Liederkranz trip to Hundseck Portraits Groups

Liederkranzausflug nach Hundseck; Standing l-r; Sidi Ullmann, Ehepaar, Alfred und Toni Hirschland, Willi Ullmann, Lisel Suess, Lene Hesse-Sinzheimer, Julius Suess, ?, Hermann Boehm, Eugen Hirsch, Dr. Carl Kahn, Frau von Michael Rothschild (Ella?), Max Sinzheimer, Grete Hirschland and Alfred Liebmann ; Seated l-r: Adele Boehm, Michael Rothschild, rosel Suess, Louis Kahn (Junior), Ehepaar Dr. Gustav Hecht, Paula Hirsch and Marianne Kahn

Studio portrait of Liselotte "Lotte" Stern nee Wallerstein.

Photograph probably taken shortly before her marriage to Alfred Stern in 1928.

Studio portrait of Adolf Rothschild and Sophie Rothschild nee Cohn.

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Studio portrait of the six daughters of Solomon and Emilie Kohnberger: (l-r) Laura, Irene, Johanna, Melanie, Hermine and Martha.

Laura (1878-1917) died during a flu epidemic. She married Sigmund Stiassny and had two children, Lisbeth (Gersuny) (1900-1986) and Walter (1902-1912) who died of a ruptured appendix.

Schoenewald family portrait; Bad Nauheim, Germany.

Includes Rosi Schoenewald (sister of Dora), Dora Schoenewald (wife of Alfred Apfel and mother of Hannah Busoni), Henni Apfel, Tilly Schoenewald, Luise Schoenewald, Max Schoenewald (brother of Dora), Felix Schoenewald (brother of Dora), Samuel Schoenewald (brother of Dora), and Gerhardt Schoenewald

Studio portrait of Joseph and Meta Gruenstein Portraits Couples

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Studio portrait of Meti and Meta Gruenspecht Portraits Women

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Studio portrait of Max Gruenspecht and Regina Gruenspecht nee Epstein Portraits Couples

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Dieter, Herbert, Meta, Josef Gruenstein with Max Gruenspecht and Regina Gruenspecht née Epstein in front of the synagogue in Schwarza, Thuringia, Germany

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Studio portrait of seven of David Gruenspecht and Rebecca Gruenspecht nee Hoffman's ten children Portraits Family

Includes Louis Gruenspecht, Max Gruenspecht, Abraham (Adolf) Gruenspecht, Babette Gruenspecht, Isaac Gruenspecht, Moses (Moritz) Gruenspecht and Michael Gruenspecht; Missing are Rosalie Gruenspecht, Sarah Gruenspecht and Hirsch Gruenspecht

Studio portrait of David Gruenspecht and Rebecca Gruenspecht nee Hoffman with one of their young sons Portraits Family

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Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations

Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association scans from 14 studies totalling 28,141 participants of European descent, resulting in identification of 954 SNPs distributed across nine loci that exceeded the threshold of genome-wide significance, five of which are novel. Overall, the common variants associated with serum uric acid levels fall in the following nine regions: SLC2A9 (p = 5.2x10(-201)), ABCG2 (p = 3.1x10(-26)), SLC17A1 (p = 3.0x10(-14)), SLC22A11 (p = 6.7x10(-14)), SLC22A12 (p = 2.0x10(-9)), SLC16A9 (p = 1.1x10(-8)), GCKR (p = 1.4x10(-9)), LRRC16A (p = 8.5x10(-9)), and near PDZK1 (p = 2.7x10(-9)). Identified variants were analyzed for gender differences. We found that the minor allele for rs734553 in SLC2A9 has greater influence in lowering uric acid levels in women and the minor allele of rs2231142 in ABCG2 elevates uric acid levels more strongly in men compared to women. To further characterize the identified variants, we analyzed their association with a panel of metabolites. rs12356193 within SLC16A9 was associated with DL-carnitine (p = 4.0x10(-26)) and propionyl-L-carnitine (p = 5.0x10(-8)) concentrations, which in turn were associated with serum UA levels (p = 1.4x10(-57) and p = 8.1x10(-54), respectively), forming a triangle between SNP, metabolites, and UA levels. Taken together, these associations highlight additional pathways that are important in the regulation of serum uric acid levels and point toward novel potential targets for pharmacological intervention to prevent or treat hyperuricemia. In addition, these findings strongly support the hypothesis that transport proteins are key in regulating serum uric acid levels.

Freddy Godshaw (Gottschalk) with his friend Peter Zander celebrating their shared birthday; Cellerina, Switzerland.

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Studio portrait of Liselotte "Lotte" Stern nee Wallerstein.

Photograph probably taken shortly before her marriage to Alfred Stern in 1928.

Shimon Gottschalk with his wife Jo and family on his 70th birthday; Florida Portraits Family

Front row left to right: Tikkun, Back row: the twins, age 8, Shimon's wife Jo,, right: Ariela, age 28, the eldest