Bahia state as a part of the semiarid region has a degree of vulnerability among moderate and mean

Material mnemonics and competing narratives in Palestine-Israel

Acknowledgements This work was supported by a grant from the Netherlands Institute for Advanced Study in the Humanities and Social Sciences (NIAS) and The Carnegie Trust for the Universities of Scotland [31860].