999 resultados para Transcription phonétique -- 19e siècle


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Contient : La Chalade ; copies (1175-1515) ; Châtillon ; extraits du cartulaire de l'abbaye (XIIe siècle) ; Chaumouzey (impr., in-4°, 1738) ; Clairlieu : mss. et impr., in-fol. (XIIe siècle-1738) ; Dieu-s'en-souvienne : inventaire de titres, extraits du cartulaire (1201-1705) ; Domêvre ; copies (1153-1705)

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This paper summarizes data on the factors involved in addiction and dependence to cigarettes. Nicotine has been intensively studied by the tobacco industry, for instance for its addictive effect at the lowest possible rates. The addition of diammonium phosphate and urea produces an alcalinization of the pH of cigarette smoke, and promotes the absorption and the trans-membrane passage of nicotine. The taste, the smell of smoke, and the visual aspect of the pack of cigarettes are also sensory components that promote addiction. Finally, menthol, sugar, cocoa and liquorice added to cigarettes also play a role in dependence and addiction to cigarettes by, for instance, making an anesthetic effect on the airways.

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We recently identified the winged-helix transcription factor Trident and described its expression pattern in synchronized fibroblasts. We have now studied Trident expression in cell lines, differentiating thymocytes and in lymphocytes derived from peripheral blood. During T cell differentiation, expression peaked in the actively dividing immature single positive cells. In peripheral blood lymphocytes, expression of Trident mRNA was absent, but could be induced upon stimulation with mitogens in vitro. These observations imply a function for Trident in dividing lymphocytes.